Stanford Career Development Program in the Genetics & Genomics of Lun Diseases

斯坦福遗传学职业发展计划

• 批准号: 7664318
• 负责人: MARK A KRASNOW
• 金额: $ 39.96万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664318
• 关键词: Affect; Arts; Back; Defect; Development; Diagnosis; Disease; Doctor of Philosophy; Educational Curriculum; Ethics; Etiology; Funding; Genes; Genetic; Genetic Models; Genomics; Human; Human Genetics; Knowledge; Lead; Lung diseases; Mentors; Mus; Mutation; NCI Scholars Program; Organism; Pathogenesis; Pathway interactions; Patients; Research; Research Personnel; Research Project Grants; Role; Sampling; Signal Pathway; Technology; Training; abstracting; career development; gene discovery; lung development; multidisciplinary; programs; research study; skills; tool

DESCRIPTION (provided by applicant): The long term objectives of this project is to develop a multidisciplinary career development program that will equip new MD and PhD investigators with the knowledge and skills to identify mutations that cause or predispose to lung diseases and to elucidate the roles of the affected genes in the etiology and pathogenesis of the diseases. This Program will emphasize the genetics and genomics of lung development, and in particular genes that encode components of signaling pathways that control important steps in the lung development program, and how defects in such genes and pathways can cause or contribute to lung disease. The program will train Scholars in state-of-the-art technologies in mouse as well as human genetics and genomics to allow them to move back and forth between a tractable model genetic organism [mouse) where they can more easily identify new components of pathways and determine their functions in ung development and disease, and the more challenging but clinically important human genetic and genomic studies. The Program has three major components. The first is a one-year core curriculum of graduate classes in genetics and genomics that will provide Scholars with the necessary background and conceptual and technical framework for research in this field. The second is a didactic research curriculum that supplements the coursework during the first year and provides practical and ethical information and training for carrying out this type of research to Scholars. The third part is a mentored research project carried out in the second and third years using a genetic or genomic approach in mouse or in human patient samples to identify or characterize genes in a signaling pathway and their roles in lung development and disease. Upon completion of the Program, Scholars will be equipped with the tools to carry out on their own genetic and genomic experiments aimed at identifying disease genes and their roles in pulmonary diseases and obtaining independent funding for such research. Relevance: This program will provide new investigators with the knowledge and skills to discover genes that cause or contribute to lung disease and thereby lead to new ways of diagnosing and potentially treating patients with those diseases. (End of Abstract)

描述（由申请人提供）：该项目的长期目标是制定一项多学科职业发展计划，该计划将为新的MD和博士学位研究人员提供知识和技能，以识别导致或易于疾病的突变，并阐明受影响基因在病因和病原体中的作用。该程序将强调肺发育的遗传学和基因组学，以及编码控制肺发育计划中重要步骤的信号传导途径组成部分的基因，以及此类基因和途径中的缺陷如何导致或导致肺部疾病。该计划将在小鼠以及人类的遗传学和基因组学方面的最先进技术培训学者，以使它们能够在可聊天的模型遗传有机体[小鼠）之间来回移动，它们可以更轻松地识别途径的新组成部分，并确定其在UNG发育和疾病中的功能，以及更具挑战性的人类遗传和临床重要的人类遗传和原子遗传学研究。该计划具有三个主要组成部分。第一个是遗传学和基因组学研究生班的一年核心课程，该课程将为学者提供该领域研究的必要背景以及概念和技术框架。第二个是一项教学研究课程，该课程在第一年内为课程提供了课程，并提供了实用和道德信息和培训，以向学者进行此类研究。第三部分是在第二和第三年内使用小鼠或人类患者样本中的遗传或基因组方法进行的指导研究项目，以识别或表征信号传导途径中的基因及其在肺发育和疾病中的作用。该计划完成后，学者将配备使用自己的遗传和基因组实验的工具，旨在鉴定疾病基因及其在肺部疾病中的作用，并为此研究获得独立的资金。相关性：该计划将为新的研究人员提供知识和技能，以发现引起或导致肺部疾病的基因，从而导致新的诊断和潜在治疗这些疾病患者的方法。 （抽象的结尾）