Wake Forest NCORP Research Base

维克森林大学NCORP研究基地

• 批准号: 10021225
• 负责人: GLENN J LESSER
• 金额: $ 92.41万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10021225
• 关键词: Address; Age; Aging; Area; Behavioral Sciences; Biological; Biometry; Blood; Cancer Control; Cardiology; Cardiovascular system; Caregivers; Caring; Clinical Research; Collaborations; Collection; Communities; Community Clinical Oncology Program; Comprehensive Cancer Center; Country; Data; Development; Early treatment; Enrollment; Faculty; Family; Funding; Future; Goals; Health Sciences; Health Services Research; Image; Individual; Infrastructure; Interdisciplinary Study; Intervention; Investigation; Late Effects; Liquid substance; Malignant Neoplasms; Mentors; NCI Center for Cancer Research; NCI-Designated Cancer Center; Neurocognitive; Neurosciences; Outcome; Participant; Patients; Personal Satisfaction; Postdoctoral Fellow; Prevention; Primary Health Care; Process; Protocols documentation; Public Health; Radiation; Radiation therapy; Research; Research Activity; Research Design; Research Personnel; Resources; Salivary; Sampling; Science; Site; Specimen; Students; Supportive care; Symptoms; Time; Toxic effect; Training; Treatment Efficacy; Treatment outcome; Underserved Population; Urine; Woman; base; biobank; cancer care; cancer complication; cancer health disparity; cancer site; cancer therapy; care delivery; care systems; chemotherapy; clinical investigation; early-career faculty; ethnic minority population; evidence base; forest; health disparity; improved; innovation; knowledge translation; medical schools; multidisciplinary; next generation; novel; oncology; patient oriented; patient population; protocol development; racial and ethnic; racial minority; recruit; research study; rural dwellers; survivorship; underserved minority

The overarching goal of the Wake Forest NCORP Cancer Center Research Base (WF NCORP RB) is to improve patient well-being and the quality of cancer care by developing, implementing and successfully completing innovative and feasible Cancer Control and Cancer Care Delivery (CCDR) clinical research studies. For nearly two decades as a CCOP and now NCORP Research Base, Wake Forest has maintained an exclusive focus on Cancer Control and CCDR studies and has emphasized efficient operational processes and extensive interactions with our NCORP Community Site and Minority Underserved Community Site partners. During the first 4 years of the NCORP network, the WF NCORP RB: opened 7 Cancer Control and 3 CCDR studies; enrolled 1,140 participants on WF NCORP RB studies; obtained approval for 5 additional concepts and protocols bringing the total remaining and planned accrual for active and pending trials to over 4,420 participants; and achieved a 33% accrual rate of racial/ethnic minority participants, as well as 68% women, 14% rural residents and 26% age 65 or greater. Over the next 6 years, we will build on and strengthen this highly successful platform by accomplishing the following Specific Aims: Specific Aim 1: Extend our cancer control clinical research activities in the following areas: cardiovascular complications of cancer therapy; radiation and chemotherapy-induced neurocognitive toxicities; and additional cancer and treatment-related symptoms and related-outcomes prioritized by NCI steering committees and those commonly associated with novel emerging treatment paradigms. Specific Aim 2: Elucidate and intervene upon patient, family, clinician, and organizational factors that influence cancer care delivery, emphasizing survivorship care, informal cancer caregivers and implementation of evidence-based supportive care services. Specific Aim 3: Illuminate biological mechanisms underlying cancer and treatment-related symptoms and toxicities in new and innovative multidisciplinary collaborative studies taking advantage of our growing biobank of blood, urine and salivary fluid specimens. Specific Aim 4: Identify and address determinants of cancer disparities via disparities-focused studies, integrated aims focused on underserved populations, and targeted recruitment of racial and ethnic minority and underserved populations across all Wake Forest NCORP research investigations. Specific Aim 5: Train the next generation of Cancer Control and CCDR researchers through mentoring and involvement of early career faculty, oncology trainees, post-doctoral fellows, and students in WF NCORP activities. Our ongoing and proposed Cancer Control and CCDR studies will continue to improve oncology care by informing best practices for symptom and late effect management as well as efficient, patient-centered, evidence-based cancer care delivery for diverse patient populations. In the next funding period, the WF NCORP RB will help accelerate the translation of knowledge in cancer control and cancer care delivery through close partnership with community and minority underserved sites and studies designed for future dissemination and implementation.

Wake Forest Ncorp癌症中心研究基地（WF NCORP RB）的总体目标是改善 通过开发，实施和成功完成的患者福祉和癌症护理的质量 创新且可行的癌症控制和癌症护理递送（CCDR）临床研究。差不多 维克森林（Wake Forest 癌症控制和CCDR研究，并强调有效的操作过程和广泛 与我们的NCORP社区站点和少数民族服务不足的社区现场合作伙伴的互动。在 NCORP网络的前4年，WF NCORP RB：开放了7个癌症控制和3个CCDR研究；注册 WF NCORP RB研究的1,140名参与者；获得了5个其他概念和协议的批准 对4,420多名参与者进行主动和未决试验的剩余和计划应计；并取得了成就 33％的种族/少数民族参与者的应计率，以及68％的妇女，14％的农村居民和26％的年龄 65或更高。在接下来的六年中，我们将建立并加强这个非常成功的平台 完成以下特定目标：特定目标1：扩展我们的癌症控制临床研究活动 在以下领域：癌症治疗的心血管并发症；放射线和化学疗法引起的 神经认知毒性；以及其他癌症和治疗相关的症状和相关症状 由NCI指导委员会和通常与新兴治疗相关的委员会优先考虑 范式。特定目的2：阐明和干预患者，家庭，临床医生和组织因素 这会影响癌症护理的分娩，强调生存护理，非正式癌症护理人员和 实施基于证据的支持护理服务。特定目的3：照亮生物学机制 新的和创新的多学科的潜在癌症和治疗相关症状和毒性 协作研究利用了我们不断增长的血液，尿液和唾液液标本的生物库。 特定目的4：通过以差异为中心的研究确定和解决癌症差异的决定因素， 综合目的集中于服务不足的人群，并有针对性地招募种族和少数民族的招募 在所有Wake Forest NCORP研究调查中，服务欠佳的人群。特定目标5：训练 下一代癌症控制和CCDR研究人员通过指导和参与早期职业 教师，肿瘤学学员，博士后研究员和WF NCORP活动的学生。我们正在进行的和 拟议的癌症控制和CCDR研究将继续通过告知最佳实践来改善肿瘤学护理 用于症状和晚期效应管理以及高效，以患者为中心的循证癌症护理 分娩的患者人群。在下一个资金期间，WF NCORP RB将有助于加速 通过与社区的密切合作伙伴关系来翻译癌症控制和癌症护理交付的知识 以及为未来传播和实施而设计的少数民族站点和研究。