LIPEMIA: CARBOHYDRATE AND GLYCERIDE METABOLISM

脂血症：碳水化合物和甘油酯代谢

• 批准号: 7605156
• 负责人: GERALD M. REAVEN
• 金额: $ 7.37万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605156
• 关键词: American; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Consensus; Coronary Arteriosclerosis; Defect; Diet; Eating; Fatty acid glycerol esters; Funding; Glucose; Glucose Plasma Concentration; Glycerides; Grant; High Density Lipoprotein Cholesterol; Hypertension; Individual; Ingestion; Institution; Insulin; Lead; Low-Density Lipoproteins; Metabolic; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Patients; Pharmacotherapy; Plasma; Research; Research Personnel; Resources; Risk; Source; Triglycerides; United States National Institutes of Health; density; falls; hypertension treatment; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NIH has recently distributed the results of a consensus conference, which urges that "all Americans" consume low fat-high carbohydrate diets. Previous results from our research group have demonstrated that the ingestion of low fat-high carbohydrate diets by normal individuals or patients with non-insulin-dependent diabetes can lead to an increase in plasma concentrations of glucose, insulin, triglyceride (TG), as well as a fall in both plasma high density and low density lipoprotein (LDL) concentrations. Since the risk of developing coronary artery disease (CAD) has been shown to be associated with all of these metabolic changes, questions can be raised as to the appropriateness of the advice that "all Americans" eat low fat/high carbohydrate diets. Recent observations have shown that patients with untreated hypertension have higher than normal plasma glucose, insulin and TG concentrations. Institution of several forms of anti-hypersensitive drug therapies have been shown to accentuate these metabolic defects as well as lower plasma HDL-cholesterol concentration. Indeed, the presence of these metabolic abnormalities may explain why treatment of hypertension has not reduced the risk of coronary artery disease. Given the presence of the metabolic defects outlined above, and the fact that these same changes are aggravated by low fat/high carbohydrate diets, it is necessary to raise the possibility that the recommended dietary change may increase, not decrease, the risk of CAD in patients with hypertension.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 美国国立卫生研究院最近发布了一次共识会议的结果，敦促“所有美国人”食用低脂肪高碳水化合物的饮食。 我们研究小组之前的研究结果表明，正常人或非胰岛素依赖型糖尿病患者摄入低脂高碳水化合物饮食会导致血浆葡萄糖、胰岛素、甘油三酯 (TG) 浓度升高血浆高密度脂蛋白和低密度脂蛋白（LDL）浓度均下降。 由于罹患冠状动脉疾病 (CAD) 的风险已被证明与所有这些代谢变化有关，因此人们可能会质疑“所有美国人”都吃低脂肪/高碳水化合物饮食的建议是否合适。 最近的观察表明，未经治疗的高血压患者的血浆葡萄糖、胰岛素和TG浓度高于正常人。 多种形式的抗过敏药物疗法已被证明会加剧这些代谢缺陷并降低血浆高密度脂蛋白胆固醇浓度。 事实上，这些代谢异常的存在可以解释为什么高血压治疗并没有降低冠状动脉疾病的风险。 鉴于上述代谢缺陷的存在，以及低脂肪/高碳水化合物饮食会加剧这些相同的变化，有必要提出以下可能性：推荐的饮食改变可能会增加而不是降低冠心病的风险。高血压患者。