Administrative supplement to afferent neurocardiac signals, cue reactivity, and cognitive control

对传入神经心脏信号、提示反应性和认知控制的行政补充

• 批准号: 10793875
• 负责人: Brandon L Alderman
• 金额: $ 2.21万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-05 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10793875
• 关键词: Administrative Supplement; Alcohol consumption; Arousal; Attention; Behavior Control; Behavioral; Brain; Breathing; Cognitive; Communities; Conscious; Data; Deposition; Environment; Event-Related Potentials; Heavy Drinking; Interruption; Measures; National Institute on Alcohol Abuse and Alcoholism; Physiological; Process; Public Health; Relapse; Signal Transduction; Structure; Techniques; Time; Training; alcohol cue; cognitive control; cognitive enhancement; craving; cue reactivity; data archive; data harmonization; data resource; neuroregulation; parent project; preservation; response

Abstract This is an application for an Administrative Supplement to an existing R21, NIAAA R21 AA029604 titled “Afferent neurocardiac signals, cue reactivity, and cognitive control”. Conscious attempts to regulate alcohol use can be undermined by alcohol cues in the environment that elicit automatic attention and physiological arousal processes that interrupt behavioral control. We previously discovered that a behavioral form of neuromodulation, termed ‘resonance paced breathing,’ can alter brain activation during passive viewing of alcohol cues. The current study measures brain response during active cognitive processing in the context of alcohol cues and examines whether this form of neuromodulation can be used to reduce cue reactivity and enhance cognitive control in real time. This Administrative Supplement request is to support our ability to harmonize data from R21 AA029604 to a common definition, including the creation of new event-related potential (ERP) data structures, and deposit them in the National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAADA). Our ability to devote the needed time and effort to fulfill this requirement for the parent project will preserve this unique and valuable data resource for the scientific community. The public health significance of an accessible, brief, and easily trained neuromodulation technique to reduce alcohol cue salience is great, as cue reactivity and craving are key precipitants of excessive drinking and relapse.

抽象的 这是对现有 R21、NIAAA R21 AA029604 的行政补充申请，标题为 “传入神经心脏信号、提示反应和认知控制”。 环境中的酒精暗示可能会破坏使用，从而引起自动注意和生理反应 我们之前发现，中断行为控制的唤醒过程。 神经调节，称为“共振节奏呼吸”，可以改变被动观看时的大脑激活 当前的研究测量了在主动认知处理过程中的大脑反应。 酒精提示并检查这种形式的神经调节是否可用于减少提示反应性 该行政补充请求旨在支持我们的能力：实时增强认知控制。 将 R21 AA029604 中的数据协调为通用定义，包括创建与事件相关的新数据 潜在的（ERP）数据结构，并将其存放在国家酒精滥用和酒精中毒研究所 数据存档 (NIAADA)。我们有能力投入所需的时间和精力来满足这一要求。 父项目将为科学界保留这一独特且有价值的数据资源。 一种易于使用、简短且易于训练的神经调节技术来减少酒精暗示的健康意义 显着性很大，因为提示反应和渴望是过量饮酒和复发的关键诱因。