PREDICTOR OF ADVANCED SUB-CLINICAL ATHEROSCLEROSIS

晚期亚临床动脉粥样硬化的预测因子

• 批准号: 7607490
• 负责人: PAMELA OUYANG
• 金额: $ 0.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607490
• 关键词: Age; Algorithms; Atherosclerosis; Blood Vessels; Cardiac; Cholesterol; Clinical; Computer Retrieval of Information on Scientific Projects Database; Deposition; Development; Diagnosis; Disease; Education; Funding; Grant; Inflammatory; Institution; Invasive; Measures; Methods; Multicenter Studies; Population Study; Prevention; Research; Research Personnel; Resources; Risk; Risk Estimate; Risk Factors; Score; Sensitivity and Specificity; Skin; Skin Tissue; Source; Stratification; Stress Tests; Tissues; Uncertainty; United States National Institutes of Health; Weight; base; disorder risk; improved; novel; predictive modeling; programs; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple risk factors contribute to the development of atherosclerosis. The National Cholesterol Education Program provides guidleines for the prevention, diagnosis and management of coroanry aretery disease (CAD) based on the Framingham risk score (FRS), an algorithm that assigns weights to the major CAD risk factors . Uncertainties of the current predictive models, including FRS have been established and have prompted a search for new strategies to improve upon risk stratification. Several methods have been used to measure the presence of atherosclerosis in study populations and to track the progression of subclinical disease. Many have high specificity and sensitivity but are invasive and/or costly. Cholesterol is deposited in tissues other than the vasculature including skin. It is the major constituent of skin and comprises 11%, by weight, of total body content of choleseterol. Skin tissue cholesterol (SC) has been suggested to reflect vascular changes associated with age and atheroslcerosis. Recently SC levels have been shown to be significantly associated with positive treadmill stress tests and angiographic CAD. Additional studies have shown a relationship between SC and circulating inflammatory markers and subclinical atherosclerosis. In addition SC is associated with increased carotid IMT even after adjusting for age, sex and other cardiac risk factors. SC was associated with increased carotied IMT after adjustent for Framingham risk score. This multicenter study will determine the correlation between skin cholesterol and carotid IMT in 600 asymptomatic subjects selected as being low, intermediate and high risk by FRS risk estimate. Skin cholesterol will also be compared to established and novel markers of CAD risk.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 多种危险因素导致动脉粥样硬化的发生。国家胆固醇教育计划根据弗雷明汉风险评分 (FRS)（一种为主要 CAD 风险因素分配权重的算法）为冠状动脉疾病 (CAD) 的预防、诊断和管理提供指南。当前预测模型（包括 FRS）的不确定性已经建立，并促使人们寻找新的策略来改进风险分层。已使用多种方法来测量研究人群中动脉粥样硬化的存在并追踪亚临床疾病的进展。许多具有高特异性和敏感性，但具有侵入性和/或昂贵。 胆固醇沉积在血管系统以外的组织中，包括皮肤。它是皮肤的主要成分，胆固醇含量占全身重量的 11%。皮肤组织胆固醇（SC）被认为可以反映与年龄和动脉粥样硬化相关的血管变化。最近，SC 水平已被证明与跑步机压力测试和血管造影 CAD 呈阳性显着相关。其他研究表明 SC 和循环炎症标志物与亚临床动脉粥样硬化之间存在关系。 此外，即使在调整了年龄、性别和其他心脏危险因素后，SC 仍与颈动脉 IMT 增加相关。调整弗雷明汉风险评分后，SC 与颈动脉 IMT 增加相关。这项多中心研究将确定 600 名无症状受试者的皮肤胆固醇和颈动脉 IMT 之间的相关性，这些受试者通过 FRS 风险评估被选为低、中和高风险。皮肤胆固醇还将与已知的和新的 CAD 风险标志物进行比较。