Vestibular Precision: Physiology and Pathophysiology

前庭精确度：生理学和病理生理学

基本信息

批准号：
10728408
负责人：
Faisal Karmali
金额：
$ 8.43万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10728408
关键词：
Ablation Acoustic Neuroma Affect Age Attention Bayesian Modeling Bayesian Prediction Behavior Behavioral Biological Assay Brain Characteristics Clinical Compensation Cues Data Dizziness Ear Environment Excision Exposure to Eye Movements Fatigue Fiber Functional disorder Goals Head Learning Lesion Measurement Measures Mediating Methods Modality Morbidity - disease rate Motion Motor Motor Pathways Nerve Noise Operative Surgical Procedures Outcome Outcome Measure Pathologic Pathway interactions Patient Education Patients Perception Peripheral Physiology Play Population Postoperative Period Predictive Value Process Research Residual state Role Rotation Sensory Signal Transduction Source Stimulus Symptoms System Testing Theoretical model Time Training Translations Validation Variant Vestibular Nerve Visual Work behavioral response disability experience human subject improved nerve damage neural novel oculomotor otoconia predict clinical outcome response secondary outcome sensor symptomatology tumor vestibulo-ocular reflex

项目摘要

The goal of this proposal is to investigate vestibular precision by quantifying the variability in behavioral responses that result from the neural noise inherent to the peripheral and central vestibular systems. Because neural noise contaminates the signals that are transduced by the ear and processed by the brain, vestibular- mediated behavioral responses vary even when identical stimuli are provided. In this proposal, we focus on vestibular precision in human subjects and investigate its sources, its effects on behavior, and its degradation when the periphery is damaged and its potential plasticity. Specifically, we will investigate: SA 1: Vestibular precision in normal subjects – physiology: A) We will measure the angular and linear vestibulo-ocular reflex (VOR) using novel motion combinations that reinforce or cancel eye movement responses, which will allow us to determine the distribution and magnitude of noise produced in the sensory (canal, otolith) pathways and in the oculomotor pathway. We hypothesize that normal subjects will demonstrate a bimodal distribution of noise with either sensory or motor predominance, and that subjects with more sensory noise will demonstrate other behavioral characteristics that reflect this characteristic (e.g., higher perceptual thresholds); and B) We will assay vestibular noise from trial-trial variations in the VOR and will compare VOR dynamics with those predicted by a Bayesian model using the assayed noise. We predict variations in VOR dynamics across subjects, age and stimulus amplitudes will be consistent with Bayesian processing of noise. Potential confounding factors will be carefully controlled, including attention, fatigue, and non-vestibular cues. SA 2: Vestibular precision after peripheral damage – pathophysiology: A) We will examine the changes in vestibular precision that occur when one vestibular nerve is damaged (by a vestibular schwannoma, VS) and after the damaged nerve is surgically sectioned, and will investigate if precision measurements can provide evidence of pathologic noise produced by the damaged nerve and therefore help predict clinical outcome when the nerve is sectioned. We hypothesize that changes in signal reliability due to the VS will be traceable to both the reduced redundancy caused by loss of afferent fibers and to aberrant noise generated by the damaged vestibular nerve and that changes in precision after neurectomy will correlate the outcome measures that characterize patient disability; and B) We will examine the plasticity of vestibular precision in the oculomotor and perceptual realms with the goal of determining if precision can be improved. Using novel training approaches that provide challenging signal extraction tasks, we hypothesize that subjects will improve their vestibular precision on the trained task. As secondary outcome measures, we will determine if training one behavior generalizes to the non-trained behavior and if patient’s symptoms are affected by improved precision.

该建议的目的是通过量化行为的变异性来研究前庭精度神经噪声引起的反应继承了外围和中央前庭系统。因为神经噪声污染了由耳朵翻译并由大脑处理的信号，前庭 - 即使提供相同的刺激，介导的行为反应也有所不同。在此提案中，我们专注于人类受试者的前庭精度并研究其来源，对行为的影响及其降解当周围损坏及其潜在的可塑性时。具体来说，我们将调查： SA 1：正常受试者的前庭精度 - 生理学：a）我们将测量角度和线性使用新颖的运动组合来增强或取消眼动，前庭 - 眼反射（VOR）响应，这将使我们能够确定感觉中产生的噪声的分布和大小（运河，耳石）途径和眼动途径。我们假设正常受试者将证明具有感觉或运动占主导地位的噪声的双峰分布，并且具有更多感觉的受试者噪声将展示其他反映这一特征的行为特征（例如，更高的感知阈值）; b）我们将在VOR中进行试验变化中的前庭噪声，并将比较VOR 动力学具有使用测定的噪声预测的贝叶斯模型预测的动力学。我们预测VOR的变化跨受试者，年龄和刺激放大器的动力学将与贝叶斯的噪声处理一致。潜在的混杂因素将受到仔细控制，包括注意力，疲劳和非vesibular提示。 SA 2：周围损伤后的前庭精度 - 病理生理学：a）我们将检查当一种前庭神经受损时（前庭造型瘤）和在通过手术切开损坏的神经后，将研究精确测量是否可以提供受损神经产生的病理噪声的证据，因此有助于预测临床结果神经分割。我们假设由于VS引起的信号可靠性的变化将可以追溯到两者由于损失的传入纤维的损失和受损的异常噪声而导致的冗余降低前庭神经以及神经术后精度的变化将使结果指标相关表征患者残疾； b）我们将检查动眼前庭精度的可塑性和感知领域的目标是确定是否可以提高精度。使用新颖的培训提供挑战信号提取任务的方法，我们假设受试者将改善他们的训练有素的任务上的前庭精度。作为次要结果措施，我们将确定是否训练一个行为推广到非训练的行为，如果患者的症状受到改善的精度影响。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Vestibular dysfunction in neurofibromatosis type 2-related schwannomatosis.

DOI：
10.1093/braincomms/fcad089
发表时间：
2023
期刊：
BRAIN COMMUNICATIONS
影响因子：
4.8
作者：
Madhani, Amsal S.;King, Susan;Zhu, Jennifer;Karmali, Faisal;Welling, D. Bradley;Cai, Wenli;Jordan, Justin T.;Lewis, Richard F.
通讯作者：
Lewis, Richard F.

Vestibular Precision at the Level of Perception, Eye Movements, Posture, and Neurons.