Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

阿尔茨海默病症状前认知能力下降的计算机化测试

基本信息

批准号：
10039211
负责人：
Peter Pebler
金额：
$ 20.23万
依托单位：
NEUROBEHAVIORAL SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10039211
关键词：
Administrative Supplement Affect Age Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease risk American Benchmarking California Clinic Clinical Trials Cognitive Computer Security Cooperative Research and Development Agreement Data Data Analyses Data Protection Data Security Databases Dementia Deterioration Enrollment Ensure Funding Generations Genetic Risk Goals Gold Health Insurance Portability and Accountability Act Healthcare Healthcare Systems Hospitals Hour Human Resources Impaired cognition Individual Infrastructure Institutional Review Boards Licensing Literature Longitudinal Studies Manuals Manuscripts Medical Medical center Memory Paper Participant Patient Recruitments Patients Peer Review Phase Play Population Procedures Property Protocols documentation Psychometrics Publications Research Research Design Research Personnel Resources Risk Role Scientist Secure Site Software Engineering Systems Integration Test Result Testing Training care burden cloud based cognitive testing computerized cost data hosting data management design field study inclusion criteria innovation interest meetings mental function novel therapeutics outreach recruit software development success symposium therapy design usability volunteer web site

项目摘要

Abstract. We are requesting an administrative supplement to expand participant recruitment and testing to the VA Northern California Healthcare System (VANCHCS) in Martinez. The supplement would reduce five potential risks to the long-term scientific impact of second generation California Cognitive Assessment Battery (CCAB-2) tests: • Recruitment. Participant recruitment has been compromised by the establishment of a California-funded Alzheimer’s Disease Research Center at our original recruitment site. Expanding recruitment and testing to the VANCHCS will resolve this problem and increase participant diversity: there are more than 32,000 eligible older participants within the VANCHCS catchment who meet study inclusion criteria. • Milestone completion. Our research plan calls for nearly 5,000 assessments over three years, with nearly 2,300 assessments planned in Phase II, year 1. This would require 9.1 assessments per day during year 1, i.e. approximately 20 hours of testing. The assistance of trained VA staff and the established VANCHCS’ infrastructure will assist us in meeting these testing challenges. • CCAB-2 compatibility with hospital data security protocols. In the original application, CCAB-2 testing was limited to NBS offices. The supplement will support the software development and testing needed to ensure that CCAB-2 tests function within secure healthcare IT networks with extensive data protection safeguards and HIPAA-compliant protocols. • CCAB-2 usability and robustness. In the original application, CCAB-2 test administration was limited to NBS personnel. This administrative supplement will enable extensive field testing by VA scientists and clinicians to ensure CCAB-2 robustness and usability prior to commercial launch. • Disseminating results. The extensive testing demands in the original application would limit NBS scientific outreach. The supplement will support VA scientists in publicizing CCAB-2 capabilities at conferences, Alzheimer’s Disease Centers, grand rounds, research labs, department colloquia, and in peer-reviewed publications.

摘要：我们正在请求行政补充以扩大参与者招募。并在马丁内斯的 VA 北加州医疗系统 (VANCCHS) 进行测试。补充将减少第二个项目的长期科学影响的五个潜在风险一代加州认知评估电池 (CCAB-2) 测试： • 参与者的招募因建立一个组织而受到影响。加州资助的阿尔茨海默病研究中心位于我们最初的招聘地点。将招募和测试范围扩大到 VANCHCS 将解决这个问题并增加参与者多样性：有超过 32,000 名符合资格的老年参与者 VANCHCS 学区符合研究纳入标准的人。 • 我们的研究计划要求在三年内进行近 5,000 项评估。年，计划在第二阶段第一年进行近 2,300 次评估。这将需要 9.1 第一年每天进行评估，即大约 20 小时的测试。训练有素的 VA 工作人员和已建立的 VANCHCS 基础设施将帮助我们满足这些要求测试挑战。 • CCAB-2 与医院数据安全协议的兼容性在原始应用中， CCAB-2 测试仅限于 NBS 办公室。该补充文件将支持该软件。确保 CCAB-2 测试在安全范围内运行所需的开发和测试具有广泛数据保护措施且符合 HIPAA 要求的医疗保健 IT 网络协议。 • CCAB-2 可用性和稳健性在原始应用程序中，CCAB-2 测试管理。该行政补充仅限于国家统计局人员。由 VA 科学家和忠诚者进行测试，以确保 CCAB-2 的稳健性和可用性商业启动。 • 原始应用中广泛的测试要求会限制传播结果。 NBS 科学推广将支持 VA 科学家宣传 CCAB-2。会议、阿尔茨海默病中心、大型查房、研究实验室、部门座谈会和同行评审出版物。