HIGHLY ATTENUATED SIV VIF DNA VACCINES

高度减毒 SIV VIF DNA 疫苗

• 批准号: 7562168
• 负责人: Ellen Elizabeth Sparger
• 金额: $ 18.16万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562168
• 关键词: Attenuated; Cells; Computer Retrieval of Information on Scientific Projects Database; Cytidine Deaminase; Funding; Grant; Institution; Proteins; Research; Research Personnel; Resources; Source; Subfamily lentivirinae; Tissues; United States National Institutes of Health; Vaccines; Viral; Virion; Virus; cellular targeting; vif Genes

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The accessory gene vif of lentiviruses is required for efficient viral replication. Vif inhibits virion incorporation of a cellular cytidine deaminase, APOBEC3G, by targeting this cellular protein for proteosomal degradation. A vif-deleted virus may be persistent in the host, although at extremely low levels and restricted to specific tissues or cell subsets with reduced expression of APOBEC3 proteins.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：慢病毒的辅助基因vif是病毒有效复制所必需的。 Vif 通过靶向细胞蛋白进行蛋白体降解来抑制病毒颗粒掺入细胞胞苷脱氨酶 APOBEC3G。 vif缺失的病毒可能会在宿主体内持续存在，尽管其水平极低，并且仅限于APOBEC3蛋白表达减少的特定组织或细胞亚群。