Admin-Core-001

管理核心-001

基本信息

批准号：
10025683
负责人：
PETER Karl SORGER
金额：
$ 21.19万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-08 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10025683
关键词：
Achievement Administrative Coordination Administrator Advisory Committees Alzheimer&apos s disease related dementia Area Belief Biocompatible Materials Bioinformatics Cancer Biology Cardiology Clinical Sciences Collaborations Communication Communication Tools Complement Computational Biology Computational Science Congresses Data Deposition Development Drug resistance Ensure Evaluation Evolution Experimental Designs Faculty Feedback Funding Future Goals Grant Hospitals Immune checkpoint inhibitor Infrastructure Knowledge Laboratories Lead Leadership Link Malignant Neoplasms Malignant neoplasm of brain Measurement Methodology Methods Modeling Monitor Nature Pharmaceutical Preparations Pharmacology Pilot Projects Postdoctoral Fellow Process Progress Reports Reagent Research Research Activity Research Personnel Research Project Grants Research Training Resistance Risk Role Scientist Site Statistical Computing Statistical Models Structure Students Support System System Systems Biology Toxic effect Training United States National Institutes of Health Update Ursidae Family Validation Visit Work base computer science drug sensitivity experience experimental study innovation inter-institutional malignant breast neoplasm meetings melanoma multidisciplinary operation organizational structure outreach response senior faculty skills small molecule symposium treatment response web site website development

项目摘要

The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center’s scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.

行政核心由一组教职员工组成，他们将共同负责研究研究，中心的培训，计划和外展活动。我们的多学科，机构间的性质提案不仅对有效的科学管理授予溢价，而且为与其他组织的合作。利用这些机会是由 HMS系统药理学实验室（LSP），其中当前提案所基于的。 LSP是成立于2014年，旨在准确支持此处提出的系统生物学研究类型〜60：40实验室和计算研究之间。我们的管理计划反映了这样一种信念，即有效地应用系统生物学方法了解黑色素瘤，脑癌和乳腺癌中药物敏感性和抗性的预测因子需要参与具有计算生物学的潜水技能的研究人员的参与科学，生物信息学，系统生物学和统计推理。行政核心将支持该团队的努力并协助学生，博士后和初级教师成为系统的未来领导者癌症的生物学（AIM 1.1）。核心将有助于实验涉及的不同组的会议设计（AIM 4项目1； AIM 5项目2； AIM 6项目3）以及测量和分析方法由系统药理学核心执行（AIM 2）。它还将组织一个外部咨询委员会（AIM 1.2），协调中心飞行员赠款（AIM 1.2）并开发一个网站以共享有关中心的活动（AIM 1.1）并分发其结果和数据。管理核心将监视该中心的总体科学进步，并使用一般和特定于项目的指标（目标1.3）。最后，核心还将支持该中心在外展中的努力包括网站开发，培训以及与访问科学家的未来合作在内的活动（AIM 1.1）。本文所述的计划将确保调查人员之间有效的沟通和互动中心以及NCI和其他系统生物学中心。