SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION - AIM 3

复极和早期复极的性别差异 - 目标 3

• 批准号: 7604306
• 负责人: Alan H Kadish
• 金额: $ 5.44万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604306
• 关键词: SEX; DIFFERENCES; REPOLARIZATION; EARLY; AIM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we hypothesize that the level of sex hormones is a major determinant of myocardial repolarization (ST height). The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population of subjects (young and old men and women) without heart disease undergoing hormonal replacement therapy and in subjects not undergoing hormal replacement therapy. Specifically, subjects will be given an echocardiogram (a test using a sound wave that outlines the size of the heart and determines how well the heart is functioning), asked to do an exercise test on a stationary bicycle (which records the heart's electrical activity while the subject is pedaling), undergo, if females with regular menstrual cycles, a urinary ovulation predictor test and give 20ccs of blood to determine several sex hormone levels. We will seek to determine the magnitude of changes in ST variables according to hormone levels changes occuring during the different phases of a normal menstrual cycle and following a long-term sex hormones therapy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在这个项目中，我们假设性激素水平是心肌复极（ST 高度）的主要决定因素。 支持这项研究的基本原理是，对某些心律失常（心跳不规则）的易感性存在重要的性别差异，表明男性和女性之间存在基本的电生理差异。 为了检验我们的假设，我们将在接受激素替代治疗的无心脏病受试者和未接受激素替代治疗的受试者混合人群（年轻和老年男性和女性）中检查 ST 高度与性激素水平之间的关系。 具体来说，受试者将接受超声心动图（使用声波进行的测试，概述心脏的大小并确定心脏的功能情况），并要求受试者在固定自行车上进行运动测试（记录心脏的电活动，同时记录心脏的电活动）。如果是月经周期规律的女性，则进行尿排卵预测测试，并抽取 20cc 血液以确定几种性激素水平。 我们将根据正常月经周期不同阶段以及长期性激素治疗后发生的激素水平变化，寻求确定 ST 变量变化的幅度。