MESA TASK AREA A - CORE STUDY OPERATIONS FIELD CENTER (FC).

MESA 任务区 A - 核心研究操作现场中心 (FC)。

• 批准号: 10788180
• 负责人: ALAIN BERTONI
• 金额: $ 50.99万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-19 至 2023-12-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788180
• 关键词: Address; African American; Age; Aging; Air Pollution; Ancillary Study; Ankle; Aorta; Area; Atherosclerosis; Behavioral; Biological; Brain; Cardiovascular Diseases; Cause of Death; Characteristics; Chinese; Clinical; Collaborations; Collection; Communities; Contracts; Coronary Arteriosclerosis; Correlation Studies; Data; Diabetes Mellitus; Disease; Disease Marker; Disease Outcome; Disease Progression; Dyslipidemias; Ethnic Origin; Event; Extramural Activities; Fostering; Functional disorder; Funding; Genetic; Goals; Heart; Heart failure; Hispanic; Hypertension; Incidence; Investigation; Kidney; Laboratories; Lung; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Multi-Ethnic Study of Atherosclerosis; Myocardial; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Organ; Paper; Participant; Persons; Photography; Policies; Population; Population Heterogeneity; Prevalence; Process; Publishing; Race; Research Personnel; Retina; Risk Factors; Risk Marker; Sampling; Smoking; Socioeconomic Factors; Subgroup; United States; United States National Institutes of Health; Vascular Diseases; Woman; Writing; X-Ray Computed Tomography; abdominal aorta; aged; brachial artery; cardiac magnetic resonance imaging; cardiovascular disorder risk; clinical examination; cohort; disease disparity; follow-up; genetic variant; heart function; improved; indexing; insight; interest; men; mortality; operation; population based; predict clinical outcome; psychologic; radial artery; recruit; response; sex; socioeconomics; tonometry; trend; ultrasound; vascular bed

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92018R0078, Multi-Ethnic Study of Atherosclerosis – Field Center) that seeks to continue the follow-up and examination of the MESA participants in an effort to address the following scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. In addition, the following operational goals will be addressed: 1) continue cohort follow-up and information collection to document clinical events; 2) continue to foster scientific collaborations; and 3) conduct a limited clinical examination of the MESA participants as a platform for ancillary study examination components. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.

动脉粥样硬化多种族研究 (MESA) 是一项针对动脉粥样硬化的相关性、预测因素和进展的研究 45-84 岁男性和女性不同人群样本中的亚临床心血管疾病 (CVD) 在 MESA 的初始资助期间，有 6,814 名参与者在基线时没有临床心血管疾病的证据。 2000 年至 2002 年期间从六个现场中心招募并检查亚临床冠心病的证据 动脉粥样硬化，使用计算机断层扫描、心脏 MRI、颈动脉超声、血流介导的肱动脉 扩张、桡动脉张力测量、踝臂指数测量和视网膜摄影。 其他变量包括腹主动脉 CT、颈动脉 MRI、心脏 MRI 标记，用于测量区域性 心肌功能；已建立的和假定的实验室风险标志物； 行为和环境特征；并在 MESA 子集中评估遗传变异 在随后的五次检查中重复了选定的组成部分的检查。 大约 16 年以来，该队列一直被持续跟踪临床 CVD 事件 基线检查。 本提案是为了响应 NHLBI RFP（编号 75N92018R0078，多民族研究 动脉粥样硬化 – 现场中心）寻求继续对 MESA 参与者进行随访和检查 努力实现以下科学目标：1）增强统计能力以进行分析 2）研究亚临床到的进展 临床心血管疾病；3) 识别新的危险因素或影响疾病的因素之间的相互作用 此外，还将解决以下操作目标：1）继续队列随访。 收集信息以记录临床事件；2) 继续促进科学合作；3) 对 MESA 参与者进行有限的临床检查，作为辅助研究检查的平台 成分。 该研究将继续支持 NHLBI 合同之外资助的深入辅助研究。 这些研究将在操作上整合到主要研究中，数据将在整个研究中心共享 根据当前的 MESA 和 NIH 数据共享政策，“MESA 套件”研究的数据将提供给。 感兴趣的调查人员通过明确的流程鼓励最大限度地利用数据，同时保护 参与者保密。