Urban Diesel Exposure and Inner City Asthma

城市柴油暴露和内城哮喘

• 批准号: 7472464
• 负责人: RACHEL L MILLER
• 金额: $ 62.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-16 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472464
• 关键词: Adolescent; African American; Age; Air Pollutants; Air Pollution; Allergens; Allergic; Antigens; Area; Asthma; Birth; Carbon; Carbon Black; Child; Childhood Asthma; Data; Development; Diagnosis; Diesel Exhaust; Dominican; Environmental Exposure; Environmental Health; Environmental Tobacco Smoke; Exposure to; Goals; Health; Home environment; Hypersensitivity; Hypersensitivity skin testing; IgE; Intervention; Lead; Life; Lung; Malignant Neoplasms; Measurement; Measures; Medical Research; Monitor; New York; Outcome; Particulate Matter; Pollen; Protocols documentation; Recruitment Activity; Relative (related person); Reporting; Respiratory physiology; Risk; Serum; Symptoms; T-Cell Proliferation; Third Pregnancy Trimester; Trace metal; Urine; Week; air monitoring; atopy; base; cohort; inner city; member; pulmonary function; respiratory; trafficking

DESCRIPTION (provided by applicant): Living in areas with high volumes of motorized traffic has been associated with respiratory symptoms and deceased lung function in children. Based on both these epidemiological findings and supporting experimental data, exposure to diesel-related air pollution has potential for health concerns that include asthma and allergy. However, despite substantial gains in our recognition of likely diesel-induced asthmatic or allergic symptoms, direct associations between exposure to diesel-related air pollution and the onset of atopy and asthma in young children have not yet been demonstrated. The interaction of diesel exposure with other urban exposures on respiratory health also is not clear. We hypothesize that exposure to diesel emissions in Northern Manhattan and the South Bronx is associated with allergen-specific sensitization, decreased lung function, and the onset of asthma in children at age 5 through 6 years. Our strategy is to take advantage of an established inner city birth cohort in which multiple environmental exposures and health outcomes already are being measured to evaluate whether exposure to diesel-related air pollution independently, or jointly with other prevalent urban environmental exposures (allergens, environmental tobacco smoke [ETS]), increase the risk for the onset of atopy or asthma. Specifically, we propose to use our established cohort to: Aim 1. Determine whether exposure to diesel-related air pollution is associated with the onset of allergen-specific sensitization, decreased lung function and/or asthma at age 5 through 6 years, and Aim 2. Determine whether exposure to diesel-related air pollution interacts with a) allergen, and/or b) ETS exposure, on the onset of allergen-specific sensitization, decreased lung function and/or asthma at age 5-6 years. 300 Dominican and African American children residing in Northern Manhattan that are being followed prospectively since birth as part of Columbia Center for Children's Environmental Health will be recruited at age 5 through 6 years. Two-week air monitoring at home for PAHs, black carbon, mass, and trace metals will be performed. Repeat measures of PM25 and carbon will be repeated 6 months later. Outcomes include sera IgE, antigen-specific T cell proliferation, allergy skin tests, lung function, and asthma diagnosis. The primary goals are to determine whether diesel-related exposure can induce the development of allergy and/or asthma, and to identify its contribution relative to other urban exposures.

描述（由申请人提供）：生活在大量机动交通的地区与儿童的呼吸道症状和死亡的肺功能有关。基于这些流行病学发现和支持实验数据，与柴油相关的空气污染的暴露在于包括哮喘和过敏在内的健康问题。然而，尽管我们认识到柴油引起的哮喘或过敏症状的认识很大，但尚未证明与柴油相关的空气污染与柴油相关空气污染的直接关联与幼儿的特亚特和哮喘发作之间的直接关联尚未得到证明。柴油机暴露与其他城市呼吸健康状况的相互作用尚不清楚。我们假设曼哈顿北部和南布朗克斯的柴油排放的暴露与过敏原特异性敏化，肺功能降低以及5至6岁儿童的哮喘发作有关。 Our strategy is to take advantage of an established inner city birth cohort in which multiple environmental exposures and health outcomes already are being measured to evaluate whether exposure to diesel-related air pollution independently, or jointly with other prevalent urban environmental exposures (allergens, environmental tobacco smoke [ETS]), increase the risk for the onset of atopy or asthma.具体来说，我们建议使用我们已建立的队列来： AIM 1。确定暴露于柴油相关的空气污染是否与过敏原特异性敏化，5至6岁时的肺功能和/或哮喘的发作以及/或哮喘有关 AIM 2。确定暴露于柴油相关的空气污染是否与A）过敏原相互作用，和/或B）ETS暴露，在过敏原特异性敏化，肺功能下降和/或哮喘5-6岁时的发作。 自从哥伦比亚儿童环境健康中心的一部分以来，将有300名居住在曼哈顿北部的多米尼加和非洲裔美国儿童将在5至6岁时招募。将在家中为PAH，黑碳，质量和微量金属进行两周的空气监测。重复测量PM25和碳将在6个月后重复。结果包括血清IgE，抗原特异性T细胞增殖，过敏皮肤测试，肺功能和哮喘诊断。主要目标是确定与柴油相关的暴露是否可以引起过敏和/或哮喘的发展，并确定其相对于其他城市暴露的贡献。