Core A: Administration

核心A：管理

• 批准号: 10005186
• 负责人: ROBERT H VONDERHEIDE
• 金额: $ 6.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005186
• 关键词: Abramson Cancer Center at the University of Pennsylvania; Achievement; Cancer Center; Communication; Discipline; Ensure; Environment; Equilibrium; Faculty; Fostering; Foundations; Goals; Government; Immunity; Immunotherapy; Knowledge; Leadership; Malignant Neoplasms; Mus; Nature; Patients; Policies; Radiation; Regulation; Reporting; Research; Research Personnel; Role; Services; Structure; T-Lymphocyte; cancer immunotherapy; design; immune checkpoint blockade; meetings; programs; synergism; tumor

SUMMARY The Administrative Core A of this Program Project is designed to provide scientific leadership, effective communication and an administrative support structure to ensure the coordination of all Program Project activities. In 2015, the four PIs of this multiple PI P01 proposal reported in Nature that hypofractionated radiation and dual checkpoint blockade activated anti-tumor T cell immunity in both mice and patients via non-redundant mechanisms, explaining the apparent synergy. This newly proposed Program Project seeks to deeply extend our knowledge regarding the intersection of radiation and immunotherapy of cancer. The proposed program has three projects and three cores, with a balance of senior leaders in multiple disciplines working alongside more junior faculty investigators as a team. We have taken advantage of the large and efficient administrative staff and the centralized research organizations at the Abramson Cancer Center (ACC) of the University of Pennsylvania to achieve our objectives. Strong institutional commitment from the ACC and Penn has helped lay the foundation for our scientific and translational achievements. The essential services provided by the Core A include: administrative support for all of the investigators in each project and core; fiscal management and oversight for all components of the Program Project; and organization and communication of all Program Project meetings and activities. The overall goal of this Core is effective and efficient leadership of the P01. The roles of the Core Director, Co-Director and administrative staff are to facilitate communication while stimulating scientific and technological interactions. In order to achieve this goal, the Core has established three objectives: (1) Establish and maintain an administrative structure to provide support for and management of all Program Project activities, (2) Foster an environment to maximize collaborative research among Program Project investigators and between other P01 and NCI initiatives, and (3) Ensure compliance with all institutional, governmental and NCI regulations and policies.

概括 该计划项目的行政核心A旨在提供科学领导，有效 沟通和行政支持结构，以确保所有计划的协调 项目活动。在2015年，此多个PI P01提案的四个PI在本质上报道了 两者中的降压辐射和双重检查点阻滞激活的抗肿瘤T细胞免疫力 小鼠和患者通过非冗余机制解释了明显的协同作用。这个新 拟议的计划项目旨在深入扩展我们有关辐射交集的知识 和癌症的免疫疗法。拟议的计划有三个项目和三个核心， 与更多初级教师调查员一起工作的多个学科中的高级领导者的平衡 团队。我们已经利用了庞大而有效的行政人员和集中的 宾夕法尼亚大学艾布拉姆森癌症中心（ACC）的研究组织 实现我们的目标。 ACC和Penn的强大机构承诺帮助了 我们的科学和翻译成就的基础。由 核心A包括：为每个项目和核心中所有调查人员的行政支持；财 该计划项目的所有组件的管理和监督；和组织和 所有计划项目会议和活动的沟通。该核心的总体目标是有效的 和P01的有效领导。核心主任，联合主任和行政人员的角色 在刺激科学和技术互动的同时促进沟通。为了 实现这一目标，核心已经建立了三个目标：（1）建立和维护一个 为所有计划项目活动提供支持和管理的行政结构，（2） 促进环境，以最大化计划项目调查人员和 在其他P01和NCI计划之间，以及（3）确保遵守所有机构，政府 和NCI法规和政策。