THROMBOPHILIA IN CRYPTOGENIC STROKE (THICK) STUDY

隐源性中风（厚重）研究中的血栓形成倾向

• 批准号: 7604171
• 负责人: JORGE R KIZER
• 金额: $ 1.36万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604171
• 关键词: Blood Platelets; CD39 antigen; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Patent Foramen Ovale; Pathogenesis; Platelet Activation; Research; Research Personnel; Resources; Risk Factors; Role; Source; Stroke; Thrombophilia; United States National Institutes of Health; Venous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this study are to: (1) determine whether venous thrombophilias are independent risk factors for cryptogenic stroke; (2) examine whether venous thrombophilias are a risk factor for cryptogenic stroke in the presence of patent foramen ovale; (3) evaluate the independent role of arterial thrombophilias in the pathogenesis of cryptogenic stroke; and (4) assess the role of CD39/NTPDase-1 and platelet reactivity in the pathogenesis of cryptogenic strkoe. The investigators hypothesize that venous thrombophilias are risk factors only in the presence of a patent foramen ovale, whereas arterial thrombophilias are risk factors independent of a patent foramen ovale. Similarly, the investigators hypothesize that reduced NTPDase-1 activity and increased platelet activation are risk factors for cryptogenic stroke in the absence of patent foramen ovale.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是：（1）确定静脉血栓形成倾向是否是隐源性卒中的独立危险因素； (2) 检查静脉血栓形成倾向是否是存在卵圆孔未闭的情况下隐源性卒中的危险因素； (3)评估动脉血栓形成倾向在隐源性卒中发病机制中的独立作用； (4)评估CD39/NTPDase-1和血小板反应性在隐源性strkoe发病机制中的作用。 研究人员假设，静脉血栓形成倾向仅在卵圆孔未闭的情况下才是危险因素，而动脉血栓形成倾向是独立于卵圆孔未闭的危险因素。同样，研究人员推测，在没有卵圆孔未闭的情况下，NTPDase-1 活性降低和血小板活化增加是隐源性中风的危险因素。