Exercise, MANF, and Chemical-Induced Neurodegeneration

运动、MANF 和化学物质引起的神经变性

• 批准号: 10380263
• 负责人: Jessica Helene Hartman
• 金额: $ 2.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-09 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380263
• 关键词: Acute; Animals; Automobile Driving; Chemicals; Development; Environment; Exercise; Exposure to; Future; Goals; Laboratories; Mentors; Minority; Mitochondria; Nerve Degeneration; Oxidative Stress; Oxidopamine; Physicians; Production; Reagent; Research; Research Personnel; Research Training; Rotenone; Scientist; Testing; Toxic effect; Training; career; career development; conditioning; design; dopaminergic neuron; experimental study; innovation; neurotoxicity; novel; parent grant

SUMMARY The main goal of this research training plan for Ms. Jasmin Johnson's academic and scientific development is to define the underlying mechanisms driving exercise protection from rotenone-induced neurodegeneration and exacerbation of 6-hydroxydopamine-induced neurodegeneration. This research goal is related to the expansion of studies proposed in Specific Aim 3 of the parent grant. This proposal is designed to the test the novel hypothesis that increased baseline ROS from long-term exercise conditioning sensitizes dopamine neurons to the acute oxidative challenge with 6-hydroxydopamine, while providing protection from mitochondrial inhibition by rotenone. In addition to a robust and rigorous research training plan involving innovative new reagents, there is a strong mentoring plan that supports Ms. Jasmin Johnson's future career plans in a strong scientific and academic environment within the PI's laboratory and supported by the Co- Mentor. This supplemental application will provide increased diversity of development of a minority researcher as a biomedical clinician scientist.

概括 Jasmin Johnson女士学术和科学发展的研究培训计划的主要目标是 确定运动保护免受鱼藤酮诱导的神经变性的潜在机制 6-羟基多巴胺诱导的神经变性加剧。该研究目标与 扩大母基金具体目标 3 中提出的研究范围。该提案旨在测试 新的假设表明，长期运动调节增加基线 ROS 会使多巴胺敏感 神经元应对 6-羟基多巴胺的急性氧化挑战，同时提供保护 鱼藤酮抑制线粒体。除了强大而严格的研究培训计划外，还涉及 创新的新试剂，有强有力的导师计划支持Jasmin Johnson女士未来的职业生涯 在 PI 实验室内强大的科学和学术环境中制定计划，并得到 Co- 导师。该补充申请将为少数族裔研究人员提供更多的发展多样性 作为一名生物医学临床科学家。