Chemical Gating of a Tube-in-a-Tube Semiconductor

管中管半导体的化学门控

基本信息

批准号：
9333419
负责人：
YuHuang Wang
金额：
$ 29.48万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9333419
关键词：
AFP gene Age Antibodies Area Binding Biological Biological Markers Biosensor Cancer Detection Cancer Model Carbon Cessation of life Charge Chemicals Chemistry Clinical Complementary DNA DNA Data Detection Developing Countries Development Devices Diagnostic Diagnostic Procedure Disease Early Diagnosis Early treatment Electrodes Enzyme-Linked Immunosorbent Assay Excision Exhibits Fetoprotein Film Foundations Label Lasers Light Malignant Neoplasms Measurement Medical Medical Technology Modeling Nanostructures Nature Paper Printing Prostate-Specific Antigen Proteins Research Resources Semiconductors Series Specificity Structure Surface Technology Thick Thinness Time Transistors Tube Variant Work World Health Organization Writing alpha-Fetoproteins base cancer biomarkers cancer therapy clinically relevant cost cost effective density functional group lithography molecular scale multiplex detection nanofabrication point of care public health relevance receptor density sensor single walled carbon nanotube targeted biomarker voltage water flow

项目摘要

DESCRIPTION (provided by applicant): There were over 8 million cancer-related deaths worldwide in 2013. According to the World Health Organization, this death toll will reach 13.1 million by 2030 unless rapid and cost- effective diagnostic technologies are developed for the early detection of the disease. Current diagnostic techniques such as ELISA are time-consuming for point-of-care settings and often cost-prohibitive for developing countries where resources are scarce. Here, we propose a potentially transformative all-carbon electronic biosensor based on a tube-in-a-tube semiconductor (Tube^2) created by our research team. A Tube^2 is composed of an atom-thick semiconductor nested within a charged, covalent functional shell. We hypothesize that conductance through the semiconductor can be completely controlled solely by surface functional groups on the shell such that binding of a small number of targeted cancer markers can be detected electrically. Our preliminary studies have shown evidence of chemically gated field effect detection of DNA using thin-film Tube^2 sensors. The proposed research will focus on three specific aims: 1) establishing the fundamentals of electrode-free chemical gating of Tube^2; 2) coaxial chemical lithography with light; and 3) label-free and multiplexed detection of cancer biomarkers by Tube^2 sensors. In Aim 1, a series of aryl functional groups will be attached covalently at controlled densities on Tube^2 to quantitatively determine the gating effects of surface functional groups. In Aim 2, we will investigate light-driven defunctionalization and re-functionalization of Tube^2 as the basis for a straightforward, fundamentally new fabrication approach to electronic sensor arrays. In Aim 3, chemically gated field effect detection of model cancer markers, including prostate-specific antigen and ¿-fetoprotein, will be investigated in thin-film Tube^2 sensor arrays. This work may provide a new foundation for the development of rapid and cost-effective medical diagnostic technologies.

描述（通过应用程序证明）：除非开发出快速且具有成本效益的诊断技术，否则在2013年在全球范围超过800万次与癌症相关的死亡资源很少。我们提出了一个潜在的变换的全碳电子，该电子胶是在我们的研究团队中产生的管子中的tube-in-a-a-tube半导体（管^2）。壳上的表面官能团仅通过薄膜管^2传感器对DNA的化学门控效应检测。 3）在AIM 1中，无标记和多路复用的检测，在AIM 1中，一系列的芳基官能团将在管子上的受控密度^2附加，以确定门控f表面官能团2，我们将研究管道^2 2的光驱动的解剖和重新函数化，作为对电子传感器阵列的构造方法的基础。 - 蛋白质将在薄膜管^2传感器阵列中进行研究。