CONSTRUCTION OF NOVEL PEPTOID ARCHITECTURES

新型类肽结构的构建

• 批准号: 7598700
• 负责人: Helen E. Blackwell
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598700
• 关键词: Adopted; Amides; Amines; Architecture; Computer Retrieval of Information on Scientific Projects Database; Facility Construction Funding Category; Funding; Grant; Homologous Gene; Institution; Molecular Conformation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A straightforward synthesis has been developed for (S)-N-1-(pentafluorophenyl)ethyl amine that holds promise as a valuable chiral building block for the construction of novel peptoid architectures. This amine was incorporated successfully into a peptoid pentamer with alternating aromatic/perfluoroaromatic amide substituents. Structural characterization revealed that the peptoid pentamer can adopt a well-defined helical conformation analogous to that observed for considerably longer peptoid homologues.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 (S)-N-1-(五氟苯基)乙胺的直接合成方法已经开发出来，有望成为构建新型类肽结构的有价值的手性构件。该胺成功地掺入具有交替芳族/全氟芳族酰胺取代基的类肽五聚体中。结构表征表明，类肽五聚体可以采用明确的螺旋构象，类似于在相当长的类肽同源物中观察到的结构。