5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center

5/14 APOL1长期肾移植结果网络（APOLLO）临床中心

• 批准号: 10731162
• 负责人: Sumit Mohan
• 金额: $ 18.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731162
• 关键词: APOL1 gene; Acceleration; Acute; Address; African American; African ancestry; Albumins; Allografting; American; Antibodies; Apolipoproteins; Bacterial Infections; Biopsy; Black race; Blood; Clinical; Clinical Data; Clinical Investigator; Collaborations; Collection; Consent; Cost Savings; Counseling; Creatinine; DNA; Data; Data Set; Disparity; Donor person; Education; Enrollment; Ensure; Environmental Risk Factor; Epidemiology; European; Evaluation; Face; Failure; Future; Genes; Genetic; Genotype; Geography; Goals; Graft Survival; HLA Antigens; Health; Health Care Costs; Healthcare; Hispanic; Immunology; Immunosuppression; Individual; Infrastructure; Kidney; Kidney Failure; Kidney Transplantation; Lesion; Living Donors; Longterm Follow-up; Measures; Medical; Medical center; Meridians; New England; Organ; Outcome; Outcomes Research; Participant; Pattern; Pediatric Hospitals; Pennsylvania; Phase; Phenotype; Philadelphia; Policies; Prevalence; Proteinuria; Quality of life; Recording of previous events; Recurrent disease; Registries; Renal function; Reporting; Research; Resources; Risk; Role; Safety; Serum; Site; Slide; Time; Transplant Recipients; Transplantation; United Network for Organ Sharing; United States National Institutes of Health; Universities; Urine; Variant; Virus Diseases; clinical center; cohort; data registry; digital pathology; ethnic difference; experience; follow-up; gene interaction; genetic risk factor; graft failure; high risk; improved; kidney biopsy; living kidney donor; member; multidisciplinary; novel; patient retention; post-transplant; primary outcome; programs; prospective; racial difference; recruit; repository; risk variant; secondary outcome; transplant centers

ABSTRACT The Columbia-Penn Clinical Consortium APOLLO-CC05 brings together an experienced multidisciplinary team of clinical investigators with expertise in the fields of transplant epidemiology, immunology, and genetics, as well as an extensive history of collaboration with the United Network for Organ Sharing (UNOS) and other CPCC member transplant programs. As a result, the CC05 is well suited to recruit and retain patients for longitudinal follow up for the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO) Phase 2. This Clinical Center is composed of 11 transplant centers in four contiguous states (NY, NJ, CT and PA) in the Northeastern US. Our primary objective is to provide long-term follow up data on all APOLLO Phase 1 participants while continuing to enroll new African American or Black Hispanic living kidney donors (Aim 1). We will provide detailed clinical data (not currently available in any registry dataset) with the goal of identifying “second hits” and collect additional biospecimens (Urine albumin to creatinine ratio, blood, urine and biopsy slides) for Aim 2. We will partner with the SDRC to provide return of APOL1 genotype results to all participants who wish to receive them (Aim 3). We expect that Phase 2 of the APOLLO study will determine the impact of APOL1 risk variants in donors and recipients on kidney transplant outcomes and will create a unique cohort of African American living kidney donors with detailed clinical data and biospecimens as a resource for future studies.

抽象的 哥伦比亚-宾夕法尼亚大学临床联盟 APOLLO-CC05 汇集了经验丰富的专家 由具有移植领域专业知识的临床研究人员组成的多学科团队 流行病学、免疫学和遗传学，以及与 器官共享联合网络 (UNOS) 和其他 CPCC 成员移植计划。 因此，CC05 非常适合招募和留住患者进行纵向随访 APOL1 长期肾移植结果研究网络 (APOLLO) 第 2 阶段。 该临床中心由位于四个相邻州（纽约州、新泽西州、康涅狄格州）的 11 个移植中心组成 和 PA）在美国东北部的主要目标是提供长期跟踪数据。 所有 APOLLO 第一阶段参与者，同时继续招募新的非裔美国人或黑人 西班牙裔活体肾脏捐赠者（目标 1）。我们将提供详细的临床数据（目前不提供）。 任何注册表数据集中都有），目的是识别“第二次点击”并收集额外的信息 目标 2 的生物样本（尿白蛋白与肌酐比、血液、尿液和活检切片）。我们 将与 SDRC 合作，向所有参与者提供 APOL1 基因型结果返回 希望收到它们（目标 3）。我们预计 APOLLO 研究的第二阶段将确定 供体和受者 APOL1 风险变异对肾移植结果的影响 创建一个独特的非裔美国人活体肾脏捐赠者队列，提供详细的临床数据和 生物样本作为未来研究的资源。

项目成果

Reversal of Donor Hepatitis C Virus-Related Mesangial Proliferative GN in a Kidney Transplant Recipient.

肾移植受者体内供体丙型肝炎病毒相关的系膜增殖性肾小球肾炎的逆转。

• DOI: 10.1681/asn.2020060820
• 发表时间: 2020
• 期刊: Journal of the American Society of Nephrology : JASN
• 作者: Khairallah,Pascale;Kudose,Satoru;Morris,HeatherK;Ratner,LloydE;Mohan,Sumit;Radhakrishnan,Jai;Chang,Jae-Hyung
• 通讯作者: Chang,Jae-Hyung

Radical Transparency to Improve Equity in the Kidney Allocation System.

• DOI: 10.34067/kid.0000000000000327
• 发表时间: 2024-01-01
• 期刊: Kidney360
• 作者: Husain SA;Adler JT;Mohan S
• 通讯作者: Mohan S

Trends in Transplantation Center Use of Kidneys From Deceased Donors With Positive Hepatitis C Virus Nucleic Acid Testing.

• DOI: 10.1053/j.ajkd.2020.04.008
• 发表时间: 2020-11
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: King KL;Husain SA;Mohan S
• 通讯作者: Mohan S

Deceased donor kidneys allocated out of sequence by organ procurement organizations.

• DOI: 10.1111/ajt.16951
• 发表时间: 2022-05
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Continuous renal replacement therapy and the COVID pandemic.

• DOI: 10.1111/sdi.12962
• 发表时间: 2021-11
• 期刊: Seminars in dialysis
• 影响因子: 1.6
• 作者: Stevens JS;Velez JCQ;Mohan S
• 通讯作者: Mohan S