Characterizing cognition across the lifespan in untreated psychosis in China

描述中国未经治疗的精神病患者整个生命周期的认知特征

• 批准号: 9403816
• 负责人: MATCHERI S. KESHAVAN
• 金额: $ 60.26万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9403816
• 关键词: Address; Age; Antipsychotic Agents; Attenuated; Bipolar Disorder; Brain; China; Clinical; Clinical Psychology; Cognition; Cognitive deficits; Collaborations; Communities; Country; Cross-Sectional Studies; Diagnostic; Educational workshop; Epidemiology; Ethics; Gender; Goals; Grant; Income; Individual; Interdisciplinary Study; Intervention; Life Cycle Stages; Locales; Longevity; Longitudinal Studies; Measures; Mental Health Services; Modeling; Patients; Pattern; Persons; Pharmaceutical Preparations; Population; Procedures; Province; Psychiatric epidemiology; Psychiatry; Psychotic Disorders; Recording of previous events; Recruitment Activity; Research; Research Domain Criteria; Research Infrastructure; Research Personnel; Research Training; Role; Sampling; Schizoaffective Disorders; Schizophrenia; Severities; Symptoms; Testing; Training; Training Programs; Verbal Learning; age related; career; cohort; comparison group; executive function; experience; follow-up; insight; processing speed; programs; public health relevance; response; scale up; severe mental illness; treatment program; young adult

 DESCRIPTION (provided by applicant): We propose to take advantage of a unique opportunity to study cognition and its relation to other domains in a large untreated sample of individuals with psychosis (IWP), within an ethically appropriate context that is unlikely to continue to be available. After the onset of psychosis, studies of cognition in treated IWP suggest persisting deficits in many SCZ patients; these are present in bipolar affective psychoses to a somewhat lesser extent, indicating a continuum of severity in psychosis. To address this, we propose to study cognition among a large sample (n=500) of completely untreated IWP, assessed prior to AP treatment, within Ningxia Province who span a wide age range (21 to 65) and are community sampled. Ningxia is among the most poor and remote provinces in China, where the 686 Program has not fully penetrated but where identification of untreated cases is increasing. A community sampled comparison group of treated IWP's (n=500) (matched on locale, gender, age, and duration of illness) will also be recruited. Our goal is to illuminate the natural course of cognition and its relation to symptoms and functioning, in the absence of medication effects. We possess an unprecedented opportunity to do so within the 686 national treatment program. Our multidisciplinary research team is comprised of world-recognized experts from the fields of epidemiology, clinical psychology, and psychiatry. Building upon a history of successful collaborations, each investigator brings extensive capacity-building experience to execute this challenging project. A major goal is also to train a new cohort of investigators in Ningxia Province to increase capacity to intervene with untreated psychosis, thus serving as a model for scale-up for the 686 program.

 描述（由申请人提供）：我们建议利用一个独特的机会，在一个不太可能继续存在的伦理上适当的背景下，在大量未经治疗的精神病个体（IWP）样本中研究认知及其与其他领域的关系。精神病发作后，对接受治疗的 IWP 的认知研究表明，许多 SCZ 患者存在持续的认知缺陷；这些缺陷在双相情感性精神病中存在，程度稍轻，表明其严重程度是连续的。为了解决这个问题，我们建议对宁夏省内一个大样本（n = 500）完全未经治疗的 IWP 进行认知研究，这些人在 AP 治疗之前进行评估，这些人的年龄范围很广（21 至 65 岁），并且是社区抽样。宁夏是中国最贫困、最偏远的省份之一，686 计划尚未完全渗透到该地区，但未经治疗的病例数量正在增加。 （n=500）（根据地点、性别、年龄和疾病持续时间进行匹配）我们的目标是阐明在没有药物作用的情况下认知的自然过程及其与症状和功能的关系。在 686 国家治疗计划中，我们拥有前所未有的机会，我们的多学科研究团队由来自流行病学、临床心理学和精神病学领域的世界知名专家组成，每个研究人员都拥有丰富的合作经验。执行这一具有挑战性的项目的能力建设经验也是一个主要目标，是在宁夏省培训一批新的研究人员，以提高干预未经治疗的精神病的能力，从而成为扩大 686 项目的典范。