Approach Bias Modification for Co-Occurring Cannabis and Alcohol Use among Treatment-Seeking Adolescents

针对寻求治疗的青少年同时吸食大麻和酗酒的方法偏差修正

• 批准号: 10375380
• 负责人: Austin Matthew Hahn
• 金额: $ 20.9万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10375380
• 关键词: Adolescence; Adolescent; Adult; Aftercare; Age; Alcohol abuse; Alcohol consumption; Alcohols; Area; Award; Behavioral; Brain; Cannabis; Categories; Clinical Trials; Cognitive; Communication; Computers; Cues; Data; Development; Development Plans; Drug Exposure; Ecological momentary assessment; Effectiveness; Electroencephalogram; Electroencephalography; Ensure; Environment; Etiology; Evaluation; Event-Related Potentials; Exhibits; Funding; Goals; Image; Intervention; Joystick; Knowledge; Maintenance; Measures; Mediating; Mediator of activation protein; Mentors; Mentorship; Methods; Modification; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Neurocognitive; Neurologic; Participant; Performance; Pharmaceutical Preparations; Play; Portraits; Positioning Attribute; Process; Productivity; Publications; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Resources; Rewards; Role; SECTM1 gene; Stimulus; Strategic Planning; Structure; Testing; Time; Training; addiction; adolescent substance use; alcohol effect; alcohol use disorder; brief intervention; career; career development; computerized; cost; craving; design; emerging adult; experience; experimental study; implicit bias; innovation; intervention effect; marijuana use; marijuana use disorder; marijuana user; neglect; post intervention; programs; prospective; response; substance use; substance use treatment; underage drinker; underage drinking

PROJECT SUMMARY/ABSTRACT Alcohol and cannabis are the first and second most commonly used substances among adolescents. Adolescence is a period of considerable development, making the adolescent brain particularly vulnerable to negative effects of alcohol and cannabis use. Developing and testing interventions that target both alcohol and cannabis use during adolescence are vital to decreasing costly consequences. Biases in cognitive processing of drug-related stimuli play an important role in the development and maintenance of problematic substance use. The Approach-Avoidance Task (AAT) is a computerized program, effective in assessing implicit approach biases for both alcohol and cannabis, in which participants push or pull a joystick in response to an irrelevant feature of an image presented on a computer screen (e.g., push when in portrait, pull when in landscape). A modified version of the AAT (mAAT) is also used as a Cognitive Bias Modification (CBM) intervention, to retrain participants’ implicit biases toward or away from stimuli by presenting the target stimuli predominantly in one format (e.g., push or pull). Despite research demonstrating the effectiveness of mAAT interventions to reduce problematic alcohol and cannabis use, there is a dearth of research examining this intervention among adolescents. The proposed research will test a pilot randomized controlled trial of an integrated mAAT intervention to target co-occurring alcohol and cannabis use among treatment-seeking adolescents (N=52). Specific aims include to test the effect of the intervention on approach biases for cannabis/alcohol stimuli (Aim 1) and cannabis/alcohol use at 1- and 3-months post-intervention (Aim 2), and to examine the role of intentions and cravings as mediators in the relationship between treatment condition and use. The research environment, facilities, and resources at MUSC are ideally suited for mentored career development in addiction research. K23 training objectives are to: 1) increase knowledge of etiological and treatment mechanisms for cannabis use; 2) acquire essential knowledge and experience across the stages of clinical trial research among treatment-seeking adolescents with substance use problems, including incorporating EMA methods; 3) develop expertise in CBM; 4) gain experience incorporating EEG to identify change mechanisms in substance use interventions; and 5) enhance scientific communication and overall academic productivity. Structured mentorship from Drs. Carla Kmett Danielson, Lindsay Squeglia, Lisa McTeague, and Robert Miranda Jr. will ensure training goals are met. The candidate’s long-term career goal Is to direct a research portfolio that: 1) develops and tests innovative intervention approaches for substance use problems among adolescents and emerging adults; 2) delivers these innovative interventions in existing real-world settings; and 3) identifies change mechanisms within interventions using multiple units of analysis. The training proposed herein is designed to develop expertise across these areas, represents a clear progression from prior training and would not be possible without this K23.

项目摘要/摘要 酒精和大麻是青少年中的第一和第二常用物质。 青春期是一个相当大的发展时期，使青少年大脑特别容易受到影响。 酒精和大麻的负面影响。 使用大麻对于降低昂贵昂贵的昂贵认知处理至关重要 与药物有关的刺激的刺激在有问题的物质使用的发展和维持中起着重要作用。 避免接近的任务（AAT）是计算机化程序，有效评估隐式方法偏见 对于酒精和大麻，参与者在其中推动或拉动操纵杆，以响应不可避免的功能 在计算机屏幕上呈现的图像（例如，在肖像中推动，在景观中拉动） AAT（MAAT）的版本也被用作认知偏置修饰（CBM）干预措施 参与者的IIPLICIT偏见或远离长期刺激的偏见。 格式（例如，推或拉）。 有问题的酒精和大麻使用，缺乏研究，研究了这一点 青少年。 在治疗的青少年中，靶向靶向同时发生的酒精和大麻使用（n = 52）。 具体目的包括测试间隔对大麻/酒精刺激的方法偏见的影响（AIM 1）和大麻/酒精在国际境内1和3个月（AIM 2），并检查强度的作用 渴望作为治疗条件与使用之间关系的介体。 MUSC的设施和资源非常适合成瘾研究中的职业发展 培训目标是：1）增加对大麻使用的病因和治疗机制的知识； 在临床试验试验试验试验试验cleatmeng治疗搜索的整个阶段获得基本知识和经验 具有物质使用问题的青少年，不融入EMA方法； 3）在CBM中发展专业知识； 4）获得结合脑电图以识别物质使用干预措施中的变化机制的经验； 提高科学沟通和总体学术生产力。 Kmett Danielson，Lindsay Squeglia，Lisa McTeague和Robert Miranda Jr.将确保实现训练目标。 候选人的长期职业目标是指导一个研究组合：1）开发和测试创新的 青少年和新兴成年人中使用物质使用问题的方法； 在熄灭现实世界中的创新干预措施； 使用多个分析单位。 区域，压抑者从先前的培训中明显进展，没有这个K23是不可能的。