The role of Nectins in fusion of the midface and genesis of cleft lip and palate.

Nectins 在中面部融合以及唇裂和腭裂发生中的作用。

• 批准号: 8183076
• 负责人: Timothy Chilton Cox
• 金额: $ 10.39万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183076
• 关键词: 19q13.3; 3q13; Affect; Antibodies; Behavior; Biological Models; Cell Adhesion Molecules; Cell Maintenance; Cell physiology; Cells; Chick Embryo; Child; Chinese People; Cleaved cell; Clinical; Complex; Congenital Abnormality; Cytoplasmic Tail; Deformity; Development; Dominant-Negative Mutation; Ectodermal Dysplasia; Ectopic Expression; Embryo; Epithelial; Epithelial Cells; Epithelium; Etiology; Face; Family; Fetus; Financial cost; Future; GTP-Binding Proteins; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic Variation; Head; Healthcare Systems; Human; Immunoglobulins; Incidence; Individual; Integral Membrane Protein; Lasers; Light; Link; Lip structure; Messenger RNA; Methodology; Molecular; Morphogenesis; Mus; Mutation; Opitz syndrome; Optics; PTPN11 gene; PVRL1; Palate; Pathogenesis; Pathway interactions; Patients; Phosphoric Monoester Hydrolases; Play; Population; Predisposition; Pregnancy; Premaxillary palate; Process; Protein Isoforms; Proteins; Protocols documentation; RNA Splicing; Rehabilitation therapy; Relative (related person); Reproducibility; Research; Role; Secondary Palate; Shapes; Signal Transduction; Syndrome; Techniques; Tissues; Transfection; Transmission Electron Microscopy; Van der Woude syndrome; X-Ray Computed Tomography; cell behavior; cleft lip and palate; cohort; craniofacial; genetic technology; genome wide association study; imaging modality; immunocytochemistry; in utero; malformation; man; member; multidisciplinary; nectin; novel; orofacial; palatal fusion; psychologic; public health relevance; reconstruction; tomography; tool