Admin-Core-001

管理核心-001

基本信息

批准号：
10025683
负责人：
PETER Karl SORGER
金额：
$ 21.19万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-08 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10025683
关键词：
Achievement Administrative Coordination Administrator Advisory Committees Alzheimer&apos s disease related dementia Area Belief Biocompatible Materials Bioinformatics Cancer Biology Cardiology Clinical Sciences Collaborations Communication Communication Tools Complement Computational Biology Computational Science Congresses Data Deposition Development Drug resistance Ensure Evaluation Evolution Experimental Designs Faculty Feedback Funding Future Goals Grant Hospitals Immune checkpoint inhibitor Infrastructure Knowledge Laboratories Lead Leadership Link Malignant Neoplasms Malignant neoplasm of brain Measurement Methodology Methods Modeling Monitor Nature Pharmaceutical Preparations Pharmacology Pilot Projects Postdoctoral Fellow Process Progress Reports Reagent Research Research Activity Research Personnel Research Project Grants Research Training Resistance Risk Role Scientist Site Statistical Computing Statistical Models Structure Students Support System System Systems Biology Toxic effect Training United States National Institutes of Health Update Ursidae Family Validation Visit Work base computer science drug sensitivity experience experimental study innovation inter-institutional malignant breast neoplasm meetings melanoma multidisciplinary operation organizational structure outreach response senior faculty skills small molecule symposium treatment response web site website development

项目摘要

The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center’s scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.

行政核心由教职员工团队组成，他们将共同监督研究，该中心的培训、规划和外展活动具有多学科、跨机构的性质。该提案不仅重视有效的科学管理，而且还创造了许多机会该组织的结构极大地促进了与其他组织的合作。 HMS 系统药理学实验室 (LSP)，当前提案的基础。成立于 2014 年，旨在精确支持此处提出的系统生物学研究类型，并进行了拆分实验室和计算研究之间约 60:40。我们的管理计划反映了这样的信念：系统生物学方法的有效应用了解黑色素瘤、脑癌和乳腺癌药物敏感性和耐药性的预测因素需要具有跨计算生物学、临床等多种技能的研究人员的参与科学、生物信息学、系统生物学和统计推理将支持。该团队的努力，帮助学生、博士后和初级教师成为系统未来的领导者癌症生物学（目标 1.1）。核心将促进参与实验的不同小组举行会议。设计（目标 4 项目 1；目标 5 项目 2；目标 6 项目 3）以及测量和分析方法由系统药理学核心执行（目标 2）。它还将组织一个外部咨询委员会。（目标 1.2），协调中心试点拨款（目标 1.2）并开发一个网站以共享有关中心的活动（目标 1.1）并分发其结果和数据。行政核心将监督中心的活动。中心的整体科学进展，并使用一般和评价中心的科学成果最后，核心还将支持中心的外展工作。活动包括网站开发、培训以及未来与访问科学家的合作（目标 1.1）。本文描述的计划将确保研究人员之间的有效沟通和互动中心并与 NCI 和其他系统生物学中心合作。