Boosting mind-body mechanisms for mitigating neuroinflammation in migraine

增强身心机制以减轻偏头痛的神经炎症

基本信息

批准号：
10000038
负责人：
Marco Luciano Loggia
金额：
$ 67.79万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10000038
关键词：
Aftercare Animals Anti-Inflammatory Agents Astrocytes Attitude Awareness Brain Brain Stem Cell Nucleus Clinical Coupled Coupling Data Data Set Disease Education Fiber Frequencies Functional Magnetic Resonance Imaging Functional disorder Generations Healthcare Systems Institute of Medicine (U.S.)Insula of Reil Intervention Intervention Studies Ligand Binding Link Magnetic Resonance Measurable Measures Mediating Mediation Medical Methods Microglia Migraine Mind Mind-Body Intervention Molecular Neurobiology Outcome Pain Patients Planets Positron-Emission Tomography Proteins Reporting Role Scanning Severities Signal Transduction Spreading Cortical Depression Testing Thalamic structure Therapeutic Transcutaneous Electric Nerve Stimulation active method afferent nerve arm body-mind chronic pain chronic pain patient chronic painful condition design experience glial activation improved mindfulness mindfulness meditation mindfulness-based stress reduction multimodality neuroinflammation noradrenergic protein biomarkers radioligand recruit relating to nervous system respiratory symptomatology synergism therapeutic target vagus nerve stimulation

项目摘要

Project Summary/Abstract Migraine headaches represent the third most prevalent medical disorder on the planet, yet many sufferers are not satisfactorily treated, and 3% of them suffer chronification of their migraine every year. Cortical spreading depression and hyperexcitability of the brain have been demonstrated in migraine, and migraine pain has been related to neuroinflammation. In this project, we propose to use PET/MRI using a translocator protein marker (TSPO), as well as a measure of the infra-slow oscillatory activity to assess neuroinflammation in migraine. Then, we will examine the effect of a mind-body therapy on neuroinflammation. Our design will combine a top- down approach, namely mindfulness mediation, with a bottom-up approach, i.e. non-invasive transcutaneous vagus nerve stimulation, and examine the synergistic effect of these therapies on both microglial/astrocytic activation as measured with PET and on the fluctuation of low-frequency oscillatory activity. Our results will indicate whether a coupling of a top-down with a bottom-up therapeutic approach can have measurable effects on neuroinflammation in migraine, and indicate whether glial activation may be a therapeutic target for migraine.

项目概要/摘要偏头痛是地球上第三大最常见的疾病，但许多患者治疗效果不佳，每年有 3% 的人患有慢性偏头痛。皮质扩散偏头痛已被证实与大脑抑郁和过度兴奋有关，并且偏头痛已被证实与神经炎症有关。在这个项目中，我们建议使用 PET/MRI 和易位蛋白标记物（TSPO），以及用于评估偏头痛神经炎症的亚慢振荡活动的测量。然后，我们将检查身心疗法对神经炎症的影响。我们的设计将结合顶部向下的方法，即正念冥想，自下而上的方法，即非侵入性经皮迷走神经刺激，并检查这些疗法对小胶质细胞/星形细胞的协同作用 PET 测量的激活以及低频振荡活动的波动。我们的结果将表明自上而下与自下而上治疗方法的结合是否可以产生可测量的效果偏头痛的神经炎症，并表明神经胶质激活是否可能是偏头痛的治疗靶点偏头痛。