PDX Core

PDX核心

基本信息

批准号：
10733312
负责人：
JENNIFER E KOBLINSKI
金额：
$ 30.1万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-19 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733312
关键词：
Advanced Malignant Neoplasm Archives Bioinformatics Biological Specimen database Black Populations Black race Breast Cancer Center Carcinomatosis Characteristics Clinical Collaborations Collection Communication Communities Data Data Commons Development Diagnosis Educational workshop Equity Genitourinary system Genomics Gynecologic Health Disparities Research Histologic Investigation Latinx Libraries Link Lung Malignant Neoplasms Massey Cancer Center at the Virginia Commonwealth University Minority Groups Modeling Molecular Organoids Pancreas Pancreatic Adenocarcinoma Patients Peritoneal Pilot Projects Population Preclinical Testing Primary Neoplasm Program Research Project Grants Quality of Care RNA Research Research Project Grants Research Support Sampling Site Specimen System Tissue Expansion Tissue Harvesting Tumor Tissue Underrepresented Minority Underrepresented Populations Universities Virginia advanced system cancer subtypes cancer type central database ethnic diversity ethnic minority population gastrointestinal health equity immunohistochemical markers improved malignant breast neoplasm meetings multiple omics operation patient derived xenograft model patient population personalized approach programs racial diversity racial minority population relational database repository safety net therapeutic development tumor

项目摘要

PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in all cancer types, especially those from underrepresented minority groups with more aggressive, recalcitrant and/or advanced clinical stages. The overall objectives of United for Health Equity in Living PDX Program (U4HELPP) will be to increase diverse representation and study of racial/ethnic minority populations through development and investigations on more racial/ethnically diverse patient-derived xenograft models (PDX) to advance cancer health disparity research. The U4HELPP PDX Core will serve as a central point for patient-derived viable tumor tissue harvest and expansion to fully support Research Projects 1 & 2 and Pilot Project and Trans-network Activities Core. The U4HELPP PDX Core will also serve as a central database of these specimens with clinical and molecular characteristics, including ancestry, of each cancer subtype, linked to molecular genomics.

项目摘要 /摘要 U4HELPP PDX核心对癌症治疗发展的个性化方法的深刻局限性是缺乏相关的所有癌症类型的患者衍生模型，尤其是来自代表性不足的少数群体的模型侵略性，顽固和/或晚期临床阶段。联合卫生平等目标的总体目标 Living PDX计划（U4HELPP）将增加种族/族裔少数民族的各种代表性和研究通过开发和调查更多种族/种族多样性的患者衍生异种移植物的人群模型（PDX），以提高癌症健康差异研究。 U4HELPP PDX核心将作为中心用于患者来源的可行肿瘤组织收获和扩张，以完全支持研究项目1和2 项目和跨网络活动核心。 U4HELPP PDX核心也将作为中央数据库这些具有临床和分子特征的标本，包括每个癌症亚型的祖先分子基因组学。