Center for Visual and Neurocognitive Rehabilitation

视觉和神经认知康复中心

• 批准号: 10782409
• 负责人: A. M. Barrett
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10782409
• 关键词: Acceleration; Age related macular degeneration; Aging; Alzheimer' s Disease; Animal Experiments; Animal Model; Biomedical Engineering; Brain Diseases; Caring; Collaborations; Communities; Disease; Doctor of Philosophy; Education; Ensure; Extramural Activities; Fostering; Funding; Goals; Grant; Health; Human; Intervention; Joints; Literature; Mentorship; Mission; Molecular Biology; Neurocognitive; Neurocognitive Deficit; Neurology; Ophthalmology; Patients; Personal Satisfaction; Physical Exercise; Physical Medicine; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Retina; Retinal Degeneration; Scientist; Services; Sleep; Stroke; System; Technology; Testing; Time; Training; Universities; Veterans; Visual; Visual impairment; career development; clinical trials in animals; design; experience; healthy aging; imaging facilities; meetings; military veteran; neural repair; neuroimaging; outreach; preclinical study; prevent; programs; psychoeducation; psychoeducational; recruit; rehabilitation research; repetitive transcranial magnetic stimulation; research and development; research study; synergism; telerehabilitation

The mission of the Atlanta VAMC Rehabilitation Research and Development Center for Visual and Neurocognitive Rehabilitation (CVNR) is to foster the best possible health and well-being of Veterans through uniquely synergistic research studies targeting disorders impacting visual and/or neurocognitive function. Our Center's organization is designed to catalyze synergies amongst collaborating CVNR researchers and with scientist and clinician affiliates to maximize and accelerate tangible benefits for Veterans' health. The Internal Steering Group is the hub of CVNR operational decisions and comprises Krish Sathian, MD, PhD (Executive Director); Bruce Crosson, PhD (Executive Associate Director); Machelle Pardue, PhD (Associate Director for Scientific Projects); Steven Wolf, PT, PhD (Associate Director for Training), Patricia Griffiths, PhD (Assistant Director for Outreach); Keith McGregor, PhD (Career Development Awardees' Representative); and Lisa Calas (Administrative Officer). The CVNR has three Research Programs: (A) Retinal & Neural Repair, (B) Visual Rehabilitation, and (C) Neurocognitive Rehabilitation. The CVNR's emphasis is on highly collaborative research efforts that straddle and integrate across the Programs. To this end, we plan three Integrative Projects that each draw on expertise and ideas from multiple Programs: (1) Physical exercise to prevent progression of age-related macular degeneration in Veterans; (2) Repetitive transcranial magnetic stimulation in aging and stroke: mechanistic pre-clinical studies using animal models; and (3) Making a psycho-educational tele- rehabilitative sleep intervention accessible for Veterans with visual impairment and their cohabitating care- partners. Each of these projects will be funded by the CVNR for an initial 2-year period, with the goal of seeding extramurally funded research by that time. In subsequent years, additional Integrative Projects will be funded after competitive review. Note that the activity of CVNR investigators is not limited to these Integrative Projects; each investigator is involved in multiple other projects that will be further enriched by the experiences and results of the Integrative Projects. The CVNR will also fund a set of Cores to provide services to investigators. Three of these are ongoing: a Neuroimaging Core directed by Dr. Crosson, a Molecular Biology Core directed by Dr. Boatright, and an Administrative Core directed by Ms. Calas. Two additional Cores will be added in year 3 of the new grant cycle: a Physical Exercise Core directed by Dr. Nocera and a Tele-rehabilitation Core co-directed by Drs. Griffiths and McGregor and Mr. Ross. The CVNR has strong ties with local affiliates, including the Birmingham-Atlanta GRECC; Emory University, particularly its imaging centers, its Alzheimer's Disease Research Center, and its Departments of Neurology, Ophthalmology and Rehabilitation Medicine; Georgia Institute of Technology; the joint Biomedical Engineering Department of Emory and Georgia Tech; and Georgia State University. Our research findings will be shared through the national network of Centers, disseminated in the scientific literature and at scientific meetings, presented to VA and other clinicians locally and nationally, and distilled into educational programs for Veterans, other consumer groups, and the community. The CVNR is committed to capacity building by recruiting trainees as well as junior and senior investigators into the VA system and providing trainees with outstanding mentorship to ensure the continued vitality of rehabilitation research.

亚特兰大 VAMC 视觉和康复研究与开发中心的使命 神经认知康复 (CVNR) 旨在促进退伍军人的最佳健康和福祉 通过针对影响视觉和/或神经认知的疾病的独特协同研究 功能。我们中心的组织旨在促进 CVNR 合作之间的协同作用 研究人员以及科学家和临床医生附属机构，以最大限度地提高和加速为患者带来的切实利益 退伍军人的健康。内部指导小组是 CVNR 运营决策的中心，包括 Krish Sathian，医学博士、哲学博士（执行董事）；布鲁斯·克罗森博士（执行副主任）；马歇尔 Pardue 博士（科学项目副主任）； Steven Wolf，PT，博士（副主任 培训），Patricia Griffiths 博士（外展助理主任）；基思·麦格雷戈博士（职业 发展获奖者代表）；和丽莎·卡拉斯（行政官员）。 CVNR 拥有三个研究项目：(A) 视网膜和神经修复、(B) 视觉康复、 (C) 神经认知康复。 CVNR 的重点是高度协作的研究工作 跨计划并整合。为此，我们计划了三个综合项目，每个项目都包含 来自多个项目的专业知识和想法：（1）体育锻炼以预防与年龄相关的疾病进展 退伍军人黄斑变性； (2)重复经颅磁刺激在衰老和中风中的作用： 使用动物模型进行机械临床前研究； (3) 制作心理教育电视节目 视力障碍退伍军人及其同居护理人员可以获得康复睡眠干预 合作伙伴。这些项目中的每一个都将由 CVNR 资助，为期两年，目标是 那时就开始了校外资助的研究。在随后的几年中，更多的综合项目将 竞争性审查后获得资助。请注意，CVNR 研究人员的活动不仅限于这些 综合项目；每个研究者都参与多个其他项目，这些项目将进一步丰富 综合项目的经验和成果。 CVNR 还将资助一组核心，为调查人员提供服务。其中三个是 正在进行中：由 Crosson 博士指导的神经影像核心，由 Boatright 博士指导的分子生物学核心， 以及由 Calas 女士领导的行政核心。新版本的第 3 年将添加两个额外的核心 资助周期：诺塞拉博士指导的体育锻炼核心和共同指导的远程康复核心 博士。格里菲斯、麦格雷戈和罗斯先生。 CVNR 与当地附属机构有着密切的联系，其中包括 伯明翰-亚特兰大 GRECC；埃默里大学，特别是其成像中心，其阿尔茨海默病 研究中心及其神经内科、眼科、康复医学科；乔治亚州 技术学院；埃默里大学和佐治亚理工学院联合生物医学工程系；和 佐治亚州立大学。 我们的研究成果将通过全国中心网络共享，并在 科学文献和科学会议上，向 VA 和当地和全国的其他临床医生展示， 并提炼成针对退伍军人、其他消费者群体和社区的教育计划。这 CVNR 致力于通过招募实习生以及初级和高级研究人员来进行能力建设 融入VA系统，为学员提供出色的指导，确保VA的持续活力 康复研究。

项目成果

Effects of Combined Aerobic Exercise and Cognitive Training on Verbal Fluency in Older Adults.

有氧运动和认知训练相结合对老年人言语流畅性的影响。

• 发表时间: 2020
• 作者: Nocera, Joe R;Mammino, Kevin;Kommula, Yash;Wharton, Whitney;Crosson, Bruce;McGregor, Keith M
• 通讯作者: McGregor, Keith M

Spatial neglect treatment: The brain's spatial-motor Aiming systems.

空间忽视治疗：大脑的空间运动瞄准系统。

• 发表时间: 2022-06
• 影响因子: 2.7
• 作者: Barrett, A M;Goedert, Kelly M;Carter, Alexandre R;Chaudhari, Amit
• 通讯作者: Chaudhari, Amit

Spatial Neglect and Anosognosia After Right Brain Stroke.

右脑中风后的空间忽视和失认症。

• 发表时间: 2021-12-01
• 作者: Barrett; A M
• 通讯作者: A M

Repetitive Anodal Transcranial Direct Current Stimulation Hastens Isoflurane-Induced Emergence and Recovery and Enhances Memory in Healthy Rats.

重复阳极经颅直流电刺激可加速异氟烷诱导的苏醒和恢复，并增强健康大鼠的记忆力。

• 发表时间: 2021
• 影响因子: 5.7
• 作者: Mansouri, Mohammad Taghi;García, Paul S
• 通讯作者: García, Paul S

Feasibility of Auricular Field Stimulation in Fibromyalgia: Evaluation by Functional Magnetic Resonance Imaging, Randomized Trial.

耳廓场刺激治疗纤维肌痛的可行性：功能磁共振成像评估，随机试验。

• 发表时间: 2021-03-18
• 作者: Woodbury, Anna;Krishnamurthy, Venkatagiri;Gebre, Melat;Napadow, Vitaly;Bicknese, Corinne;Liu, Mofei;Lukemire, Joshua;Kalangara, Jerry;Cui, Xiangqin;Guo, Ying;Sniecinski, Roman;Crosson, Bruce
• 通讯作者: Crosson, Bruce