Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers

转移性乳腺癌和前列腺癌的组学和多维空间图谱

• 批准号: 9788352
• 负责人: JOE W. GRAY
• 金额: $ 32.7万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9788352
• 关键词: Administrator; Advisory Committees; Atlases; Benchmarking; Big Data to Knowledge; Biology; Clinical; Clinical Data; Clinical Trials; Collaborations; Communication; Communities; Computer software; Conflict (Psychology); Data; Data Analyses; Data Coordinating Center; Development; Disputes; Emerging Technologies; Ensure; Evaluation; Event; Funding; Goals; Human; Human Resources; Image; Image Analysis; Informed Consent; Infrastructure; Institutional Review Boards; Intellectual Property; Lead; Leadership; Logistics; Malignant Neoplasms; Malignant neoplasm of prostate; Metastatic breast cancer; Microscopy; Network Infrastructure; Office of Administrative Management; Policies; Publications; Quality Control; Reporting; Research; Research Personnel; Resolution; Resource Sharing; Resources; Review Committee; Sampling; Scientific Evaluation; Site; Site Visit; System; Systems Biology; Technology; The Cancer Genome Atlas; Time; Tissues; Training; United States National Institutes of Health; Work; adjudicate; analytical tool; computational atlas; computer infrastructure; data access; data acquisition; data sharing; instrumentation; light microscopy; meetings; member; multidisciplinary; new technology; programs; quality assurance; resistance mechanism; symposium; technology development; therapy resistant; tumor; user-friendly; web site; working group

ABSTRACT - Administrative Core The Administrative Core will serve as the organization, integration, and evaluation hub of the OMS Atlas. This Core provides leadership, and supports and coordinates: (a) communications and integration within the OMS Atlas and with the Human Tumor Atlas Network (HTAN); (b) proposal management, reporting, and compliance activities; (c) oversight of budgetary and intellectual property issues; (d) unit milestone evaluation and integration, and coordination with the SMMART Clinical Trial; (e) trans-HTAN projects; (f) organization of the biomedical use case working group; (g) oversight of the OMS Atlas computational infrastructure and the Data and Resource Sharing Plan; (h) data access and publication plans, including dispute resolution; and (i) HTAN and External Advisory Committee (EAC) review. The Administrative Core will be led by Dr. Joe Gray (Contact Program Director/PI, and Characterization Unit Lead); Dr. Gordon Mills (PD/PI, SMMART Clinical Trial Director, and co-Lead Biospecimen Unit); Dr. Chris Corless (PD/PI and Lead Biospecimen Unit); Dr. Jeremy Goecks (PD/PI and Lead of the Data Analysis Unit); and Center Administrator, Dr. Heidi Feiler. Drs. Annette Kolodzie and Brett Johnson will manage integration of the SMMART clinical trial component, and biospecimen and data sharing, respectively, across the units. This Core will coordinate OMS Atlas participation in the HTAN programmatic meetings, such as HTAN Steering Committee meetings, annual Investigators meetings and site visits. For planning and evaluation, it will organize OMS Atlas meetings, including monthly unit progress meetings and Executive Committee meetings, and quarterly Steering Committee meetings, comprised of all key personnel. Meetings will be video conferenced to facilitate participation and discussion. In addition, the Administrative Core will oversee the Data and Resource Sharing Plan and development of the data networking infrastructure platform in the Analysis Unit that will integrate with the HTAN-Data Coordinating Center (HTAN- DCC) and the HTAN-Tissue Coordinating Center. The Administrative Core will coordinate publications of analyses of the OMS data that reveal specific resistance mechanisms. It will oversee trans-HTAN project development in collaboration with the OMS Atlas EAC and the HTAN. The Administrative Core will organize annual EAC meetings to provide guidance on OMS Atlas activities. This review will be coordinated with an annual retreat and HTAN site visit so the external advisors and HTAN leadership will have the opportunity to interact with researchers from all OMS Atlas sites. To facilitate collaboration, PIs from other HTAN centers, the HTAN-DCC and leaders of major cancer analysis generating programs (e.g., Cancer Systems Biology Consortium (CSBC), LINCS, PS-ON, TCGA, ICGC, BD2K, and CTD2) will also be invited. In summary, the Administrative Core will support and integrate activities between the Clinical Leads, Use Case Biology Leads, and across the Biospecimen, Characterization and Data Analysis Units, which collectively form the OMS Atlas, and coordinate these activities with tissue accrual and management through the SMMART Program.

摘要 - 行政核心 行政核心将充当OMS地图集的组织，集成和评估中心。这 核心提供领导和支持和坐标：（a）OMS中的沟通和集成 地图集和人类肿瘤网络（HTAN）； （b）提案管理，报告和合规性 活动; （c）监督预算和知识产权问题； （d）单位里程碑评估和 与SMMART临床试验的整合和协调； （e）Trans-Htan项目； （f）组织 生物医学用例工作组； （g）对OMS ATLAS计算基础架构的监督和数据 和资源共享计划； （h）数据访问和出版计划，包括争议解决； （i）htan 和外部咨询委员会（EAC）审查。行政核心将由Joe Gray博士领导（联系人 程序总监/PI和表征单元的铅）； Gordon Mills博士（PD/PI，SMMART临床试验 董事和共同领导的生物传播单位）； Chris Corless博士（PD/PI和Lead Biospecececececececemen单位）；杰里米博士 Goecks（PD/PI和数据分析单元的铅）；和中心管理员Heidi Feiler博士。博士。安妮特 Kolodzie和Brett Johnson将管理SMMART临床试验组件的整合和BioSpecimen 和数据共享分别跨单元。该核心将协调OMS地图集参加HTAN 计划会议，例如HTAN指导委员会会议，年度调查人员会议和现场 访问。为了计划和评估，它将组织OMS地图集会议，包括每月单位进度 会议和执行委员会会议以及季度指导委员会会议，由所有人组成 关键人员。会议将举行会议，以促进参与和讨论。另外， 行政核心将监督数据网络的数据和资源共享计划和开发 分析单元中的基础架构平台将与HTAN-DATA协调中心集成（HTAN- DCC）和HTAN-TISSUE协调中心。行政核心将协调 对揭示特定抗性机制的OMS数据的分析。它将监督Trans-Htan项目 与OMS Atlas EAC和HTAN合作开发。行政核心将组织 年度EAC会议，以提供有关OMS Atlas活动的指导。这篇评论将与 年度务虚会和HTAN网站访问，因此外部顾问和HTAN领导人将有机会 与来自所有OMS ATLAS网站的研究人员互动。为了促进合作，来自其他HTAN中心的PI， HTAN-DCC和主要癌症分析生成计划的领导者（例如，癌症系统生物学 还将邀请财团（CSBC），Lincs，PS-ON，TCGA，ICGC，BD2K和CTD2）。总而言之， 行政核心将支持和整合临床线索之间的活动，用例生物学潜在客户， 在整个生物测量中，表征和数据分析单元，这些单元统称为OMS Atlas， 并通过SMMART计划与组织应计和管理协调这些活动。