NEUROPSYCHOLOGICAL DYSFUNCTION/NEUROIMAGING ABNORMALITIES IN ADULTS WITH SCD

患有 SCD 的成人的神经心理功能障碍/神经影像异常

• 批准号: 7607781
• 负责人: Lori E Crosby
• 金额: $ 1万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607781
• 关键词: Adult; Age; Attention; Brain Injuries; Caring; Chronic; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Enrollment; Event; Functional disorder; Funding; Grant; Image; Institution; Intervention Trial; Investigation; Link; Magnetic Resonance Imaging; Memory; Neurocognitive; Patients; Purpose; Randomized; Research; Research Personnel; Resources; Score; Sickle Cell Anemia; Source; Standards of Weights and Measures; Stroke; Transfusion; Treatment Protocols; United States National Institutes of Health; design; experience; neuroimaging; neuropsychological; peer; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine the extent of memory and attention problems in adults with sickle cell disease. Neurologically intact adult patient's ages 21-55 years will be enrolled. That is adults who have not experienced a stroke or other brain damage. The study will also evaluate the link between these events or conditions and abnormal MRI. These findings will be compared to healthy people with similar backgrounds. The primary objective is to determine the extent of neurocognitive dysfunction in neurologically asymptomatic adult patients with sickle cell disease. The secondary objective to determine the association between neurocognitive dysfunction and imaging abnormalities. This is a cross-sectional investigation trial designed to compare neuropsychological function of adult neurologically normal Hb SS/SBo patients with matched-peer controls. A pilot intervention trial will randomize a subset of patients from the primary study to undergo either a chronic transfusion regimen or receive standard care alone, for six months. A subset of these subjects with WAIS III PIQ score greater than one standard deviation from the normative data (85) will be eligible for randomization in the pilot transfusion trial.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是确定患有镰状细胞病的成年人的记忆和注意力问题的程度。将招募年龄在 21-55 岁、神经系统完好的成年患者。这是指没有经历过中风或其他脑损伤的成年人。该研究还将评估这些事件或状况与异常 MRI 之间的联系。这些发现将与具有相似背景的健康人进行比较。 主要目的是确定无神经症状的镰状细胞病成年患者神经认知功能障碍的程度。次要目标是确定神经认知功能障碍和影像学异常之间的关联。 这是一项横断面研究试验，旨在比较成人神经功能正常 Hb SS/SBo 患者与匹配的同伴对照的神经心理功能。试点干预试验将从主要研究中随机抽取一部分患者，接受为期六个月的长期输血方案或单独接受标准护理。 WAIS III PIQ 评分与规范数据 (85) 相比大于一个标准差的受试者子集将有资格在试点输血试验中进行随机分组。