UTMB OAIC Biostatistics and Data Management Resource Core 3 (BDMRC3)

UTMB OAIC 生物统计和数据管理资源核心 3 (BDMRC3)

• 批准号: 10027669
• 负责人: Yong-Fang Kuo
• 金额: $ 16.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10027669
• 关键词: Abbreviations; Address; Aging; Algorithms; American; Analysis of Variance; Applications Grants; Biology; Biometry; Biostatistical Methods; Capsicum; Clinical; Clinical Research; Clinical Trials; Collaborations; Community Health; Comparative Effectiveness Research; Data; Data Analyses; Data Management Resources; Data Sources; Databases; Development; Elderly; Electronic Health Record; Faculty; Funding; Goals; Grant; Heterogeneity; Hispanics; Human Resources; Individual; Informatics; Information Systems; Infrastructure; Institutes; Intervention; Intervention Studies; Investigation; Joints; K-Series Research Career Programs; Leadership; Link; Longitudinal Studies; Measurement; Mentors; Metabolism; Methodology; Minority; Modeling; Monitor; Observational Study; Outcome; Pathway Analysis; Pathway interactions; Patient-Focused Outcomes; Physical Function; Pilot Projects; Play; Population; Pragmatic clinical trial; Preparation; Preventive Medicine; Process; Publications; Recovery; Recovery of Function; Research; Research Design; Research Methodology; Research Personnel; Research Training; Resource Sharing; Resources; Risk; Role; Sample Size; Sequential Multiple Assignment Randomized Trial; Source; Specimen; Statistical Data Interpretation; Statistical Methods; Systems Analysis; Texas; Training; Translating; Translational Research; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Visual; analytical method; biobank; cohesion; computer science; computerized data processing; data infrastructure; data management; design; education research; epidemiology study; experience; experimental study; faculty mentor; follow-up; functional gain; functional loss; functional outcomes; improved; innovation; loss of function; member; muscle hypertrophy; next generation sequencing; novel; patient subsets; power analysis; recruit; research and development; stem; stroke patient; tool; trial design

PROJECT SUMMARY/ABSTRACT (BDMRC3) The UTMB OAIC Biostatistics and Data Management Resource Core 3 (BDMRC3) provides biostatistical support, collaboration and training, and develops novel biostatistic and data management tools for research relevant to the UTMB OAIC theme which is Translate pathways of functional loss and gain into interventions to optimize functional recovery in diverse geriatric populations. Since its establishment as a new OAIC Resource Core in 2014, the BDMRC3 has rapidly developed strong working relationships with OAIC investigators, and supported six Scholars, 17 OAIC pilot/developmental projects, six NIH R and K grants, three T32, one F30, two large AHRQ grants, and a Texas CPRIT center grant. It has produced 54 publications. Specific aims of the BDMRC3 are: 1. Collaborate as investigators for OAIC projects with focus on improving physical function and recovery in older adults. The projects include pilot studies, developmental projects, and externally funded research; 2. Train Research Education Core (REC) scholars in biostatistics and data management to help them plan, conduct, and interpret results of their investigations in aging; 3. Enhance research information system infrastructure to assist in the procurement, management, and processing of data collected from extant databases; 4. Develop novel biostatistics methods and visual analytic applications for aging research. The significance of BCMRC3 for the UTMB OAIC is related to four main tasks. 1) Expanding the data infrastructure to consolidate and harmonize measurements across OAIC projects and data sources, enhance accessibility in the use of EHR data for multiple OAIC projects, and share available sources of data with the UTMB RCMAR and UTMB P2C; 2) BCMRC3 personnel collectively operates as a key resource for design, analysis, and interpretation in OAIC projects; 3) BCMRC3 faculty mentors REC scholars, leading to long-term collaborations and more effective research development; and 4) BCMRC3 members develop and adapt novel analytical methods to improve the validity and utility of results stemming from OAIC research.

项目摘要/摘要 (BDMRC3) UTMB OAIC 生物统计和数据管理资源核心 3 (BDMRC3) 提供生物统计 支持、协作和培训，并开发新颖的生物统计和数据管理工具用于研究 与 UTMB OAIC 主题相关，即将功能丧失和增益的途径转化为干预措施 优化不同老年人群的功能恢复。自作为新的 OAIC 资源成立以来 以 2014 年为核心，BDMRC3 迅速与 OAIC 调查人员建立了牢固的工作关系，并且 支持六名学者、17 个 OAIC 试点/开发项目、六项 NIH R 和 K 拨款、三项 T32、一项 F30、两项 大量 AHRQ 拨款和德克萨斯州 CPRIT 中心拨款。它已出版了 54 种出版物。 BDMRC3 的具体目标是： 1. 作为 OAIC 项目的研究者进行合作，重点关注改善身体功能和康复 老年人。这些项目包括试点研究、开发项目和外部资助的研究； 2. 培训生物统计学和数据管理领域的研究教育核心（REC）学者，为他们提供帮助 计划、进行和解释老龄化研究的结果； 3. 加强科研信息系统基础设施，协助采购、管理和研究 处理从现有数据库收集的数据； 4. 开发用于衰老研究的新型生物统计学方法和视觉分析应用。 BCMRC3 对于 UTMB OAIC 的意义与四项主要任务有关。 1）扩展数据 整合和协调跨 OAIC 项目和数据源的测量的基础设施，增强 多个 OAIC 项目使用 EHR 数据的可访问性，并与 UTMB RCMAR 和 UTMB P2C； 2) BCMRC3 人员作为设计的关键资源共同运作， OAIC 项目的分析和解释； 3) BCMRC3 教师指导 REC 学者，带来长期的 合作和更有效的研究开发； 4) BCMRC3 成员开发和改编小说 提高 OAIC 研究结果的有效性和实用性的分析方法。