Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls

青春期女孩人际压力产生和抑郁风险的大脑行为预测因素

• 批准号: 10704711
• 负责人: Cope Feurer
• 金额: $ 20.21万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704711
• 关键词: Adolescence; Adolescent; Adult; Affective; Age; Area; Behavior; Behavioral; Behavioral Mechanisms; Biological; Brain; Chicago; Coupled; Cues; Data; Detection; Development; Down-Regulation; Early Diagnosis; Ecological momentary assessment; Enrollment; Environment; Etiology; Exhibits; Family; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Grain; Grant; Illinois; Individual; Intervention; Interview; Life Stress; Link; Major Depressive Disorder; Mediating; Mediator; Mental Depression; Mentorship; Methodology; Modeling; Moods; Morbidity - disease rate; National Institute of Mental Health; Neurobiology; Nucleic Acid Regulatory Sequences; Onset of illness; Parents; Patient Self-Report; Peripheral; Prevention; Process; Recording of previous events; Recurrence; Regulation; Reporting; Research; Risk; Risk Factors; Role; Sampling; Self Assessment; Social Interaction; Social Processes; Statistical Methods; Stress; Stressful Event; Suicide; Techniques; Testing; Time; Training; Universities; Variant; Work; Youth; affective neuroscience; behavior prediction; career; child depression; depression prevention; depressive symptoms; design; disorder risk; follow-up; girls; imaging study; improved; indexing; multilevel analysis; negative affect; neural; neural correlate; neural patterning; neuroimaging; neuromechanism; novel; peer; prospective; response; skill acquisition; skills; social; social exclusion; social stress; stressor; theories; translational scientist

Risk for major depressive disorder (MDD) onset dramatically increases during adolescence, particularly for girls. There is a vital need to elucidate the underlying mechanisms of MDD risk to improve early risk detection and targeted preventions. The stress generation model posits interpersonal stress generation (I-StressGen) as a mechanism of risk and proposes that youth with preexisting MDD vulnerabilities actively contribute to the occurrence of interpersonal stressful life events in their lives (i.e., I-StressGen), which in turn exacerbates their risk for MDD. Although the impact of I-StressGen on prospective MDD risk in adolescents is well-established, the precise mechanisms contributing to I-StressGen remain unclear. Self-report research indicates increased affective reactivity during negative social interactions as a promising mechanism contributing to I-StressGen, though this has not been directly tested. The underlying neural mechanisms of I-StressGen also remain unexamined, despite work suggesting that greater social stress is associated with aberrant activation in corticolimbic regions during tasks probing response to negative social interactions. Therefore, the overarching goal of the proposed study is to obtain a fine-grained, mechanistic understanding of the role of brain and behavioral affective reactivity during negative social interactions as it relates to I-StressGen and subsequent MDD risk in female adolescents. The proposed study will enroll a risk-enhanced sample of 90 female adolescents (ages 13-15) and will utilize neuroimaging (fMRI) and ecological momentary assessment (EMA) to examine brain and behavior indices of socio-affective reactivity as predictors of I-StressGen and depression symptoms across a multi-wave one year follow-up. In doing so, the current study will test whether affective reactivity during negative social interactions at the neural (Aim 1) and real-world behavioral (Aim 2) level prospectively predicts I- StressGen, and whether I-StressGen mediates the relation between this socio-affective reactivity and prospective increases in female adolescents’ depression symptoms (Aim 3). The proposed study and parallel training plan will allow the Candidate to build upon her current expertise in adolescent stress and MDD risk and develop new skills in four key areas: (1) fMRI, (2) EMA, (3) advanced statistical multilevel modeling, and (4) professional development. The rich academic environment at the University of Illinois at Chicago coupled with the collective expertise of the Candidate’s mentorship team in fMRI methodology, developmental affective neuroscience, EMA, and advanced statistical techniques will facilitate successful implementation of the proposed study and training plan. The acquisition of these skills will be integral to launching the Candidate’s independent career as a translational scientist focused on delineating brain-behavioral mechanisms of adolescent MDD risk within the context of real-world interpersonal stress. Results from this study will inform the development of future grants focused on characterizing socio-affective brain and behavior mechanisms and aberrant developmental trajectories contributing to the emergence of maladaptive stress processes and MDD onset in adolescence.

在青少年期间，尤其是针对女孩，重大抑郁症（MDD）发作的风险大大增加。 至关重要的是阐明MDD风险的潜在机制，以改善早期风险检测和 有针对性的预防。压力产生模型将人际应力产生（I-Surtsgen）视为 风险和提议的机制，即先前存在的MDD脆弱性的青年积极促进 人生中的人际压力性生活事件发生（即i-sursten），这反过来又加剧了他们的 MDD的风险。尽管i-surstergen对青少年的预期MDD风险的影响是公认的，但 造成I压力的确切机制尚不清楚。自我报告研究表明增加 负面社交互动期间的情感反应性是有助于I压力的承诺机制， 尽管尚未直接测试。 i压力带的潜在神经机制也仍然存在 未经审查的任务工作表明，更大的社会压力与异常激活有关 在探测对负面社会互动的反应的任务过程中，皮质的区域。因此，总体 拟议的研究的目标是获得对大脑和大脑作用的细粒度，机械理解 负面社交互动期间的行为情感反应性与I压力相关，随后 女性青少年的MDD风险。拟议的研究将招募90名女性青少年的风险增强样本 （13-15岁），并将利用神经影像学（fMRI）和生态瞬时评估（EMA）检查大脑 社会影响反应性的行为指数，作为I压力器和抑郁症状的预测指标 一年的多波浪随访。这样，当前的研究将测试阴性期间的情感反应性 神经（目标1）和现实世界行为（AIM 2）的社会互动前景预测I- 压力基，以及我的压力符号是否介导了这种社会影响反应性与 女性青少年抑郁症状的前瞻性增加（AIM 3）。拟议的研究和平行 培训计划将使候选人能够以她目前在青少年压力和MDD风险和MDD风险方面的专业知识为基础 在四个关键领域开发新技能：（1）fMRI，（2）EMA，（3）高级统计多级建模和（4） 专业发展。伊利诺伊大学芝加哥大学的丰富学术环境以及 FMRI方法论候选人精神制度团队的集体专家发展了情感 神经科学，EMA和高级统计技术将有助于成功实施拟议的 学习和培训计划。这些技能的获取将是启动候选人独立的必不可少的 作为翻译科学家的职业，重点是描述青少年MDD风险的脑行为机制 在现实世界中的人际压力的背景下。这项研究的结果将为未来的发展提供信息 赠款的重点是表征社会影响的大脑和行为机制和异常发展 有助于不良适应应力过程和青少年发作的轨迹。