Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native People

美洲印第安人/阿拉斯加原住民药物代谢的药物基因组学方法

基本信息

批准号：
10790627
负责人：
Katrina G Claw
金额：
$ 29.53万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10790627
关键词：
Address African American African American population Alaska Native American Indians Assessment tool Award Bioethical Issues Bioethics Biomedical Research Colorado Communities Consent Data Electronic Mail Equity Ethics Focus Groups Foundations Future Genomics Goals Hispanic Hispanic Populations Hour Individual Infrastructure Knowledge Latino Latino Population Medical Methods Modeling Native-Born Ownership Parents Participant Pharmacogenomics Policies Population Population Heterogeneity Privacy Recontacts Recurrence Research Site Stigmatization Surveys Underrepresented Populations Universities Work biobank community based participatory research community involvement data sharing drug metabolism evidence base genomic data member parent grant participant enrollment patient engagement patient population personalized medicine pharmacogenetic testing recruit research study urban Native American

项目摘要

Project Summary/Abstract With the establishment of many large biobanks and consortia, and calls for increasing the diversity in participants, it is imperative to develop robust evidence-based approaches to support the engagement of diverse participants and to develop a proper bioethics-informed framework. The parent grant, entitled “Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native (AIAN) People”, strives to increase diversity in genomics research by developing a general model for research that engages all communities. In this supplement, we enhance the ability to achieve this goal by recruiting members of historically underrepresented communities to share perspectives on important bioethical issues related to participant engagement, return of results, and data sharing. We will identify these individuals by recontacting participants enrolled in the Colorado Center for Personalized Medicine (CCPM) Biobank research study at the University of Colorado Anschutz Medical Campus, who have already consented to participate in genomics research. Using mixed-methods and community-based participatory research frameworks, we aim to: 1) Understand perspectives on participant engagement, return of results, and data sharing from historically underrepresented participants (e.g., AIAN, African American, and Hispanic/Latino) in the CCPM Biobank with focus groups and surveys; and 2) Develop a cross-site framework for assessing biobank participants perspectives and engagement related to bioethical issues in biomedical research. The inclusion of African American and Hispanic/Latino participants, in addition to AIAN communities, aligns with the parent grant goal to equitably engage and build capacity for diverse communities. The CCPM Biobank offers an ideal population for these activities, given its diverse and growing population, unique infrastructure that allows for quick participant recontact, and successful reengagement with participants for research in recent years. Ultimately, these evidence-building efforts are essential for the broader scientific community to develop culturally informed, bioethical policies and frameworks around participant engagement, return of genomics research results, and data sharing.

项目摘要/摘要随着建立许多大型生物库和财团，并呼吁增加多样性参与者，必须开发强大的循证方法来支持参与潜水员参与者并开发适当的生物伦理知识框架。父母赠款，有权 “美洲印第安人/阿拉斯加本地人（Aian）人的药物代谢的药物基因组学方法”努力通过开发一种吸引所有人的研究的通用模型来增加基因组学研究的多样性社区。在这种补充中，我们通过招募成员来增强实现这一目标的能力历史上代表性不足的社区无法就与参与者参与，结果返回和数据共享。我们将通过重新连接来识别这些人参加者参加了科罗拉多州个性化医学中心（CCPM）生物银行研究研究科罗拉多大学Anschutz大学医学校园，他们已经同意参加基因组学研究。使用混合方法和基于社区的参与研究框架，我们的目标是：1）了解参与者参与，结果返回和数据共享的观点 CCPM生物库中代表性不足的参与者（例如Aian，非裔美国人和西班牙裔/拉丁裔）与焦点小组和调查； 2）开发一个用于评估生物库参与者的跨站点框架与生物医学研究中的生物伦理问题有关的观点和参与。包括非洲美国和西班牙裔/拉丁裔参与者，除了AIAN社区，还与父母赠款目标保持一致同样吸引并为潜水员社区增强能力。 CCPM生物库提供理想的人口对于这些活动，鉴于其潜水员和人口不断增长，独特的基础设施可以快速近年来，特定的重新连接，并成功地与参与者进行研究。最终，这些证据建设的努力对于更广泛的科学界在文化上发展至关重要围绕参与参与，基因组学研究回报的知情，生物伦理政策和框架结果和数据共享。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications.

DOI：
10.1093/gbe/evad222
发表时间：
2023-12-01
期刊：
GENOME BIOLOGY AND EVOLUTION
影响因子：
3.3
作者：
Wroblewski, Tadeusz H.;Witt, Kelsey E.;Lee, Seung-been;Malhi, Ripan S.;Peede, David;Huerta-Sanchez, Emilia;Villanea, Fernando A.;Claw, Katrina G.
通讯作者：
Claw, Katrina G.

Genetic research with Indigenous Peoples: perspectives on governance and oversight in the US.