MECHANISMS OF BIOORGANIC AND ORGANOMETALLIC CYCLIZATION REACTIONS

生物有机和有机金属环化反应的机制

• 批准号: 7601362
• 负责人: Dean Tantillo
• 金额: $ 0.03万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601362
• 关键词: Acids; Anabolism; Award; Biological Factors; Cations; Chemicals; Complex; Computer Retrieval of Information on Scientific Projects Database; Cyclization; DNA Sequence Rearrangement; Funding; Grant; Institution; Lipids; Methods; Molecular; Organic Chemicals; Reaction; Research; Research Personnel; Resources; Source; Terpenes; United States National Institutes of Health; base; chemical reaction; quantum

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of the research proposed herein, a renewal of CHE030089N, is to apply modern quantum chemical methods to the elucidation of molecular mechanisms of organic chemical reactions that are used in the synthesis and biosynthesis of polycyclic organic molecules. During this award period, we will concentrate on five subprojects: (project 1; continued from the previous grant period) cation-promoted biosynthetic polycyclization reactions leading to ladderane-containing bacterial lipids, (project 2; continued from the previous grant period) cation-promoted polycyclization reactions involved in biosyntheses of terpene natural products, (project 3; continued from the previous grant period) acid and base-promoted polyepoxide cyclizations involved in the biosynthesis of polyether natural products, (project 4; new) pericyclic cascade reactions used in the synthesis of complex heterocycles, and (project 5; expanded from the related project from the previous grant period) Ni and Pd-promoted sigmatropic rearrangements.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本文提出的研究重点是CHE030089N的更新，是将现代量子化学方法应用于阐明用于多环有机分子的合成和生物合成的有机化学反应的分子机制。在此资助期内，我们将集中精力开展五个子项目：（项目1；延续上一个资助期）阳离子促进的生物合成多环化反应，产生含梯烷的细菌脂质；（项目2；延续上一个资助期）阳离子-促进萜烯天然产物生物合成中涉及的多环化反应，（项目3；从上一个资助期继续）酸和碱促进的多环氧化物环化涉及聚醚天然产物的生物合成，（项目4；新）用于合成复杂杂环的周环级联反应，以及（项目5；从上一个资助期的相关项目扩展）Ni和Pd促进的σ重排。