14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center

14/14 APOL1长期肾移植结果网络（APOLLO）科学数据研究中心

基本信息

批准号：
10728589
负责人：
DONALD W BOWDEN
金额：
$ 90.1万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10728589
关键词：
APOL1 gene Acute Adult African American African American population African ancestry Allografting American Ancillary Study Apolipoproteins Archives Bioinformatics Biometry Childhood Chronic Kidney Failure Clinical Clinical Data Cohort Studies Collection Communities Creatinine DNA Data Data Analyses Databases Decision Making Development Disparity Eligibility Determination Engraftment Enrollment Ensure Ethicists Ethics Ethnic Population European Evaluation Failure Genes Genetic Genotype Glomerular Filtration Rate Graft Survival Health Health Care Costs Health protection Histology Human Resources Individual Informed Consent Institutional Review Boards Kidney Kidney Transplantation Laboratories Leadership Link Manuals Monitor Multicenter Studies National Institute of Diabetes and Digestive and Kidney Diseases Nephrology Observational Study Operative Surgical Procedures Organ Organ Procurements Outcome Outcome Assessment Participant Patients Physicians Population Predisposition Procedures Process Prospective Studies Proteinuria Protocols documentation Publications Quality of life Renal function Reporting Research Research Personnel Resources Retrospective Studies Risk Safety Sampling Serum Sickle Hemoglobin Statistical Data Interpretation Structure Time Transplant Recipients Transplantation United Network for Organ Sharing United States National Institutes of Health Universities Variant Virus Diseases Vital Status Work biobank clinical center data quality design donor-specific antibody ethnic disparity forest genetic information genome-wide graft function improved kidney allograft living kidney donor medical schools organ allocation organ procurement transplantation network post-transplant precision medicine primary outcome programs prospective racial population recruit repository response risk variant skills tool web site working group

项目摘要

The NIH APOL1 Long-term Transplantation Outcomes Network (APOLLO) Collaborative U01 is performing a national prospective evaluation of donor and recipient apolipoprotein L1 gene (APOL1) risk variants in US kidney transplants from African American donors to determine their effect on transplant outcomes. In addition, post- donation health and kidney function of African American living kidney donors will be assessed. We are applying to continue serving as the APOLLO Scientific and Data Research Center (SDRC). Shorter renal allograft survival is observed for transplantations from deceased African American kidney donors, relative to deceased European American kidney donors. Reasons for this are unknown, but retrospective reports suggest that presence of two APOL1 risk variants in kidney donors may contribute to the disparity. These variants are common in populations with recent African ancestry (such as African Americans), where they are strongly associated with chronic kidney disease, but rare in other racial/ethnic groups. APOL1 genotype data may provide more accurate assessment of the likelihood for long-term renal allograft function in donor kidneys, thereby improving matching of donor kidneys with potential recipients in order to optimize renal allograft and patient survival. This information may better inform physicians about organ quality prior to making decisions on allocation. It may also inform the safety of living kidney donation. Before APOL1 genotypes can be used clinically, the prospective national APOLLO study was required to evaluate kidney transplant outcomes from African American donors and recipients of their kidneys based on APOL1. APOLLO collects information lacking from retrospective studies, including recipient APOL1 genotypes, renal histology in engrafted kidneys and presence or development of BK viral infections, donor specific antibodies, and acute rejections after kidney transplantation. We apply to continue to perform these activities for the APOLLO Network: overall study coordination, assist with ensuring compliance with the Protocol and Manual of Procedures, maintain data tracking tools and the study website, collect and archive clinical and outcomes data, perform genotyping, statistical analyses, assessment of outcomes including the primary outcome “time to allograft failure in transplanted kidneys from African American donors based on donor APOL1 genotypes”, and complete the bio-repository. We will longitudinally assess vital status, kidney function and proteinuria in living African American kidney donors based on APOL1 genotypes and prospectively assess effects of donor APOL1 genotypes on serum creatinine concentration, estimated glomerular filtration rate, and proteinuria in kidney transplant recipients with functioning grafts. APOLLO results have the potential to transform the organ allocation and informed consent processes in kidney transplantation, optimize renal allograft survival, reduce discard of good-quality kidneys, and protect the health of living kidney donors.

NIH APOL1长期移植结果网络（Apollo）协作U01正在执行美国肾脏中供体和接受者载脂蛋白L1基因（APOL1）风险变体的国家预期评估从非裔美国人的捐助者中移植以确定其对移植结果的影响。此外，将评估非裔美国人活肾供体的捐赠健康和肾脏功能。我们正在申请继续担任阿波罗科学和数据研究中心（SDRC）。较短的肾脏同种异移植生存相对于已故的欧洲人，观察到已故的非裔美国肾脏捐赠者的移植美国肾脏捐赠者。原因是未知的，但是回顾性报告表明两个存在肾脏供体中的APOL1风险变异可能会导致差异。这些变体在人群中很常见与最近的非洲血统（例如非裔美国人），他们与慢性肾脏密切相关疾病，但在其他种族/族裔群体中很少见。 APOL1基因型数据可能会提供更准确的评估供体肾脏中长期肾脏同种异体功能的可能性，从而改善供体的匹配肾脏具有潜在的接受者，以优化同种异体移植和患者生存。此信息可能在做出分配决策之前，更好地将医生告知医生有关器官质量。它也可能告知安全活肾捐赠。在临床上使用APOL1基因型之前，前瞻性国家阿波罗需要研究来评估非裔美国人捐助者的肾脏移植结果和接受者的接受者基于apol1的肾脏。阿波罗收集了回顾性研究缺乏的信息，包括收件人 APOL1基因型，植入肾脏中的肾脏组织学以及BK病毒感染的存在或发展，供体特异性抗体和肾移植后的急性拒绝。我们申请继续执行这些针对阿波罗网络的活动：整体研究协调，协助确保遵守协议和程序手册，维护数据跟踪工具和研究网站，收集和存档临床和结果数据，进行基因分型，统计分析，评估结果包括主要结果“从非裔美国人捐助者的移植儿童中出现同种异体移植失败的时间 APOL1基因型”，并完成生物依赖性。我们将纵向评估重要状态，肾功能和基于APOL1基因型的非裔美国肾脏供体的蛋白尿和前瞻性评估供体APOL1基因型对血清肌氨酸浓度，估计肾小球滤过率和具有功能移植物的肾脏移植受者中的蛋白尿症。阿波罗的结果有可能转化肾移植中的器官分配和知情同意过程，优化同种异体移植的存活，减少丢弃优质孩子的遗漏，并保护活着的孩子们的捐助者的健康。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

APOL1 genotyping in kidney transplantation: to do or not to do, that is the question? (pro).

DOI：
10.1016/j.kint.2020.11.025
发表时间：
2021-07
期刊：
Kidney international
影响因子：
19.6
作者：
Freedman BI;Poggio ED
通讯作者：
Poggio ED

Recipient APOL1 Genotype Effects on Outcomes After Kidney Transplantation.

受者 APOL1 基因型对肾移植后结果的影响。

DOI：
10.1053/j.ajkd.2021.11.001
发表时间：
2022
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
0
作者：
Freedman,BarryI;Mena-Gutierrez,AlejandraM;Ma,Lijun
通讯作者：
Ma,Lijun

Improving Kidney Disease Research in the Black Community: The Essential Role of Black Voices in the APOLLO Study.