Infectious Disease Genomics and Bioinformatics Training in Brazil

巴西传染病基因组学和生物信息学培训

• 批准号: 8112502
• 负责人: Jessica C Kissinger
• 金额: $ 15万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112502
• 关键词: Anopheles Genus; Area; Award; Bioinformatics; Biology; Brazil; Communicable Diseases; Complement; Complex; Data; Databases; Disease; Educational workshop; Epidemiology; Exercise; Funding; Generations; Genomics; Goals; Housing; Human; Knowledge; Laboratories; Maintenance; Molecular Evolution; Organism; Parasites; Parasitic Diseases; Pharmaceutical Preparations; Phase; Plasmodium; Population; Postdoctoral Fellow; Qualifying; Research; Research Infrastructure; Research Personnel; Research Project Grants; Schistosoma; Schistosoma mansoni; Schistosomiasis; Short-Term Course; Students; Technology; Toxoplasma gondii; Training; Training Programs; Trypanosoma cruzi; United States National Institutes of Health; Universities; Vaccines; design; genome database; meetings; public health relevance; training project; vector

DESCRIPTION (provided by applicant): This proposal represents a renewal of a current ITGH D43 collaborative training partnership between researchers at the University of Georgia, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro, the Universidade Federal de Minas Gerais and the Centro de Pesquisas Rene Rachou (CPqRR) - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 14 laboratories and 5 funded NIH research awards. The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH-funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR Is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans. This proposal is designed to meet the needs ofthe CPqRR by continuing a very productive training program that involves pre-and post-doctoral students from many of the 14 laboratories at the CPqRR for an additional 5 years. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the continued maintenance and extension (to include population diversity and other "omics" data) of a Schistosoma genome database created and housed the CPqRR during the first phase of the training award. Molecular evolution training will focus on the Schistosome vector, Blomphalaria and epidemiological/biostatistlcal data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a newly founded Center of Bioinformatics. PUBLIC HEALTH RELEVANCE: The need for new drug and vaccine targets for parasitic diseases is tremendous. Advances in technology have provided us with new data that cover many aspects of the biology of the parasites. But, the new data are complex and require sophisticated computational analyses and databases. This proposal is designed to train a new generation of researchers in endemic areas to use this new data to help cure disease.

描述（由申请人提供）：该提案代表了佐治亚大学、里约热内卢奥斯瓦尔多克鲁斯-FIOCRUZ研究所、米纳斯吉拉斯联邦大学和佩斯基萨斯中心的研究人员之间当前ITGH D43合作培训伙伴关系的更新。 Rene Rachou (CPqRR) - 巴西贝洛奥里藏特的 FIOCRUZ。 CPqRR 目前拥有 14 个实验室和 5 个 NIH 研究奖项。该培训计划的目标是在 CPqRR 生物信息学、流行病学和分子进化领域建立可持续的核心基础设施，以补充 NIH 资助的现有研究并促进其他实验室进行的研究。 CPqRR 的研究重点是热带寄生虫、其媒介和宿主。这些生物包括：疟原虫、克氏锥虫。弓形虫、曼氏血吸虫。按蚊、布氏疟原虫和人类。该提案旨在通过继续一项非常富有成效的培训计划来满足 CPqRR 的需求，该培训计划涉及 CPqRR 14 个实验室中许多实验室的博士前和博士后学生，为期额外 5 年。高级培训将通过巴西国内外的讲习班、课程、短期和长期培训进行。培训将涉及源自 CPqRR 需求的合作研究项目，重点关注血吸虫病的几个方面。本次培训的统一项目将是对血吸虫基因组数据库的持续维护和扩展（包括种群多样性和其他“组学”数据），该数据库在培训奖励的第一阶段创建并容纳了 CPqRR。分子进化培训将重点关注血吸虫载体、血吸虫，流行病学/生物统计数据将从现有资助的项目中获取和分析。从这次培训和实施活动中获得的技术和知识将直接应用于其他寄生生物的研究。我们将积极寻找合格的培训候选人，他们有强烈的回国愿望，并将他们新获得的专业知识贡献给新成立的生物信息学中心的延续。 公共卫生相关性：对寄生虫病新药和疫苗靶点的需求是巨大的。技术的进步为我们提供了涵盖寄生虫生物学许多方面的新数据。但是，新数据很复杂，需要复杂的计算分析和数据库。该提案旨在培训流行地区的新一代研究人员使用这些新数据来帮助治愈疾病。