The Johns Hopkins Physical Sciences Oncology Center

约翰霍普金斯大学物理科学肿瘤中心

• 批准号: 10016193
• 负责人: KENNETH J. PIENTA
• 金额: $ 202.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-29 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016193
• 关键词: Address; Adhesives; Arizona; Biological; Biomedical Engineering; Biophysics; Cancer Biology; Cancer Center; Cancer Patient; Cell Adhesion; Cells; Cessation of life; Clinical; Clinical Medicine; Collaborations; Collagen; Cues; DNA Sequence Alteration; Disseminated Malignant Neoplasm; Distant; Drug resistance; Ecology; Engineering; Epigenetic Process; Hypoxia; Individual; Laboratories; Leadership; Life; Mediating; Methods; Modification; Molecular; Neoplasm Metastasis; Oncology; Organ; Oxygen; Pennsylvania; Physics; Pilot Projects; Primary Neoplasm; Publishing; Role; Scientist; Therapeutic; Tumor Cell Invasion; Universities; Washington; anticancer research; biophysical techniques; cancer cell; epigenomics; extracellular; innovation; insight; mechanical force; medical schools; migration; outcome forecast; physical science; prevent; sarcoma; stem; success

In collaboration with cancer cell biologists at the Washington University School of Medicine and the University of Pennsylvania Abramson Cancer Center, as well as computational biophysicists at the University of Arizona, bioengineers and clinicians at Johns Hopkins University propose to create the Johns Hopkins Physical Sciences Oncology Center (PSOC). This PSOC will develop an integrated approach for a systematic, quantitative understanding of the forces mediating local invasion from the hypoxic primary tumor to distant organs, through single and collective invasion into the stromal matrix and confined migration along confining tracks, some of the early critical step in the metastatic cascade. To address the complexity of the combined effects of hypoxia, matrix microstructure and confinement on tumor cell invasion, we have developed three inter-related projects. Computational biophysicists will establish a computational core to systematically develop a quantitative understanding of forces in the metastatic cascade. PSOC projects will share innovative biophysical methods and experts. This PSOC takes a trans-disciplinary, integrated approach, combining the fields of physics, biomedical engineering, cancer biology, ecology, and clinical medicine, to transform our understanding of metastatic cancer, opening new paradigms for prognosis and treatment.

与华盛顿大学医学院和大学的癌细胞生物学家合作 宾夕法尼亚州艾布拉姆森癌症中心以及亚利桑那大学的计算生物物理学家 约翰·霍普金斯大学的生物工程师和临床医生建议创建约翰·霍普金斯物理 科学肿瘤学中心（PSOC）。该PSOC将为系统， 对介导从低氧原发性肿瘤局部侵袭的力的定量理解 器官，通过单一的集体入侵进入基质矩阵，并沿限制迁移 轨道，这是转移性级联的一些早期关键步骤。解决合并的复杂性 缺氧，基质微观结构和限制对肿瘤细胞侵袭的影响，我们已经发展了三个 相互关联的项目。计算生物物理学家将建立一个系统发展的计算核心 对转移级联反应的力的定量理解。 PSOC项目将分享创新 生物物理方法和专家。该PSOC采用跨学科的综合方法，结合了 物理，生物医学工程，癌症生物学，生态学和临床医学领域，以改变我们 了解转移性癌症，为预后和治疗打开新的范例。

项目成果

Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model

• DOI: 10.1016/j.actbio.2022.07.061
• 发表时间: 2022-09-29
• 期刊: ACTA BIOMATERIALIA
• 影响因子: 9.7
• 作者: Elliott, Morgan B.;Matsushita, Hiroshi;Gerecht, Sharon
• 通讯作者: Gerecht, Sharon

A self-healing hydrogel as an injectable instructive carrier for cellular morphogenesis.

• DOI: 10.1016/j.biomaterials.2018.09.003
• 发表时间: 2018-12
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Wei Z;Gerecht S
• 通讯作者: Gerecht S

Three-dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding.

• DOI: 10.1002/path.5474
• 发表时间: 2020-08
• 期刊: The Journal of pathology

Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.

差异 HDAC6 活性调节纤毛发生和随后源自多能干细胞的内皮细胞的机械传感。

• DOI: 10.1016/j.celrep.2018.06.083
• 发表时间: 2018
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Smith,Quinton;Macklin,Bria;Chan,XinYi;Jones,Hannah;Trempel,Michelle;Yoder,MervinC;Gerecht,Sharon
• 通讯作者: Gerecht,Sharon