The effect of switching on or off menthol use on cigarette consumption, dependence, nicotine exposure and quitting success

打开或关闭薄荷醇的使用对香烟消费、依赖性、尼古丁暴露和戒烟成功的影响

• 批准号: 10024540
• 负责人: Eric Leas
• 金额: $ 15.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10024540
• 关键词: Abstinence; Address; Adult; Age; Biochemical; Cigarette; Cigarette Smoker; Clinic; Confounding Factors (Epidemiology); Consumption; Data; Data Set; Dependence; Elderly; Ensure; Female; Goals; Health; Hispanics; Journals; Literature; Manuscripts; Measures; Menthol; Meta-Analysis; Modernization; Motivation; Nicotine Dependence; Not Hispanic or Latino; Policy Maker; Population; Probability; Procedures; Prospective Studies; Public Health; Race; Randomized; Recommendation; Regression Analysis; Sampling; Smoke; Smoker; Smoking; Smoking Behavior; Techniques; Testing; Tobacco Dependence; Tobacco use; Woman; Work; comparison group; control trial; design; follow-up; men; nicotine exposure; programs; randomized trial; secondary analysis; sex; smoking cessation; success; symposium; young adult

Projective Summary/Abstract While recommendations have been made to ban menthol from cigarettes, more robust evidence is needed on how such a ban would impact smoking behaviors. Moreover, while there is some evidence that menthol differentially impacts non-Hispanic Blacks’ and Hispanics’ smoking behavior, little evidence exists comparing the impact of menthol among females and young adults (18-24 years), who also smoke menthol at higher rates than their counterparts. Data from the longitudinal Population Assessment of Tobacco Use and Health (PATH) Study addresses many limitations presented in the current literature on menthol use and smoking behaviors. The PATH Study’s multi-wave design is nationally representative of the US and provides: 1) high- quality measures of smoking cessation, cigarette consumption, biochemical exposure to nicotine, and tobacco dependence; 2) over-sampling of non-Hispanic Blacks and young adults (18-24 years) to provide representative estimates across these subpopulations; and 3) repeated assessment of switching on and off menthol that, in many ways, mirrors how a randomized control trial would assess the impact of a smoking ban. In addition, because we expect that the non-random assignment of switching on or off menthol could be incited by a variety of factors (e.g., motivation to quit) that also effect cessation and consumption, we will use a modern analytical technique known as propensity score matching (PSM) to address this confounding bias. Using PSM and the adult sample of cigarette smokers in Waves 1-4 in the PATH Study, the proposed study will complete the following aims: Aim 1: Compare quitting success between quit attempters who had switched on or off menthol cigarettes. Aim 2: Compare consumption, nicotine exposure, and dependence between adult smokers who switch on or off menthol cigarettes without successfully quitting. Aim 3: Assess whether race, sex or age modify the effect of switching on or off menthol cigarettes on 30-day cigarettes abstinence, 12-month cigarette abstinence, consumption, dependence, and nicotine exposure. These aims align with the goals of RFA-OD-19-022 by using an existing dataset to address a regulatory question regarding the potential impact of menthol on adult tobacco use and nicotine exposure. We anticipate that the work will result in four conference presentations and three manuscripts aimed at journals read by public health policy makers.

投影摘要/摘要 虽然已经提出了禁止薄荷醇中的香烟的建议，但更有力的证据 这种禁令需要如何影响吸烟行为。 大量影响非西班牙裔黑人和西班牙裔吸烟的证据 行为，几乎没有证据比较薄荷醇在女性和年轻人中的影响 成年人（18-24岁），他们也比同行的薄荷醇吸烟。 烟草使用与健康（PATH）研究的纵向人口评估 目前的文献中存在许多限制 Path研究的多波浪设计在全国范围内对美国的压抑，并提供：1）高 - 戒烟，征兵，生化态度的质量度量 尼古丁和烟草依赖性； 2）非西班牙裔黑人和年轻人 （18-24年）在整个子范围内提供代表性的估计； 评估打开和关闭薄荷醇的评估，这些评估在许多方面都反映了随机的方式 控制试验还将评估禁令的影响。 非随机打开或关闭薄荷酚的非随机分配可能会因多种因素而引起 （例如，退出的动机）也会影响停止和消费，我们将使用现代 分析技术称为倾向得分匹配（PSM），以解决这种混杂 偏见。 支撑研究将完成以下目的：目标1：比较退出成功 戒烟的人已经打开或关闭了薄荷烟。 尼古丁的暴露以及开启或关闭薄荷醇的成年吸烟者之间的依赖性 成功退出的香烟。 在30天的戒酒中打开或关闭薄荷香烟的影响，12个月 戒烟，消费，依赖和尼古丁的暴露。 RFA-OD-19-022的目标通过使用现有数据集解决 关于薄荷醇对成人烟草使用和尼古丁暴露的潜在影响 预期Wilk的工作将导致四个会议演讲和三个针对的手稿 在公共卫生政策制定者阅读的期刊上。