MSKCC Clinical Oncology Research Career Development Program

MSKCC 临床肿瘤学研究职业发展计划

基本信息

批准号：
7678564
负责人：
GARY K SCHWARTZ
金额：
$ 64.17万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-19 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7678564
关键词：
Arts Award Basic Cancer Research Basic Science Biological Cancer Biology Clinical Clinical Investigator Clinical Oncology Clinical Oncology Supplement (K12)Clinical Research Clinical Research Curriculum Award Clinical Trials Clinical Trials Design Development Discipline Doctor of Philosophy Education Educational Curriculum Environment Ethics Faculty Foundations Funding Future Goals Grant Healthcare Healthcare Systems Institution Laboratories Laboratory Research Malignant Neoplasms Medical Medicine Memorial Sloan-Kettering Cancer Center Mentored Clinical Scientist Development Program Mentors Methodology Molecular and Cellular Biology New York One-Step dentin bonding system Operative Surgical Procedures Pediatric Oncology Physicians Process Protocols documentation Public Health Qualifying Records Regulation Reporting Research Research Personnel Research Training Resources SECTM1 gene Schools Science Scientist Students Testing Therapeutic Therapeutic Human Experimentation Time Training Training Programs Translating Translational Research Translations Writing anticancer research base career career development clinical application data management design human disease human subject innovation insight oncology patient oriented patient oriented research post-doctoral training programs response

项目摘要

DESCRIPTION (provided by applicant): In this era of revolutionary insights into the basic scientific principles underlying human diseases, there is continuing concern that advances in biomedical sciences do not translate directly into advances in public health care. In the last decade, the clinical research environment has been challenged by multiple factors including lack of translational research in clinical trials, fragmented oversight of clinical research, funding limitations in the health care system, and a shortage of qualified investigators. Outstanding and comprehensive clinical research training of future clinical investigators with a foundation in basic sciences must be an essential component of this process. This application by Memorial Sloan- Kettering Cancer Center (MSKCC) for the Paul Calabresi Award for Clinical Oncology (K12) brings this institution one step closer to achieving this goal of providing comprehensive training in the design, conduct and ethics of state-of-the-art clinical research for highly motivated trainees (both MDs and PhDs) dedicated to academic careers. We believe this is possible because of two key developments. The first is the successful recompetition of the K30 program which forms a critical part of the clinical oncology training program at MSKCC. The second is the establishment of the Louis V. Gerstner, Jr. Graduate School of Biomedical Science which will allow the awarding of PhDs in Cancer Biology for the first time at MSKCC. This comprehensive research training environment at MSKCC now provides the opportunity to achieve the goals of the K12: the successful career development of both MDs and PhDs in clinical cancer medicine utilizing a firm foundation in laboratory research to reach out and establish clinical trials programs. Trainees eligible for this grant are defined as future investigators in patient-oriented research. The principal aim of the K12 is to provide comprehensive training in the design, conduct and ethics of state-of-the-art clinical research for highly motivated trainees dedicated to academic careers. This program will provide the trainee the ability to: 1. Perform clinical therapeutic research that develops and tests scientific hypotheses based on fundamental and clinical research findings; 2. Design and conduct hypothesis-based, clinical therapeutic protocols which prospectively evaluate both clinical and relevant biological endpoints; 3. Conduct cancer therapeutic research in a team setting in which basic and clinical scientists collaborate and interact to expedite the translation of basic research into patient-oriented therapeutic cancer research.

描述（由申请人提供）：在这个对人类疾病基本的基本科学原则的革命性见解的时代，人们一直担心生物医学科学的进步并不能直接转化为公共卫生保健的进步。在过去的十年中，临床研究环境受到了多种因素的挑战，包括缺乏临床试验中的转化研究，对临床研究的监督分散，医疗保健系统中的资金限制以及合格的研究人员的短缺。基础科学基础的未来临床研究人员对未来临床研究人员的杰出和全面的临床研究培训必须是该过程的重要组成部分。纪念斯隆·凯特林癌症中心（MSKCC）申请保罗·卡拉布雷斯（Paul Calabresi）临床肿瘤学奖（K12），使该机构更接近实现这一目标，即实现了为高度积极进取的学员（MDS和PHD）提供最先进的临床研究的全面培训，在设计，行为和伦理学方面的全面培训。我们认为，由于两个关键的发展，这是可能的。首先是成功的K30计划的重新培训，该计划构成了MSKCC临床肿瘤培训计划的关键部分。第二个是小路易斯·格斯特纳（Louis V. Gerstner，Jr。）生物医学研究生院的建立，该学院将首次在MSKCC授予癌症生物学博士学位。现在，MSKCC的这种全面的研究培训环境为实现K12的目标提供了机会：在临床癌症医学中，MDS和PHD的成功职业发展利用实验室研究中的牢固基础来触及并建立临床试验计划。有资格获得该赠款的学员被定义为以患者为导向研究的未来研究者。 K12的主要目的是为专门从事学术职业的高度积极进取的学员的设计，行为和道德方面提供全面的培训。该计划将为受训者提供： 1。进行临床治疗研究，以基于基本和临床研究结果来开发和检验科学假设； 2。设计和进行基于假设的临床治疗方案，这些方案前瞻性评估临床和相关的生物学终点； 3.在基础和临床科学家进行合作和互动以加快基础研究为患者面向患者的治疗癌症研究的团队中进行癌症治疗研究。