Reducing Sexual HIV Risk among Methamphetamine-Using MSM in San Diego, CA

降低加利福尼亚州圣地亚哥使用甲基苯丙胺的 MSM 的性 HIV 风险

• 批准号: 7223039
• 负责人: Richard S Garfein
• 金额: $ 21.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7223039
• 关键词: AIDS education /prevention; African American; Hispanic Americans; behavioral /social science research tag; clinical research; counseling; health services research tag; high risk behavior /lifestyle; homosexuals; human subject; intravenous drug abuse; male; methamphetamine; social support network; therapy design /development

DESCRIPTION (provided by applicant): The goal of this study is to develop and pilot test an innovative intervention "toolbox" to reduce HIV- associated sexual risk behaviors among methamphetamine using men who have sex with men (MUMSM). Our proposed study is based in San Diego, CA, the city with the third highest rates of methamphetamine use among arrestees in the country, and where methamphetamine accounts for over 50% of drug-related mentions in emergency departments. Drug users are a heterogeneous population requiring interventions tailored to meet their individual needs, yet most intervention trials have included only subsets of MUMSM. We propose to develop and pilot test an intervention that can be uniformly implemented among MUMSM who vary in terms of HIV serostatus and route of drug administration. Our specific aims are to: 1) develop a six-session intervention of theoretically-driven behavior change activities designed to decrease HIV- associated sexual risk behaviors among HIV-positive and HIV-negative, injection drug using (IDU) and non- IDU MUMSM; 2) determine the acceptability of the intervention series among MUMSM in all HIV and IDU strata; 3) determine the potential efficacy of the intervention series to decrease sexual risk behaviors; and 4) determine the cost-effectiveness of the intervention using a hypothetical range of effect sizes. To achieve these aims, focus groups and intervention pre-testing with the target population will be conducted to develop and refine the intervention. Eighty MUMSM will be enrolled in a single arm pilot study in which behavior change will be compared within participants on data collected using audio computer assisted self interviewing (ACASI) conducted at baseline and two months post-intervention. Our recruitment strategy will capitalize upon the ethnically diverse population of Hispanics and African American MUMSM in San Diego, as well as our ability to recruit MUMSM who are recent HIV seroconverters from an ongoing study of acute and early HIV infection. To our knowledge, this will be the first sexual risk reduction intervention ever studied that addresses the heterogeneous nature of MUMSM. If this pilot study shows promising results, it will provide the foundation for proposing a Phase III efficacy trial. If proven cost-effective, this intervention could fill a critical gap by providing much needed options for reducing the risk of sexual HIV transmission among MSM who use methamphetamine.

描述（由申请人提供）：本研究的目的是开发和试点测试创新的干预“工具箱”，以减少使用与男性发生性关系的男性（MUMSM）的甲基苯丙胺中与HIV相关的性风险行为。我们拟议的研究总部位于加利福尼亚州圣地亚哥，该城市在该国被捕者中使用甲基苯丙胺的率第三高，甲基苯丙胺占急诊室毒品相关提及的50％以上。吸毒者是一个异质的人群，需要为满足其个人需求而量身定制干预措施，但大多数干预试验仅包括MUMSM的子集。我们建议开发和进行试验测试一种干预措施，该干预措施可以在HIV血清和药物管理途径方面在MUMSM中统一实施。我们的具体目的是：1）对理论驱动的行为变化活动进行六阶段干预措施，旨在减少HIV阳性和HIV阴性，使用（IDU）和非IDU MUMSM的HIV阳性和HIV阴性的性风险行为； 2）确定在所有艾滋病毒和IDU地层中穆斯米的干预系列的可接受性； 3）确定干预系列的潜在功效以减少性风险行为； 4）使用假设的效应范围确定干预措施的成本效益。为了实现这些目标，将进行焦点小组和与目标人群进行预测试以开发和完善干预措施。八十MMSM将参加一项单臂试点研究，在该研究中，使用音频计算机辅助自我访谈（ACASI）（ACASI）在基线和干预后两个月进行的数据收集的数据中进行了更改。我们的招聘策略将利用圣地亚哥的西班牙裔和非裔美国人妈妈的种族多样化的人群，以及我们从正在进行的急性和早期艾滋病毒感染的研究中招募最近成为HIV Seroconverters的能力。据我们所知，这将是有史以来第一次研究穆姆斯的异质性质的性风险干预措施。如果该试点研究显示出令人鼓舞的结果，它将为提出III期疗效试验提供基础。如果证明具有成本效益，这种干预措施可以通过提供急需的选择来减少使用甲基苯丙胺的MSM性HIV传播的风险，来填补关键的空白。