West Virginia University Stroke COBRE

西弗吉尼亚大学中风 COBRE

• 批准号: 10025931
• 负责人: Elizabeth Engler-Chiurazzi
• 金额: $ 24.13万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10025931
• 关键词: Advisory Committees; Applications Grants; Area; Automation; Award; Behavior; Behavior assessment; Behavioral; Behavioral Assay; Biomedical Research; Brain; Brain Diseases; Centers of Research Excellence; Charge; Communities; Computer software; Consultations; Core Facility; Data; Data Collection; Educational workshop; Equipment; Evaluation; Experimental Designs; Faculty; Fees; Funding; Growth; Human; Instruction; Investments; Measures; Medical; Methods; Mission; Persons; Phase; Pre-Clinical Model; Procedures; Publications; Publishing; Quality Control; Quality of life; Recommendation; Reproducibility; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Role; Schedule; Services; Shoulder; Statistical Data Interpretation; Stroke; Testing; Therapeutic Intervention; Training; Universities; Wages; West Virginia; Work; Writing; behavior test; comorbidity; cost; design; faculty support; functional outcomes; improved; instrumentation; journal article; nervous system disorder; novel therapeutic intervention; operation; post stroke; programs; recruit; stroke therapy; testing services; tool; university student

PROJECT SUMMARY Neurological disorders including stroke are highly prevalent and have substantial medical, financial, and human costs, including behavioral/functional disruptions that negatively impact quality of life. As such, the inclusion of functional assessments in studies of brain disorders is a necessary component of a high-profile, translational, and impactful biomedical research program. In this way, the West Virginia University (WVU) Rodent Behavior Core (RBC), a shared instrumentation facility dedicated to the assessment of functional outcomes in rodents, is a vital component of the WVU Stroke Center for Biomedical Research Excellence (WVU Stroke CoBRE). WVU RBC staff offer comprehensive behavioral testing services from ‘design to dissemination’ that include: consultation on experimental design and task selection, writing assistance, behavior testing training, conducting behavioral tests, maintaining RBC equipment, hardware and software, and data entry and statistical analysis assistance. To date, the RBC offers 27 distinct stroke-relevant tests comprising 5 domains of brain function that have enabled the facility and staff to support the work of 64 WVU investigators and trainees. This support has resulted in the submission of 58 internal and external grant proposals in which behavioral assays were proposed (18 of which have been funded). As well, 26 journal articles that utilized RBC services have been published. For Phase II of the WVU Stroke CoBRE, the RBC will 1) continue to provide high quality resources and operational support to the WVU Stroke CoBRE Junior Investigators, 2) implement new capabilities, facilities, and operation procedures to a productive core to support behavioral assessments, and 3) progress the RBC towards fiscal independence from the WVU Stroke CoBRE. Capitalizing on the successful implementation of the WVU RBC during the initial period, achieving these specific aims will enhance our ability to provide all necessary equipment, resources, and expertise to conduct rodent behavioral assessments to support WVU Stroke CoBRE-funded projects as well as other WVU investigators. This will enable the RBC to become a premiere facility for the assessment of rodent behavior, poise WVU to emerge as a center for excellence in the evaluation of stroke and its comorbidities, and support translational and collaborative research to enhance our understanding of neurological disorders and elucidating possible therapeutic interventions for the treatment of stroke and other brain disease.

项目摘要 包括中风在内的神经系统疾病非常普遍，并且具有大量的医学，财务和人类 成本，包括对生活质量产生负面影响的行为/功能中断。因此，包括 脑疾病研究中的功能评估是备受瞩目的，翻译的必要组成部分 和有影响力的生物医学研究计划。这样，西弗吉尼亚大学（WVU）啮齿动物行为 Core（RBC）是一种致力于评估啮齿动物功能结果的共享仪器设施，是 WVU中风生物医学研究中心卓越中心（WVU Stroke Cobre）的重要组成部分。 WVU RBC的工作人员提供全面的行为测试服务，包括： 有关实验设计和任务选择，写作帮助，行为测试，进行进行的咨询 行为测试，维护RBC设备，硬件和软件以及数据输入和统计分析 协助。迄今 使设施和工作人员能够支持64名WVU调查人员和受训人员的工作。这个支持有 提出了提出行为分析的58项内部和外部赠款提案的提交 （其中18个已资助）。同样，已经发表了26篇使用RBC服务的期刊文章。为了 WVU中风毛绒的第二阶段，加拿大皇家银行将1）继续提供高质量的资源和运营 支持WVU中风柯布尔初级调查员，2）实施新的功能，设施和操作 为了支持行为评估的生产力核心的程序，3）将RBC迈向财政 独立于WVU中风的鞋垫。利用成功实施WVU RBC 在最初的时期，实现这些特定目标将增强我们提供所有必要设备的能力， 资源和专业知识，以进行啮齿动物行为评估以支持WVU中风鞋带资助 项目以及其他WVU调查人员。这将使加拿大皇家银行成为首映式 评估啮齿动物行为，使WVU成为中风评估的卓越中心 它的合并症，并支持翻译和协作研究，以增强我们对 神经系统疾病，并阐明了中风和其他治疗的可能治疗干预措施 脑部疾病。