CF 2: Biostatistics and Bioinformatics Core

CF 2：生物统计学和生物信息学核心

基本信息

批准号：
10016093
负责人：
Li-Xuan Qin
金额：
$ 15.95万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016093
关键词：
Address Advisory Committees Advocacy Attention Bioinformatics Biological Assay Biological Specimen Banks Biometry Biostatistics Core Cancer Center Cell Line Center Core Grants Characteristics Clinical Clinical Research Clinical Trials Clinical Trials Design Collaborations Consult Data Data Adjustments Data Analyses Data Set Databases Doctor of Philosophy Ensure Experimental Designs Formulation Goals Human Laboratory Research Manuscripts Memorial Sloan-Kettering Cancer Center Methodology Methods Molecular Analysis Molecular Profiling Pharmaceutical Preparations Phase Population Principal Investigator Procedures Protocols documentation Randomized Reporting Research Research Design Research Personnel Research Project Grants Sample Size Sampling Soft tissue sarcoma Statistical Data Interpretation Update Validation Writing base comparison group data exploration design laboratory experiment member molecular marker molecular scale novel predictive marker primary endpoint primary outcome protocol development research study response sarcoma secondary endpoint survival outcome translational cancer research tumor

项目摘要

Core 2: Biostatistics and Bioinformatics ABSTRACT The Biostatistics & Bioinformatics Core will support investigators of the Soft Tissue Sarcoma SPORE in the computational and statistical aspects of their research efforts, including the design and analysis of laboratory experiments, molecular profiling assays, and clinical trials. In laboratory experiments, core members will assist in the formulation of the experimental design and in the analysis and interpretation of the data at the conclusion of the study. The core will also assist in the large-scale molecular characterization of cell line and human tumor samples to identify predictors of tumor characteristics, drug response, and survival. In the clinical trial design phase, a core member will conduct a protocol review with the principal investigator; based on this review, a statistical section for the protocol will be provided, outlining major scientific objectives, population to be studied, primary and secondary endpoints, experimental design, analysis plans, and a targeted sample size justified in probabilistic terms; at the conclusion of the trial, data analyses will be performed to assess outcomes of the primary and secondary endpoints stated in the protocol. The core will perform statistical and bioinformatic analyses using appropriate state-of-the-art methodologies, and will develop alternative methods if current methodology does not adequately address a research question. In addition, the core will facilitate the management and updating of the clinical sarcoma database in collaboration with the leaders of research projects and the other three cores of the Soft Tissue Sarcoma SPORE.

核心2：生物统计学和生物信息学抽象的生物统计学和生物信息学核心将为软组织肉瘤孢子的研究人员提供支持他们的研究工作的计算和统计方面，包括设计和分析实验室实验、分子谱分析和临床试验。在实验室实验中，核心成员将协助制定实验设计以及分析和解释研究结束时的数据。该核心还将协助大规模分子细胞系和人类肿瘤样本的表征，以确定肿瘤特征的预测因子，药物反应和生存。在临床试验设计阶段，核心成员将进行方案与主要研究者一起审查；根据这一审查，该议定书的统计部分将是提供，概述主要科学目标、要研究的人群、小学和中学终点、实验设计、分析计划和概率合理的目标样本量条款；试验结束时，将进行数据分析以评估主要结果和方案中规定的次要终点。核心将执行统计和生物信息学使用适当的最先进的方法进行分析，并将开发替代方法目前的方法并不能充分解决研究问题。此外，该核心将有助于与以下国家领导人合作管理和更新临床肉瘤数据库研究项目和软组织肉瘤孢子的其他三个核心。