Biocontainment Research Support Service(s) Core

生物防护研究支持服务核心

• 批准号: 10793952
• 负责人: Dominique M. Missiakas
• 金额: $ 78.33万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793952
• 关键词: Animal Model; Antibiotic Resistance; Articulation; Bacillus anthracis; Biochemical; Biological Assay; Biological Products; Cells; Charge; Chicago; Collaborations; Communities; Consultations; Containment; Data; Development; Diagnostic; Drug Screening; Emergency response; Emerging Communicable Diseases; Ensure; Environment; Equipment; Event; Genetic; Goals; Growth; Guidelines; Health; Immune response; Immunization; In Vitro; Infection; Infectious Diseases Research; Infrastructure; Institution; Instruction; Knowledge; Laboratories; Lead; Learning; Measures; Microbe; Mission; Mycobacterium tuberculosis; Names; Phenotype; Process; Protocols documentation; RNA Viruses; Reporting; Research; Research Personnel; Research Support; Research Training; Resistance profile; Rickettsia; Secure; Services; Sister; Specimen; Standardization; Supervision; Technology; Testing; Therapeutic; Training; Universities; Yersinia pestis; biocontainment facility; biodefense; biosecurity; design; experience; high risk; high throughput screening; in vivo; instrument; microbial; new pandemic; pathogen; recruit; response; skills; small molecule inhibitor; vaccine development; web page; web portal

PROJECT ABSTRACT (Core 3/C3ResearchSupport@HTRL) The Howard T. Ricketts Laboratory (HTRL) takes pride in its mission to provide a safe and secure environment for cutting-edge Biodefense and Emerging Infectious Diseases research, under the support and supervision of professionals with over 20 years of experience and under the umbrella of Core 3 (C3ResearchSupport@HTRL). The three aims of C3ResearchSupport@HTRL are to: (1) offer professional research services for the isolation and characterization of a wide range of RG3/Select Agent pathogens (sub- core C3Microbiology@HTRL); (2) offer professional research services in animal modelling of infection (sub- core C3AnimalModels@HTRLB); (3) offer hands-on A/BSL3 training to Core 3 Users (sub-core C3Training@HTRL). All these services will be advertised on the HTRL web page and will be rendered following free consultation. C3ResearchSupport@HTRL draws on the extensive expertise of Drs. Ahmed and Khader (Mycobacterium tuberculosis), Glenn Randall (RNA viruses) and Dominique Missiakas (Bacillus anthracis, Yersinia pestis, Rickettsia sp.) at the University of Chicago. C3ResearchSupport@HTRL will operate in collaboration with the RBL network, drawing on the expertise of 11 sister laboratories to provide broad research support, implement contingency plans, and ensure a prompt response in the event of imminent health threats to the nation. Briefly, C3Microbiology@HTRL will provide high-end technologies and expertise toward the isolation and characterization of RG3 pathogens (biochemical, genetic, phenotypic characterizations including antibiotic resistance profiles), the standardization of growth assays to test small molecule inhibitors, the study of pathogen interactions with host cells. C3AnimalModels@HTRL will provide standardized, high quality small animal models of infection for the development of countermeasures and for the study of host responses. C3Training@HTRL will offer Users of Core 3 an opportunity to receive basic instructions on biosafety, biosecurity, regulatory processes for the handling of high-risk pathogens, SOPs, and safe laboratory practice in BSL3. C3ResearchSupport@HTRL aims to provide pristine expertise to support research in response to new pandemics or biodefense threats on our nation or world-wide.

项目摘要（核心 3/C3ResearchSupport@HTRL） Howard T. Ricketts 实验室 (HTRL) 为其提供安全可靠的环境的使命感到自豪 在生物防御和新发传染病研究的支持和监督下 拥有 20 多年经验并在 Core 3 范围内的专业人士 (C3ResearchSupport@HTRL)。 C3ResearchSupport@HTRL 的三个目标是： (1) 提供专业的 为各种 RG3/Select Agent 病原体（亚种）的分离和表征提供研究服务 核心 C3Microbiology@HTRL); （2）提供感染动物模型专业研究服务（分 核心 C3AnimalModels@HTRLB); (3) 为核心 3 用户（子核心）提供 A/BSL3 实践培训 C3Training@HTRL）。所有这些服务将在HTRL网页上进行广告并提供 免费咨询后。 C3ResearchSupport@HTRL 借鉴了 Drs. 的广泛专业知识。艾哈迈德和 Khader（结核分枝杆菌）、Glenn Randall（RNA 病毒）和 Dominique Missiakas（芽孢杆菌） 芝加哥大学的炭疽菌、鼠疫耶尔森菌、立克次体）。 C3ResearchSupport@HTRL 将 与 RBL 网络合作运作，利用 11 个姊妹实验室的专业知识，提供 广泛的研究支持，实施应急计划，并确保在紧急情况下迅速做出反应 对国家健康的威胁。简而言之，C3Microbiology@HTRL 将提供高端技术和专业知识 RG3 病原体的分离和表征（生化、遗传、表型） 特征，包括抗生素耐药性概况），生长测定的标准化以测试小 分子抑制剂，研究病原体与宿主细胞的相互作用。 C3AnimalModels@HTRL 将提供 标准化、高质量的小动物感染模型，用于制定对策和 宿主反应的研究。 C3Training@HTRL 将为 Core 3 的用户提供获得基本知识的机会 有关生物安全、生物保安、处理高风险病原体的监管流程、SOP 和 BSL3 中的安全实验室实践。 C3ResearchSupport@HTRL 旨在提供原始专业知识来支持 针对我们国家或全世界的新流行病或生物防御威胁的研究。