Pilot Projects and Trans-Network Activities Core

试点项目和跨网络活动核心

• 批准号: 10732992
• 负责人: Brian Andrew Van Tine
• 金额: $ 2.89万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10732992
• 关键词: Award; Bioinformatics; Cancer Center; Cancer Therapy Evaluation Program; Clinical Trials; Collaborations; Development; Early Therapeutic-Clinical Trials Network; Electronic Mail; Fostering; Funding; Goals; Grant; Institution; Life; Mentors; Mission; Newsletter; Pilot Projects; Pre-Clinical Model; Process; Reproducibility; Research; Research Methodology; Research Personnel; Research Project Grants; Review Committee; Translating; Translational Research; Underrepresented Minority; Universities; Validation; Washington; Woman; Work; anticancer research; human disease; innovation; minority investigator; new technology; patient derived xenograft model; patient subsets; pre-clinical; programs; recruit; research and development; translational goal

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE - SUMMARY The goal of the Pilot Projects and Trans-Network Activities Core is to support the development of research projects using PDX models that will advance the mission of the PDTC and PDXNet. The core will help to foster collaborative, translational research both within the PDTC and across the PDXNet by establishing two annual $50,000 awards. The goal of these supported projects will be to support the translational goals of the PDTC to advance translational research through the use of PDX models or, research methods to enhance experimental validation and reproducibility across PDTCs and the PDXNet. Pilot projects may support the development and integration of new technologies into the PDXNet program. Collaborative, PDXNet pilot projects may also be used for Cross-Network studies to establish best practice standards for research using PDX models. The Core will also engage non-PDXNet investigators, providing collaborative opportunities to use well-characterized PDX models that recapitulate human disease and further the reach of the NCI PDXNet program.

试点项目和跨网络活动核心 - 摘要 试点项目和跨网络活动核心的目标是支持研究的发展 使用 PDX 模型的项目将推进 PDTC 和 PDXNet 的使命。核心将有助于培育 通过建立两个年度项目，在 PDTC 和整个 PDXNet 内开展协作、转化研究 奖金 50,000 美元。这些支持项目的目标是支持 PDTC 的转化目标 通过使用 PDX 模型或增强实验的研究方法来推进转化研究 跨 PDTC 和 PDXNet 的验证和再现性。试点项目可以支持发展和 将新技术集成到 PDXNet 计划中。也可以使用协作 PDXNet 试点项目 用于跨网络研究，为使用 PDX 模型的研究建立最佳实践标准。核心将 还吸引非 PDXNet 研究人员，提供使用特征良好的 PDX 的协作机会 概括人类疾病的模型并进一步扩大 NCI PDXNet 计划的影响范围。