Biostatistics Core - RC1

生物统计学核心 - RC1

• 批准号: 10728746
• 负责人: Qian-Li Xue
• 金额: $ 23.85万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728746
• 关键词: Address; Aging; American; Area; Basic Science; Biological; Biostatistics Core; Capital; Clinical; Collaborations; Collection; Communities; Complex; Computer Hardware; Computer software; Data; Data Analyses; Data Analytics; Databases; Dedications; Development; Disparity; Documentation; Effectiveness; Elderly; Engineering; Ensure; Etiology; Funding; Genomics; Gerontology; Goals; Health; Health Promotion; Housing; Informatics; Infrastructure; Institution; Intervention; Knowledge; Leadership; Life; Life Cycle Stages; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Modernization; Online Systems; Outcome; Pattern Recognition; Phenotype; Physiological; Population Attributable Risks; Populations at Risk; Prevention strategy; Property; Public Health Practice; Registries; Reproducibility of Results; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Role; Scholarship; Science; Scientist; Secure; Signal Transduction; Site; Specificity; Statistical Data Interpretation; Syndrome; System; Technology; Technology Assessment; Training; Translating; Translational Research; Translations; Work; career; clinical practice; clinical translation; cohort; data complexity; data infrastructure; data management; design; education research; empowerment; endophenotype; experience; faculty mentor; faculty support; frailty; high dimensionality; innovation; middle age; molecular marker; new technology; next generation; pilot test; prevent; sound; statistics; success; synergism; tool; translational study; web site

RC1 – Biostatistics Core: Project Summary Since mid-2003, this OAIC Biostatistics Core (RC1) has dedicated critically needed resources toward the quantitative challenges of research on frailty. Partnering in OAIC leadership, and working closely with other OAIC resource cores, it has helped develop the careers of an interdisciplinary cohort of junior faculty supported by the Research Education Component (REC)—and beyond—and ensured expert design and analysis of pilot, external, and de novo studies needed to advance science on frailty. It now proposes to continue in these efforts, by providing: (1) mentorship for junior faculty supported by our REC, and our broader OAIC, in developing careers focused on frailty and aging; (2) new data and computing infrastructure and software, including web-based data housing and acquisition tools; (3) expertise for science on frailty, through support for the design, statistical analysis, and data management of research projects, and through making available new data analytic methodologies that are essential to studying the complex syndrome of frailty; and (4) leadership and visibility for frailty-related scientific and health promotion endeavors at Johns Hopkins, throughout the OAIC network, and in the broader gerontological community. Our support and leadership in these areas have been significant and wide-reaching, and could not be provided without the resources of this Core. The leadership is experienced, expert, deeply immersed in scholarship on aging, and visible in both gerontology and statistics. The Core will continue to support every REC and pilot-supported investigator as per their need. The Core synergizes actively with other OAIC resource cores, as evidenced by progress over the last cycle. Our team includes a statistical genomics expert to enhance our collaborations with the Biological Mechanisms Core (RC2). We also have engaged an internal consultant with expertise in signal intensive measurement to enhance our interactions with our new Technological Assessment and Solutions Core (RC4). We will continue to provide design and analytic expertise and support a Registry collaboratively with the Clinical Translation Core (RC3). Regarding new methodologies: research will develop approaches needed to better (i) assess prefrailty, hence identify at-risk persons early enough to intervene successfully; (ii) delineate heterogeneous etiology underlying frailty; (iii) design studies to assess frailty intervention; (iv) characterize attributable fraction of frailty risk factors over the lifecourse, and (v) address frailty disparities. By efforts along all these lines, this Core will contribute crucially to the success of this OAIC in answering a next generation of questions on frailty, and achieving findings' translation toward increased independence of older persons.

RC1 - 生物统计学核心：项目摘要 自2003年中期以来，这种OAIC生物统计学核心（RC1）一直致力于迫切需要资源 关于脆弱的研究的定量挑战。在OAIC领导层合作，并与其他 OAIC资源核心，它帮助发展了跨学科队列的职业生涯 在研究教育部分（REC）的支持下，并确保了专家设计和 对飞行员，外部和从头研究的分析需要提高科学的脆弱性。现在提出 继续进行这些努力，通过提供：（1）我们的rec支持的初级教师和我们 更广泛的OAIC，在发展从事脆弱和衰老的职业发展； （2）新数据和计算基础架构 和软件，包括基于Web的数据壳和采集工具； （3）脆弱科学专业知识， 通过支持设计项目的设计，统计分析和数据管理，并通过 提供新的数据分析方法，这些方法对于研究的复杂综合征至关重要 脆弱； （4）约翰斯的领导力和可见性科学和健康促进努力 霍普金斯，整个OAIC网络以及更广泛的老年学界。我们的支持和 在这些领域的领导力是重要的，而且范围很广，没有 该核心的资源。领导层是经验丰富的，专家，深深地沉浸在老龄化的奖学金中， 在老年病和统计学中可见。核心将继续支持每个Rec和Pilot支持 调查员根据他们的需求。核心与其他OAIC资源核心积极协同作用，如 在最后一个周期中的进展。我们的团队包括统计基因组学经验，以增强我们的合作 具有生物学机制核心（RC2）。我们还与内部顾问订婚了专业知识 信号密集度量的测量，以增强我们与新技术评估的相互作用 解决方案核心（RC4）。我们将继续提供设计和分析专业知识并支持注册表 与临床翻译核心（RC3）合作。关于新方法：研究将发展 需要更好的方法（i）预处理，因此很早就确定危险的人以进行干预 成功地; （ii）描述了脆弱的基础异质病因； （iii）评估脆弱的设计研究 干涉; （iv）表征了生命力中脆弱的风险因素的可归因于属性的部分，并且（v）地址 脆弱的分布。通过所有这些努力，这个核心将完全有助于这种OAIC的成功 在回答有关脆弱的下一代问题时，并实现了发现的转化 老年人的独立性。