Rapid User Friendly POC Diagnostic for HSV

HSV 快速用户友好的 POC 诊断

基本信息

批准号：
10005820
负责人：
Raymond Preston Stowe
金额：
$ 18.96万
依托单位：
MICROGEN, LLC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-11 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10005820
关键词：
Antiviral Agents Archives Bedside Testings Biological Assay Buffers Clinical Clinical Pathology Collection Counseling Cytolysis Cytomegalovirus Cytomegalovirus Infections DNA Data Detection Development Diagnosis Diagnostic tests Disease Fetus Fluorescence Formulation Funding Genome Goals Gold Healthcare Systems Herpesvirus 1 Hospitals Human Human Herpesvirus 2 Human Resources Immunologics Infant Infection Infrastructure Label Laboratories Mediating Methods Morbidity - disease rate Neonatal Neonatology Neuraxis Nucleic Acid Amplification Tests Nucleic Acids Outcome Patients Performance Phase Process Reaction Reporter Reporting Reproducibility Research Research Design Risk Saliva Sampling Sensitivity and Specificity Simplexvirus Site Specimen Speed Spottings Standardization Surgical Flaps Survival Rate Swab Technology Testing Time Training United States National Institutes of Health Urine Vagina Validation Viral Virus Woman base biobank clinically relevant congenital cytomegalovirus cost design diagnosis standard field study fluorophore genital infection instrumentation internal control mortality neonatal patient neonate performance tests point of care point-of-care diagnostics prospective rapid diagnosis sample collection screening success transmission process user-friendly

项目摘要

Project Summary There is an urgent need for a point-of-care (POC) test to detect HSV that could be used to identify at-risk patients, in particular neonatal patients. A rapid, point-of-care (POC) test that could detect HSV infections would: (1) allow for immediate counseling and additional specimen collection for confirmatory testing, and (2) avoid having to create new laboratory infrastructure for widespread biospecimen testing. We propose develop a POC test for rapid screening of HSV in clinical specimens. This technology will also result in a significant cost reduction as compared to hospital and clinical pathology laboratory tests. The goal of this project is to develop an inexpensive and rapid (<30 min from specimen to result) screening assay for HSV infections.

项目概要迫切需要一种检测点护理 (POC) 检测来检测可用于识别高危患者的 HSV，特别是新生儿患者。可以检测 HSV 感染的快速护理点 (POC) 测试将：(1) 允许立即咨询和额外采集样本以进行验证性检测，以及 (2) 避免必须为广泛的生物样本测试创建新的实验室基础设施。我们建议开发一个 POC 测试快速筛查临床标本中的HSV。这项技术还将显着降低成本，因为与医院和临床病理实验室测试进行比较。该项目的目标是开发一种廉价的 HSV 感染的快速（从样本到结果不到 30 分钟）筛查测定。