CV RISK FACTORS/VASCULAR FUNCTION

心血管风险因素/血管功能

基本信息

批准号：
7607793
负责人：
Elaine Mott Urbina
金额：
$ 2.51万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-15 至 2007-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7607793
关键词：
Adult Autopsy Blood Pressure Blood Vessels Calcium Cardiac Carotid Arteries Case-Control Studies Cephalic Child Childhood Computer Retrieval of Information on Scientific Projects Database Condition Data Databases Dental Diabetes Mellitus Disease Dyslipidemias Early Intervention Event Family history of Fasting Fibrinogen Functional disorder Funding Future Generalized Atherosclerosis Glucose Grant Head High Prevalence Homocysteine Homocystine Individual Inflammation Institution Insulin Laboratories Leg Lesion Lipids Medial Outcome Pediatric Radiologist Peripheral Phosphorus Physiologic pulse Pulse taking Research Research Personnel Resources Risk Risk Factors Roentgen Rays Scanning Site Source Stenosis Stroke Temporal bone structure Testing Thick Ultrasonography United States National Institutes of Health Upper arm Vascular calcification X-Ray Computed Tomography brachial artery calcification calcium phosphate case control cysteine rich protein demographics indexing prevent radiologist theories

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Calcifications of the intra-cranial carotid arteries (ICA) are frequently found in adults on routine head CT scans. They correlate strongly with CV risk factors & are associated with angiographic vessel stenosis supporting the idea that vascular calcifications are a marker for generalized atherosclerosis. Even simple dental X-rays may identify calcifications which relate to abnormal carotid ultrasound & predict subsequent vascular events. The significance of ICA calcifications in children is not known eve though radiologist frequently recognize them on head CT scans and one small pediatric autopsy study found a high prevalence of such lesions. These data led us to hypothesize that ICA calcifications in children represent early atherosclerotic change. We will test this theory by performing a case-control study selecting subjects from an existing database of children who underwent a temporal bone CT scan. These scans collected over 2 years, were evaluated by Pediatric Radiologist for presence of ICA calcification. Of 408 children, 27% had calcification although only 1 had a medial condition that might explain the findings (diabetes and dyslipidemia). Fifty cases & fifty controls will be studies with 1/2 of the subject younger (6 to 12 years) and 1/2 older (12 to 19 years) for a total of 100. Demographics, medical and family history, anthropometrics & blood pressure data will be collected. Laboratory analyses will include calcium, phosphorus, glucose & insulin levels, fasting lipid panel, high sensitivity CRP, homocysteine & fibrinogen. Central & peripheral vascular sites tested will include carotid intimate-media thickness & compliance, aortic augmentations index, brachial artery distensibility & pulse wave velocity to the arm, trunk & leg. Analyses will be performed to determine if children with ICA calcification 1) demonstrate other abnormalities in vascular function; 2) have abnormal levels of CV risk factors; and 3) whether vascular abnormalities correlate with levels of CV risk factors. Potential mechanisms underlying early vascular calcifications and dysfunction will also be explored by comparing calcium-phosphate product, levels of systemic inflammation, fibrinogen and homocysteine between cases & controls. The proposed research will allow us to determine the importance of vascular calcification as a marker for early atherosclerotic disease in children allowing earlier intervention in high risk individuals to prevent future adverse cardiac and stroke-related outcomes.

该子项目是利用该技术的众多研究子项目之一资源由 NIH/NCRR 资助的中心拨款提供。子项目及研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金，因此可以在其他 CRISP 条目中表示。列出的机构是中心，不一定是研究者的机构。成人常规头部 CT 扫描经常发现颅内颈动脉 (ICA) 钙化。它们与心血管危险因素密切相关，并与血管造影血管狭窄相关，支持血管钙化是全身动脉粥样硬化的标志这一观点。即使是简单的牙科 X 射线也可以识别与异常颈动脉超声相关的钙化并预测随后的血管事件。尽管放射科医生经常在头部 CT 扫描中识别出 ICA 钙化，并且一项小型儿科尸检研究发现此类病变的患病率很高，但儿童 ICA 钙化的重要性尚不清楚。这些数据使我们推测儿童 ICA 钙化代表早期动脉粥样硬化变化。我们将通过一项病例对照研究来检验这一理论，该研究从接受过颞骨 CT 扫描的现有儿童数据库中选择受试者。这些扫描收集了 2 年多的时间，由儿科放射科医生评估 ICA 钙化的存在。在 408 名儿童中，27% 患有钙化，尽管只有 1 名儿童患有可以解释这一结果的身体状况（糖尿病和血脂异常）。将研究 50 个病例和 50 个对照，其中 1/2 的受试者年龄较小（6 至 12 岁），1/2 的受试者年龄较大（12 至 19 岁），总共 100 名受试者。人口统计、医疗和家族史、人体测量学和血压将收集数据。实验室分析包括钙、磷、葡萄糖和胰岛素水平、空腹血脂、高敏感性 CRP、同型半胱氨酸和纤维蛋白原。测试的中枢和外周血管部位将包括颈动脉内膜厚度和顺应性、主动脉增强指数、肱动脉扩张性和手臂、躯干和腿部的脉搏波速度。将进行分析以确定患有 ICA 钙化的儿童是否 1) 表现出其他血管功能异常； 2) 心血管危险因素水平异常； 3) 血管异常是否与心血管危险因素水平相关。还将通过比较病例与对照之间的磷酸钙产物、全身炎症、纤维蛋白原和同型半胱氨酸水平来探索早期血管钙化和功能障碍的潜在机制。拟议的研究将使我们能够确定血管钙化作为儿童早期动脉粥样硬化疾病标志物的重要性，从而能够对高危个体进行早期干预，以防止未来出现与心脏和中风相关的不良后果。