Collaborative Observational Study of Myopia in COMET Children 2: Clinial Ceneter

COMET 儿童近视协作观察研究 2：临床中心

• 批准号: 7315361
• 负责人: WENDY L MARSH-TOOTLE
• 金额: $ 24.15万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7315361
• 关键词: 11 year old; 16 year old; 17 year old; Address; Adolescent; Adult; African American; Age; Alabama; Blindness; Child; Clinical; Cohort Studies; Contact Lenses; Cornea; Data; Development; Enrollment; Environmental Risk Factor; Esophoria; Ethnic Origin; Ethnic group; Eye; Future; Gender; Glass; Growth; High Prevalence; Hispanics; Hour; Individual; Intervention; Learning; Literature; Measurement; Modeling; Myopia; Observational Study; Occupational; Operative Surgical Procedures; Parents; Participant; Pathology; Physiologic Intraocular Pressure; Population; Predictive Factor; Protocols documentation; Public Health; Refractive Errors; Risk; Risk Factors; Subgroup; Testing; Thick; Time; Universities; Vision; Work; base; cohort; ethnic difference; follow-up; high intraocular pressure; macula; predictive modeling; response

DESCRIPTION (provided by applicant): This proposal is for the University of Alabama at Birmingham Clinical Center to continue to annually examine the 127 currently enrolled COSMICC participants (only 5 subjects are lost to follow-up since enrollment in 1997-98) for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.

描述（由申请人提供）：该提案是针对伯明翰临床中心的阿拉巴马大学继续检查目前注册的COSMICC参与者的127名（自1997 - 98年入学以来，只有5名受试者丢失了5名受试者）进行了5年的额外5年（COSMICC2协议总计，14年）。 The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2）测试4个与环境风险因素有关的假设，用于近视的进展，稳定和轴向伸长率，在这种良好的近视群体中； 3）测试与COSMICC受试者IOP，CCT和黄斑厚度与近视相关的变化发展的三个假设。近视的高度患病率（占美国成年人口的25％）及其作为公共卫生问题（可能导致视力丧失和失明的危险因素）的突出率强调了对在未来进步和最终稳定的机制增强理解的重要性，因此，在将来，近视可能限于低水平。更好地了解近视进展和稳定的因素也将有助于指导干预措施的选择和时机，并针对那些可能受益于治疗最大的群体。