IMPROVED ANALYTIC MODELS FOR ANALYSIS OF DCE-MRI DATA SETS

用于 DCE-MRI 数据集分析的改进分析模型

• 批准号: 7600828
• 负责人: MITCHELL D. SCHNALL
• 金额: $ 1.65万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600828
• 关键词: American College of Radiology Imaging Network; Brain Neoplasms; Colorectal Cancer; Computer Retrieval of Information on Scientific Projects Database; Data Set; Diagnostic Neoplasm Staging; End Point; Evaluation; Funding; Grant; Image; Institution; Kinetics; Magnetic Resonance Imaging; Modeling; Perfusion; Protocols documentation; Renal Cell Carcinoma; Research; Research Personnel; Resources; Source; Spectrum Analysis; Tumor stage; United States National Institutes of Health; bevacizumab; image reconstruction; improved; response; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analytic models for image reconstruction and analysis of DCE-MRI data sets in order to define kinetic parameters of tumor vascularity. These efforts will be applied toward central ACRIN DCE-MRI core lab analyses of several active imaging protocols which use DCE-MRI as an imaging endpoint. These include ACRIN-6676 (DCE-MRI for evaluation of renal cell carcinoma response to doublet targeted therapies), ACRIN 6677 (Brain tumor staging with perfusion MRI and spectroscopy), and ACRIN PA-4002 (DCE-MRI for evaluating early response of colorectal cancer to treatment with Bevacizumab).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 用于图像重建和 DCE-MRI 数据集分析的分析模型，以确定肿瘤血管分布的动力学参数。 这些工作将应用于中央 ACRIN DCE-MRI 核心实验室对几种使用 DCE-MRI 作为成像终点的主动成像协议的分析。 其中包括 ACRIN-6676（DCE-MRI，用于评估肾细胞癌对双药靶向治疗的反应）、ACRIN 6677（采用灌注 MRI 和光谱学进行脑肿瘤分期）和 ACRIN PA-4002（DCE-MRI，用于评估结直肠癌的早期反应）癌症到贝伐珠单抗治疗）。