CEIRR: COVID-19 Research Activities

CEIRR：COVID-19 研究活动

• 批准号: 10788049
• 负责人: Andrew S. Pekosz
• 金额: $ 40.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788049
• 关键词: 2019-nCoV; Animals; COVID-19; Cohort Studies; Coronavirus; Disease Outcome; Environmental Risk Factor; Evolution; Human; Immune; Immune response; Immunologic Factors; Infection; Molecular; Pathogenicity; Research; Research Activity; Sampling; Vaccination; Virus; cross immunity; improved; respiratory virus; response; transmission process

CEIRR will determine the molecular, ecologic and/or environmental factors that influence the evolution, emergence, transmission and pathogenicity of respiratory viruses, including coronaviruses such as SARS-CoV-2, and characterize the immune response to infection to improve understanding of the immune correlates of protection and cross-protection. CEIRR will carry out a host of activities, including cohort studies and human and animal sampling to further understanding of infection, transmission and vaccination; identification of immunological factors that determine disease outcome in the response to infection and vaccination; and studies to determine how viruses evolve, adapt and transmit between humans and at interspecies interfaces.

CEIRR将确定影响呼吸道病毒的进化，出现，传播和致病性的分子，生态和/或环境因素，包括冠状病毒（例如SARS-COV-2），并表征了对感染的免疫反应，以提高对保护和交叉进化的免疫相关性的了解。 CEIRR将开展许多活动，包括队列研究以及人类和动物采样，以进一步了解感染，传播和疫苗接种；鉴定在对感染和疫苗接种反应中决定疾病结果的免疫学因素；和研究以确定病毒如何在人类和种间界面之间发展，适应和传播。