Building capacity for Global Infectious Disease Research Training in Schistosomiasis in sub-Saharan Africa

撒哈拉以南非洲血吸虫病全球传染病研究培训能力建设

• 批准号: 10731399
• 负责人: Alison Elliott
• 金额: $ 10.83万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-18 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731399
• 关键词: Adult; Advisory Committees; Affect; Africa South of the Sahara; Artificial Intelligence; Behavior; Biology; Charge; Collaborations; Communities; Computational Biology; Country; Data; Data Science; Development; Disease Management; Disease Surveillance; Environment; Epidemiology; Exposure to; Faculty; Gastrointestinal Hemorrhage; Genomics; Goals; Grant; Health; Health Sciences; Immunity; Immunology; Infection; Infectious Diseases Research; Institution; Interdisciplinary Study; International; Intervention; Methodology; Modeling; Monitor; Needs Assessment; Population; Preparation; Prevention; Process; Production; Research; Research Institute; Research Training; Resources; Risk; Schistosoma; Schistosomiasis; Scientific Advances and Accomplishments; Scientist; Severity of illness; Therapeutic; Training; Training Programs; Uganda; Universities; Virus; Washington; career; college; design; disorder control; innovation; medical schools; multidisciplinary; organizational structure; programs; transmission process; vaccine candidate; vaccinology; vector; vector control; virtual

Program abstract This is an application for a two-year planning grant to build capacity for an international advanced research training in schistosomiasis in Uganda. The high burden of schistosomiasis in Uganda persists since the 1950’s Over 50% of the Ugandan population is at risk of exposure to Schistosoma species and its complications of fatal upper gastro-intestinal bleeding among adults. Gaps in control of schistosomiasis remain due to limited number of scientists with capacity to conduct advanced research and training focused on schistosomiasis epidemiology, vector biology, immunology, vaccinology, therapeutics, genomics, computational biology to model the schistosomiasis transmission, data science and artificial intelligence to model population behavior and other predictors of disease severity, as well as local development and production of effective vaccine candidates, and the application of locally generated data to inform relevant interventions for disease surveillance and control interventions in the affected communities. We propose to conduct a comprehensive needs assessment of the existing research and training capacity for schistosomiasis at Makerere University College of Health Sciences (MakCHS) and the collaborating institutions in Uganda (Uganda Virus Research Institute-UVRI, the Ministry of Vector Control Division in charge of schistosomiasis and other medical schools in the country). Findings from the needs assessment will be used to develop of an innovative research training and career enhancement program to strengthen capacity of scientists and health research professionals to conduct independent, multi-disciplinary research in schistosomiasis. During the two-year planning period we will hold multiple stakeholder engagements and identify the research training resources, local and international faculty, scientific environment contributions and administrative processes needed to undertake a schistosomiasis research training program. We will establish a strong executive committee to oversee the design and preparation of advanced scientific didactic and methodology courses (physical and virtual) and research training resources for schistosomiasis epidemiology, disease management, prevention, and control. We will also establish an international multi- disciplinary training advisory committee that will meet quarterly to guide and monitor the progress of the planning process against the set goals and milestones. The proposed planning grant will build on existing infection and immunity research training partnerships between MakCHS and UVRI, and long-standing research training collaborations with our US partners (John Hopkins University and University of Washington). We will reach out for new collaborations that may be required locally and abroad to establish a wholistic, multi-disciplinary network of scientists with an effective organizational structure that will support the envisioned research training program, and resultant collaborative five-year training program (D43) application for better control schistosomiasis in Uganda. 1

程序摘要 这是一项为期两年计划赠款的申请，以建立国际高级研究的能力 乌干达的血吸虫病培训。自从 1950年以上的50％的乌干达人口有暴露于血吸虫物种及其的风险 成年人致命上胃肠道出血的并发症。控制血吸虫病的差距 由于有限数量的科学家，其能力进行了高级研究和培训的能力 关于血吸虫病流行病学，载体生物学，免疫学，疫苗学，治疗，基因组学，， 计算生物学，以对血吸虫病的传播，数据科学和人工智能进行建模 建模人口行为和疾病严重程度以及地方发展的其他预测指标 生产有效的疫苗候选物，以及当地生成的数据的应用以告知相关 受影响社区的疾病监测和控制干预措施的干预措施。我们建议 对现有研究和培训能力进行全面需求评估 Makerere大学健康科学学院（Makchs）和合作 乌干达的机构（乌干达病毒研究所 - UVRI，媒介控制部 该国的血吸虫病和其他医学院的指控）。需求评估的发现 将用于制定创新的研究培训和职业增强计划，以加强 科学家和卫生研究专业人员的能力进行独立的多学科研究 在血吸虫病中。在为期两年的计划期内，我们将举行多个利益相关者的参与和 确定研究培训资源，地方和国际教师，科学环境贡献 和行政流程需要进行血吸虫病研究培训计划。我们将 建立一个强大的执行委员会来监督高级科学教学的设计和准备 和方法学课程（物理和虚拟）以及血吸虫病的研究培训资源 流行病学，疾病管理，预防和控制。我们还将建立一个国际多的 纪律培训咨询委员会将举行每季度开会，以指导和监视 规划针对既定目标和里程碑的过程。拟议的规划赠款将建立在现有的基础上 Makchs和UVRI之间的感染和免疫学研究培训伙伴关系，以及长期存在 与我们的美国合作伙伴（约翰·霍普金斯大学和华盛顿大学）的研究培训合作。 我们将联系新的合作，这些合作可能是在本地和国外需要的，以建立一个全面的合作 具有有效组织结构的科学家的多学科网络，将支持 设想的研究培训计划以及由此产生的合作五年培训计划（D43）申请 为了更好地控制乌干达的血吸虫病。 1