Diffusion, Adoption, and Implementation of Pharmacotherapies in Alcohol Tx

酒精治疗中药物疗法的传播、采用和实施

• 批准号: 7631469
• 负责人: Amanda J Abraham
• 金额: $ 5.07万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7631469
• 关键词: Address; Administrator; Adopted; Adoption; Alcohol dependence; Alcoholism; Alcohols; Attitude; Belief; Characteristics; Classification; Clinical; Communities; Data; Data Analyses; Data Collection; Development; Diffusion; Evidence based practice; FDA approved; Funding; Funding Agency; Future; Goals; Health; Health Personnel; Health Services; Improve Access; Injectable; Interview; Knowledge; Learning; Literature; Longitudinal Studies; Mails; Medical Technology; Modeling; Monitor; Movement; Naltrexone; Pattern; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Philosophy; Private Sector; Process; Professional counselor; Questionnaires; Research; Research Personnel; Sampling; Shapes; Site; Specific qualifier value; Structure; Substance abuse problem; Suspension substance; Suspensions; System; Techniques; Technology; Technology Transfer; Telephone; Testing; Time; Training and Education; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; acamprosate; addiction; alcohol abuse therapy; base; effectiveness measure; follow-up; innovation; programs; research to practice; theories; treatment center; treatment program; trend

DESCRIPTION (provided by applicant): Despite recent advances in the development of pharmacotherapies for the treatment of alcohol dependence, the treatment community has been slow to adopt and implement these evidence-based practices. The proposed research addresses this research-to-practice gap by examining the adoption, diffusion, and implementation of the three most recent FDA approved pharmacotherapies for the treatment of alcohol dependence-naltrexone, acamprosate, and Vivitrol. The specific aims of the proposed research are threefold: (1) Describe, compare, and contrast trends in the adoption, diffusion and implementation of naltrexone, acamprosate.and Vivitrol by addiction treatment programs. (2) Identify key structural and workforce characteristics that facilitate or impede diffusion, adoption and implementation of these three pharmacotherapies over time. (3) Specify, test, and compare the "fit" of multivariate models predicting the adoption and implementation of the three pharmacotherapies. Data for the proposed research will be taken from the National Treatment Center Study (NTCS), a nationally representative, longitudinal study of 403 privatesector addiction treatment programs. Present and future NTCS data collections provide researchers the opportunity to examine the "real time" diffusion of acamprosate and Vivitrol into everyday treatment practice and to compare overall diffusion trends with naltrexone which received FDA approval in 1994. The proposed research will make significant contributions to the field of substance abuse health services by testing models of adoption and implementation as a product of both organizational and workforce level characteristics, testing for interactions between key organizational and workforce predictors, and utilizing multi-level and longitudinal data analysis techniques. The results of this research will provide important information about the organizational and workforce characteristics that shape the movement of research based medical technologies into everyday practice and provide a greater understanding of the barriers to adoption and implementation of pharmacotherapies. This information will be relevant to treatment providers, health researchers, and health policymakers as they seek to bridge the "research to practice gap" and improve access to quality treatment for persons suffering from alcoholism.

描述（由申请人提供）：尽管最近在治疗酒精依赖的药物疗法的开发方面取得了进展，但治疗界在采用和实施这些基于证据的实践方面进展缓慢。拟议的研究通过检查 FDA 最近批准的三种治疗酒精依赖的药物疗法（纳曲酮、阿坎酸和 Vivitrol）的采用、传播和实施来解决这一研究与实践之间的差距。拟议研究的具体目标有三个：（1）描述、比较和对比成瘾治疗计划中纳曲酮、阿坎酸和 Vivitrol 的采用、传播和实施趋势。 (2) 确定随着时间的推移促进或阻碍这三种药物疗法的传播、采用和实施的关键结构和劳动力特征。 (3) 指定、测试和比较预测三种药物疗法的采用和实施的多变量模型的“拟合度”。拟议研究的数据将取自国家治疗中心研究 (NTCS)，这是一项针对 403 个私营部门成瘾治疗项目的全国代表性纵向研究。当前和未来的 NTCS 数据收集为研究人员提供了检查阿坎酸和 Vivitrol 在日常治疗实践中“实时”扩散的机会，并将总体扩散趋势与 1994 年获得 FDA 批准的纳曲酮进行比较。拟议的研究将为通过测试作为组织和劳动力层面特征的产物的采用和实施模型，测试关键组织和劳动力预测因素之间的相互作用，并利用多层次和纵向数据分析技术，在药物滥用卫生服务领域进行研究。这项研究的结果将提供有关组织和劳动力特征的重要信息，这些特征将基于研究的医疗技术转化为日常实践，并提供对采用和实施药物疗法的障碍的更深入的了解。这些信息将与治疗提供者、卫生研究人员和卫生政策制定者相关，因为他们寻求弥合“研究与实践之间的差距”并改善酗酒者获得优质治疗的机会。

项目成果

State policy influence on the early diffusion of buprenorphine in community treatment programs.

国家政策对丁丙诺啡在社区治疗项目中早期扩散的影响。

• 发表时间: 2008-06-20
• 作者: Ducharme, Lori J.;Abraham, Amanda J.
• 通讯作者: Abraham, Amanda J.