Administrative Core

行政核心

• 批准号: 10376628
• 负责人: GEORGE A KUCHEL
• 金额: $ 44.98万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376628
• 关键词: Administrative; Core

The Administrative Core will coordinate and oversee all research activities across KAPP-Sen TMC Collaborative sites in support of SenNet goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas, and placenta. Efforts will be made to ensure ongoing robust and productive dialogue and input from KAPP-Sen TMC investigators and staff with varied relevant areas of scientific expertise, disciplinary backgrounds, and perspectives. Moreover, continued innovation will be pursued by leveraging the ability of investigators from across SenNet to provide unique cutting-edge novel insights arising from their individual disciplines. The Core will also participate in ongoing program evaluation using both informal strategies and the established capacities of the UConn Center on Aging Evaluation and Population Assessment Research Core to perform rigorous program evaluation throughout KAPP-Sen and of Sen-Net partners as a means of ensuring the achievement of our objectives and pre-defined metrics, thus enabling optimal allocation of resources. Core leadership and staff will also collaborate with NIH staff and other SenNet leaders in ensuring the successful implementation of an innovative Phased Adaptive Approach to study design and data analysis, thereby providing a rational path from an Initial Data Generation Phase to an Interim Evaluation and Recalibration Phase leading ultimately to the Study Full Scale-Up and Completion Phase.

行政核心将协调和监督Kapp-Sen TMC的所有研究活动 协作站点支持Sennet目标，以绘制细胞衰老及其相关 健康的人类肾脏，脂肪组织，胰腺和胎盘中的分泌表型。努力将是 为了确保Kapp-Sen TMC调查人员和员工的持续强大而富有成效的对话和投入 具有科学专业知识，纪律背景和观点的相关领域。而且， 通过利用来自Sennet的调查人员提供的能力，将继续进行创新 独特的尖端小说洞察力是由他们的个体学科产生的。 核心还将使用非正式策略和既定的策略参加正在进行的计划评估 UConn老龄化评估和人口评估研究核心的能力 整个Kapp-Sen和Sen-Net合作伙伴的严格计划评估是确保 实现我们的目标和预定义的指标，从而实现了资源的最佳分配。 核心领导和员工还将与NIH的员工和其他Sennet领导人合作，以确保 成功实施创新的分阶段自适应方法来研究设计和数据分析， 从初始数据生成阶段到临时评估和 重新校准阶段最终导致研究完整扩大和完成阶段。