Integration of Mixtures Toxicology, Toxicogenomics and Statistics.

混合物毒理学、毒理学和统计学的整合。

• 批准号: 9539399
• 负责人: David Charles Wheeler
• 金额: --
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9539399
• 关键词: Toxicogenomics; Toxicology; statistics

DESCRIPTION (provided by applicant): The objective of this training grant is to train biostatisticians to work in inter-disciplinary collaborative teams addressing the problems associated with evaluating the effects of relevant environmental chemical mixtures or in the area of toxicogenomics. A key to the success of this venture is the joining of the efforts of key scientists (genomic or mixtures toxicologists, environmental epidemiologists and biostatisticians) in the fields of chemical mixtures or toxicogenomics with trainees from a department of biostatistics. The goal is for trainees to gain an understanding of and experience working on statistical issues for these two important areas of toxicology. These trainees will be qualified to hold unique positions in governmental agencies, academia, and industry where properly evaluating risks associated with relevant chemical exposures is becoming increasingly important. The trainees will be Ph.D. students in the Department of Biostatistics at the Virginia Commonwealth University (VCU), where they will pursue pre-doctoral training in the discipline of biostatistics. Additional expertise will be achieved through work on dissertation/research topics that are pertinent to the field of mixtures or toxicogenomics and through collaborative work with toxicologists and/or environmental epidemiologists actively working in their area of interest. Through these research projects, students will gain experience collaborating with a team of experts working to understand the relationship between environmental exposures and human disease susceptibility. The trainees will assist in the design of studies, conduct appropriate power analyses, analyze resulting data, write reports with proper interpretation of the results, and participate in a collaborative team to produce one or more manuscripts for peer-review publication. In addition, the trainees will have dissertation topics developing statistical methodology for issues involved in the design and analysis of data resulting from chemical mixtures studies or high-throughput technologies.

描述（由申请人提供）：这项培训补助金的目的是培训生物统计学家，以研究与评估相关环境化学混合物或毒物基因组学领域的影响相关的问题的跨学科合作团队。这项事业成功的关键是关键科学家（基因组或混合物毒理学家，环境流行病学家和生物统计学家）在化学混合物或毒理基因组学领域与来自生物统计学系的受训者的努力。目的是让学员了解这两个重要领域的统计问题的理解和经验。这些学员将有资格 在政府机构，学术界和行业中担任独特的立场，在该机构中适当评估与相关化学暴露相关的风险变得越来越重要。学员将是博士学位。弗吉尼亚联邦大学（VCU）生物统计学系的学生将在生物统计学学科中进行博士前培训。通过与混合或毒理学学领域以及与毒理学家和/或环境流行病学家的合作工作，将通过在论文/研究主题上进行研究来实现其他专业知识。通过这些研究项目，学生将获得与一群专家团队合作，以了解环境暴露与人类疾病易感性之间的关系。学员将协助设计研究，进行适当的功能分析，分析结果数据，对结果进行适当解释，并参与一个协作团队，以制作一个或多个手稿，以供同行评审出版。此外，学员将有论文主题开发统计方法论，以针对化学混合物研究或高通量技术引起的数据设计和分析。